The Senior Medical Director Clinical Development will lead the clinical team for a high-visibility program and report to the Global Clinical Head. This is an excellent opportunity for an experienced and motivated drug developer to advance an innovative, late-stage study.

The SD will provide medical leadership across late stage. Acting as a key medical expert on the study team(s), the SD may also serve as medical monitor as needed.

In this role, the SD will work cross-functionally and mentor Physicians, Clinical Directors, and Clinical Development Scientists. The position may include direct and indirect managerial responsibilities for team members across the Clinical Development organization. The SD will also contribute to the development of regulatory, therapeutic area, and functional strategies.

This position offers the opportunity to collaborate closely with enterprise-level, cross-functional teams, including AstraZeneca Business Units, CVRM, and strategic development partners. The ideal candidate will thrive in a fast-paced, proactive, and collaborative culture-demonstrating strong communication skills, scientific leadership, and the ability to drive impact across both internal and external teams.

You will be responsible for:

• Lead cross-functional clinical program teams to deliver high-quality studies and research strategies, ensuring scientific rigor and optimal benefit-risk management.

• Serve as the clinical authority for assigned programs, overseeing study design, execution, data interpretation, and regulatory deliverables in compliance with GCP.

• Provide strategic medical and scientific input across R&D, translational science, commercial, and business development activities, including due diligence and collaborations.

• Mentor and develop Medical Directors, Clinical Development Scientists, and fellows to build organizational scientific and leadership capability.

• Represent the program internally and externally through governance presentations, regulatory interactions, scientific publications, and engagement with key opinion leaders.

You will need to have:

• MD with specialty training in Internal Medicine.

• 7+ years of experience in clinical development; clinical research, global regulatory, and product development expertise

• Has prepared documents and attended regulatory meetings with FDA and other regulatory agencies.

• Experience designing and executing multinational clinical trials required

• Demonstrated ability to lead cross-functional teams to define clinical strategy and clinical study design.

• Experience supporting business development activities.

• Ability to learn rapidly, think critically, and operate effectively in a fast-paced environment.

• The duties of this role are generally conducted in an office environment. As is typical of an office-based role, employees must be able, with or without an accommodation to: use a computer; engage in communications via phone, video, and electronic messaging; engage in problem solving and non-linear thought, analysis, and dialogue; collaborate with others; maintain general availability during standard business hours.

We would prefer for you to have:

• Board Certification.

• Experience in ATTR amyloidosis

• Preferred: Advanced knowledge of the assigned therapy area is desired, with the capability to interpret, discuss and represent trial or program level data.

• PhD in related discipline desirable.

• Experience with BLA/MAA submissions.

• Demonstrated experience as a clinical trialist with a strong external network, including relationships with key investigators, sites, and patient partners.

• Experience operating at the clinical-commercial interface and shaping clinical strategies with commercial insight.

• Broad awareness of the global therapeutic landscape and regulatory environment within rare or cardiometabolic diseases.

• Willingness and ability to travel nationally and internationally.

In-Office Hybrid

This role has an expectation of working in the office a minimum of 3 days a week. When we put unexpected teams in the same room, we unleash bold thinking with the power to inspire life-changing medicines. Inperson working give us the platform we need to connect, work at pace and challenge perceptions. That's why we work, on average, a minimum of three days per week from the office. But that doesn't mean we're not flexible. We balance the expectation of being in the office while respecting individual flexibility. Join us in our unique and ambitious world.

The annual base pay for this position ranges from 280,895.20 to 421,342.80 USD Annual . Our positions offer eligibility for various incentives-an opportunity to receive short-term incentive bonuses, equity-based awards for salaried roles and commissions for sales roles. Benefits offered include qualified retirement programs, paid time off (i.e., vacation, holiday, and leaves), as well as health, dental, and vision coverage in accordance with the terms of the applicable plans.

Date Posted
30-Jul-2026

Closing Date
12-Aug-2026