Natera

Senior Director, ECD Product Strategy & Lifecycle

Natera$192K — $280K *
US-AnywhereRemote in United States
Pharmaceuticals & Biotech
8 - 10 years of experience
Job Overview by Ladders

Qualifications

  • Bachelor's degree required; advanced degree (PhD, MD, or MBA) strongly preferred.
  • 10+ years in product management or related roles within diagnostics, biotechnology, medical devices, or health technology.
  • Experience with early cancer detection products is strongly preferred.
  • Proven track record managing products across the full lifecycle, particularly successful launches.
  • Demonstrated leadership experience in hiring, coaching, and developing product managers.
  • Familiarity with developing regulated clinical products and collaborating on clinical trials and regulatory pathways.

Responsibilities

  • Own product vision, strategy, and roadmap for ECD portfolio in alignment with corporate goals.
  • Lead multi-year strategic planning for ECD products, focusing on investment and resource allocation.
  • Identify new market opportunities through comprehensive analyses and insights.
  • Define value propositions and differentiation strategies based on competitive intelligence and customer needs.
  • Manage the entire product lifecycle from concept to sunset, ensuring timely launches and optimization.
  • Conduct customer research with clinicians, health systems, and payers to inform product decisions.
  • Build robust business cases, evaluating financial forecasts and ROI for products.

Benefits

  • Work from either the San Carlos, CA office or remotely within the USA.
  • Opportunity to lead and develop a high-performing product management team.
  • Engagement with cross-functional teams including R&D, clinical, and regulatory.
  • Be at the forefront of innovative early cancer detection solutions.
Full Job Description
POSITION SUMMARY:

As a market leader in cfDNA-based diagnostics, we are expanding our Early Cancer Detection (ECD) portfolio to deliver transformative clinical impact at scale. The SeniorDirector, ECD Product Strategy & Lifecycle will lead the strategy, development, and lifecycle management of a portfolio of ECD products, from concept through launch, growth, and optimization.

This role is accountable for defining product vision and strategy, translating unmet clinical and customer needs into differentiated products, and driving execution through strong cross-functional leadership. The Senior Director will build and manage a high-performing product management team and partner closely with R&D, clinical, regulatory, commercial, medical affairs, and operations to ensure successful delivery of business and patient outcomes.

POSITION LOCATION:

This position can be out of our San Carlos, CA office or Remote, USA.

PRIMARY RESPONSIBILITIES:

Product Strategy & Portfolio Leadership
  • Own the product vision, strategy, and roadmap for the Early Cancer Detection portfolio, aligned with corporate strategy and long-term growth objectives
  • Lead annual and multi-year strategic planning for ECD products, including investment prioritization, sequencing, and resource allocation
  • Identify, size, and segment new market opportunities using top-down and bottom-up analyses, incorporating clinical, commercial, and customer insights
  • Define clear value propositions and differentiation strategies based on competitive intelligence, customer needs, and evolving standards of care

Product Lifecycle Management
  • Lead products across the full lifecycle, from concept and feasibility through development, launch, post-launch optimization, and eventual sunset
  • Drive definition of product requirements, success metrics, and launch readiness in partnership with cross-functional teams
  • Guide trade-off decisions across performance, features, timelines, and investment, particularly in technically complex genomic and algorithm-driven products

Customer & Market Insights
  • Lead qualitative and quantitative customer research with clinicians, health systems, payers, partners, and internal stakeholders
  • Translate insights into clear product requirements, roadmap decisions, and business cases
  • Monitor competitive landscape, emerging technologies, and regulatory or reimbursement changes impacting early cancer detection

Financial & Business Planning
  • Build and oversee robust business cases, including revenue forecasts, unit economics, ROI, and NPV analyses for new and existing products
  • Pressure-test assumptions, evaluate sensitivities, and make data-driven investment recommendations
  • Partner with finance and commercial leadership to align product strategy with financial objectives

People & Cross-Functional Leadership
  • Lead, and develop a team of Product Managers supporting innovation and lifecycle initiatives within Early Cancer Detection
  • Establish and scale product management best practices, processes, and metrics
  • Act as a senior product leader and influencer across R&D, clinical, regulatory, medical affairs, commercial, and executive leadership
  • Clearly communicate product vision, strategy, and priorities to align stakeholders and inspire teams

QUALIFICATIONS:
  • Bachelor's degree required; advanced degree (PhD, MD, or MBA) strongly preferred
  • 10+ years of experience in product management, product strategy, consulting, or related roles within diagnostics, biotechnology, medical devices, or health technology
  • Prior experience with early cancer detection products strongly preferred
  • Demonstrated experience managing products across the full lifecycle, including successful product launches
  • Proven people leadership experience, including hiring, coaching, and developing product managers
  • Experience developing regulated clinical products and working closely with clinical trials and regulatory pathways

KNOWLEDGE, SKILLS, AND ABILITIES:
  • Strategic, analytical thinker with the ability to translate complex data into clear product and business decisions
  • Strong market research capabilities, including customer interviews and quantitative analysis
  • Comfortable diving deep into technical, algorithmic, and molecular concepts and translating them into customer-facing product features
  • Hands-on financial modeling and business case development expertise
  • Exceptional cross-functional leadership, communication, and influence skills
  • Entrepreneurial mindset with a bias toward action, accountability, and results


The pay range is listed and actual compensation packages are based on a wide array of factors unique to each candidate, including but not limited to skill set, years & depth of experience, certifications and specific office location. This may differ in other locations due to cost of labor considerations.

Remote USA

$192,600-$280,000 USD

About Natera

Natera is a biotechnology company that focuses on genetic testing and diagnostics. The company's products are designed to help diagnose and treat genetic diseases, cancer, and other conditions. Natera's pipeline includes products for reproductive health, oncology, and organ transplantation. The company was founded in 2003 and is headquartered in San Carlos, California.
Learn more about Natera
Size
2,670 employees
Market Cap
$4.5 billion
Industry
Net Income
-$229.7 million
Founded
2004
5 Year Trend
+24.1%
Revenue
$391 million
NASDAQ

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