What You'll Do- Lead medicinal chemistry design and synthesis across small-molecule, peptide, and peptide-adjacent programs, from target compound selection through synthesis, purification, characterization, and handoff for biological testing.
- Design and execute synthetic routes using solid-phase and solution-phase workflows, including functional group transformations, coupling chemistry, protecting group strategies, late-stage diversification, cleavage/deprotection where relevant, purification, and analytical characterization.
- Learn, operate, and help maintain key chemistry instrumentation, including HPLC/prep HPLC, LC-MS, microwave-assisted synthesis systems, and related analytical or purification platforms.
- Troubleshoot synthetic and analytical issues, including failed reactions, low conversion, poor selectivity, low crude purity, side products, solubility limitations, purification challenges, and instrument downtime.
- Interpret SAR, in vitro, and in vivo data to design next-round compounds, using potency, selectivity, stability, exposure, tolerability, and efficacy data to guide priorities.
Who You Are- You have 5+ years of hands-on industry experience in medicinal or synthetic organic chemistry. Peptide experience is helpful, but not required.
- You have strong experimental judgment, deep troubleshooting ability, and a high bar for execution.
- You are comfortable owning chemistry end to end: compound design, route selection, synthesis, purification, characterization, QC, and preparation for biological testing.
- You work well close to the biological readout and use potency, efficacy, stability, exposure, and tolerability data to sharpen the next design cycle.
- You are proactive and reliable when issues arise. When a synthesis fails, an instrument is down, purity is low, or a handoff needs clarification, you help diagnose the issue, communicate clearly, and work toward a practical resolution.
Pay & Benefits- In addition to the posted salary range, we offer generous equity options.
- Compensation will depend on the skills, experience, and scope of impact you bring. If your background, experience, or compensation needs fall outside this range, we are still open to a conversation based on the scope and impact you could bring.
- $500+ monthly wellness budget for training, supplements, coaching, recovery, or other tools that help you perform at your best.
- Healthcare: We offer a broad range of medical, dental, and vision coverage options, with Capable covering 100% of the base policy.
- You will also have access to HSA, FSA, and 401K plans.
- Healthy dinners with the team are provided daily.
- We support visa sponsorship where appropriate, including O-1, H-1B, J-1, TN, and other employment-based pathways. Our team is already international, with members from Canada, Pakistan, Germany, Austria, Switzerland, China, India, and the United States.
Application ProcessOur process is fast, transparent, and personal. We care about getting to know the person behind the application.
- Initial application
- First phone screen
- Second phone screen
- In-person work trial in San Francisco: designed to give both sides a realistic sense of working together. Get to know the founding team!
Apply TodayCurious but not sure? Apply anyway. It takes 5 minutes, and you do not need to be actively job searching to start a conversation.
Some of the best people do not map perfectly to a job description. If this sounds like a place where you could do important work, we would like to hear from you.
And if someone exceptional comes to mind, send them our way here. We read every referral carefully, and if your referral joins Capable, we'll send you a thank-you bonus.
