Scientist - Screening & Analytical Chemistry - Waltham, MA, Full-time
We are seeking a Scientist in Screening & Analytical Chemistry to lead development of high-throughput analytical workflows. This role focuses on method development for rapid, targeted metabolite quantification and integration with screening pipelines.
This hands-on position requires a desire and ability to work as an integral part of a multidisciplinary team, as well as the demonstration of a high degree of flexibility, creativity, and initiative. This person will be expected to play an integral part of Manus's research and development team located in Waltham, MA.
Responsibilities- Develop and optimize analytical methods for targeted metabolite quantification
- Lead method development on GC/MS, GC-FID, and LC-QQQ-MS platforms
- Design high-throughput analytical workflows with fast cycle times
- Develop sample preparation and derivatization strategies
- Work with automation and screening teams to support microtiter plate-based fermentations
- Analyze and interpret large datasets
- Mentor junior staff
- Interface with instrument vendors to maintain uptime and optimal performance
- Author SOPs and technical reports
Basic Qualifications- PhD in Analytical Chemistry, Chemistry, or related field OR
- MS with 8+ years or BS with 13+ years relevant experience
- Strong experience in analytical method development
Required Technical Expertise- GC-FID and GC/MS assay development for targeted quantitation and metabolite profiling
- LC/QQQ-MS assay develop for targeted quantitation
- Assay optimization for speed, sensitivity, and throughput
Preferred Experience- Experience with high-throughput screening environments
- Integration of analytical workflows with automation
- Familiarity with liquid handling platforms
- Experience with LIMS (e.g. Benchling) and large datasets
- Industrial biotech or applied R&D experience
- Experience with the following types of analytical instrumentation
- UHPLC
- GC-FID
- GC/MS
- LC/QQQ-MS
- Experience with a variety of sample extraction and preparation techniques, applying automated solutions when appropriate, from complex matrices
- Microbial fermentation broth
- Microbial biomass
- Purified extracts
