We are seeking a highly motivated, hands-on Scientist, Bioscience, to support later-stage radio conjugate programs through assay development, pre-clinical profiling of mechanisms-of-action, and in vitro drug-drug combination studies. This role is ideal for a strong laboratory scientist who thrives in a fast-paced research environment and enjoys working across disciplines to generate high-quality data that advances discovery and development programs. The successful candidate will contribute to the design, execution, analysis, and reporting of a broad range of cellular, molecular, and histological assays. Working closely with cross-functional colleagues in biology, in vivo pharmacology and radiochemistry, this individual will provide cross-program support to advance targeted radio therapy development. Accountabilities

• Independently executes routine in vitro drug mechanism-of-action and cell viability experiments by applying techniques of cell and molecular biology (e.g. cell culture, flow cytometry, immunoblotting, immunofluorescence). Contributes to cell line model development (lentiviral transduction, CRISPR/Cas9), and mammalian tissue processing or analysis (e.g. immunohistochemistry, immunoblotting, RNA/DNA sequencing sample preparation).

• Communicates the results to team members and is involved in the interpretation of data.
  
• Supports a team and works collaboratively with project managers to ensure the efficient relay of information and forward translation of data.
  
• Maintains a well-developed understanding of approaches to radio conjugate mechanism-of-action and development and applies a broader functional knowledge of the procedures used by diverse project groups to support the department where needed.
  
• Assesses and reports data in a clear and concise manner, with a clear understanding of its implications within the overall context of drug discovery.
  
• Provides technical instruction to the team and allocates administrative work where possible.
  
• Shares relevant external published papers with peers.
  
• Communicates and shares information between distinct projects within the bioscience function and across other functions.
  
• Ensures own work, and work of peers, is compliant with Good Laboratory Practice, Safety, Health and Environment standards and all other relevant internal AstraZeneca standards and external regulations.

Essential Skills and Experience

• MSc. with at least 2 years or B.Sc. with at least 5 years of post-graduate academic or industry experience in Molecular/Cell Biology, Immunology, Biochemistry, or related disciplines.
• Demonstrated experience with biochemical and cell biology methods such as cell culture, CRISPR/Cas9, immunohistochemistry, flow cytometry, and Western blotting.
• Experience developing, optimizing, and executing cell-based assays.
• Excellent organizational skills and demonstrated record keeping abilities
• Demonstrated safe handling of chemical and biohazardous materials.
• Ability to adapt to, perform, and develop unfamiliar methods in a rapidly evolving research environment.

Desirable Skills/Experience

• Experience in handling radioisotopes is considered an asset.

Annual base salary for this position ranges from 82,377.60 to 108,120.60.

AstraZeneca is committed to providing fair and equitable compensation opportunities to all colleagues. Our compensation policies and practices have been designed to allow colleagues to progress through the salary range over time as they progress in their role. The range provided in this posting represents an offer pay range used in a majority of situations. The base pay offered will vary depending on multiple individualized factors, including the candidate's skills and experience, job-related knowledge, and other specific business and organizational needs. In some cases, offers outside the range may also be considered to address unique circumstances.

In addition, our permanent positions offer an annual Variable Pay Bonus/Short Term Incentive opportunity as well as eligibility to participate in our equity-based long-term incentive program (if applicable to role).  Benefits offered for permanent roles include a competitive Flex Benefits & Retirement Savings Program, 4 weeks’ paid vacation, and annual Personal Days. Fixed Term Contract/Temporary positions (excluding students) are offered a Contract Benefits Program.

We are using AI as part of the recruitment process.

This advertisement relates to a current vacancy.