Job DescriptionThe Pharmacokinetics, Dynamics, Metabolism and Bioanalytics (PDMB) group is seeking a dynamic, strategic thinking and collaborative Scientist to contribute to our company drug discovery and early clinical development efforts, with a focus on lab-based bioanalytical efforts for small molecules and peptides. This position will be based at our research labs in Boston, MA. Experience utilizing liquid-chromatography / mass spectrometry platforms to quantify small molecules and/or peptides from various in vitro and in vivo matrices is required. The ability to develop new bioanalytical methods, efficiently utilize data processing platforms and perform basic instrument maintenance is a plus. The position will allow for regular interaction with multi-disciplinary discovery project teams and subject matter experts from other functions within our Research & Development Division. The ideal candidate will possess the ability to innovate, independently execute and be fully accountable for their scientific deliverables. The candidate will have the opportunity to present their work at departmental meetings as well as promote our company science through publications and external presentations.
In this exciting position, your primary roles will include:- Utilize state-of-the-art liquid chromatography/mass spectrometry approaches to quantitate drug levels in various in vitro and in vivo matrices in support of PK and PK/PD efforts.
- Analyze, review and utilize quantitative data to estimate pharmacokinetic parameters in support of multiple programs across various therapeutic areas.
- Close collaboration with PDMB subject-matter experts in Boston (MA), South San Francisco (CA) and West Point (PA) aimed at efficiently supporting a dynamic and fast-paced research portfolio.
Education Minimum Requirement- Bachelor's degree in biochemistry, chemistry, pharmacology, pharmaceutical sciences, biology, chemical engineering, biomedical engineering or related STEM field with 3+ years relevant postgrad laboratory experience or MS degree and 0+ years of experience.
Required Experience and Skills- Demonstrated experience utilizing liquid-chromatography / mass spectrometry (LC/MS) platforms to quantify small molecules and/or peptides from various in vitro and in vivo matrices
- Working knowledge of traditional bioanalytical instrumentation and techniques (primarily LC/MS), including method development, optimization and general maintenance
- Experience preparing samples from various in vitro and in vivo matrices for bioanalytical characterization including, but not limited to, protein precipitation, liquid/liquid extraction and solid-phase extraction techniques.
- Strong interpersonal, communication, problem solving and collaborative qualities to deliver high-quality results in a fast-paced environment
Preferred Experience and Skills- Ability to design, interpret and troubleshoot experiments aimed at addressing complex questions.
- Familiarity with electronic laboratory notebooks, Watson LIMS and related record-keeping approaches.
- Experience working within a research-driven pharmaceutical company.
#EligibleforERP
Required Skills: Bioanalysis, Biochemistry, Data Analysis, Data Visualization, Detail-Oriented, Drug Metabolism, Ethical Compliance, Good Laboratory Practices (GLPs), Liquid Chromatography-Mass Spectrometry (LC-MS), Pharmaceutical Sciences, Pharmacodynamics, Pharmacokinetics, Pharmacology, Pharmacotherapeutics, Sample Preparations, Small Molecules
Preferred Skills: Current Employees apply HERE
Current Contingent Workers apply HERE
US and Puerto Rico Residents Only:Our company is committed to inclusion, ensuring that candidates can engage in a hiring process that exhibits their true capabilities. Please click here if you need an accommodation during the application or hiring process.
The salary range for this role is
$98,000.00 - $154,300.00
This is the lowest to highest salary we in good faith believe we would pay for this role at the time of this posting. An employee's position within the salary range will be based on several factors including, but not limited to relevant education, qualifications, certifications, experience, skills, geographic location, government requirements, and business or organizational needs.
The successful candidate will be eligible for annual bonus and long-term incentive, if applicable.
We offer a comprehensive package of benefits. Available benefits include medical, dental, vision healthcare and other insurance benefits (for employee and family), retirement benefits, including 401(k), paid holidays, vacation, and compassionate and sick days. More information about benefits is available at https://jobs.merck.com/us/en/compensation-and-benefits.
You can apply for this role through https://jobs.merck.com/us/en (or via the Workday Jobs Hub if you are a current employee). The application deadline for this position is stated on this posting.
San Francisco Residents Only: We will consider qualified applicants with arrest and conviction records for employment in compliance with the San Francisco Fair Chance Ordinance
Los Angeles Residents Only: We will consider for employment all qualified applicants, including those with criminal histories, in a manner consistent with the requirements of applicable state and local laws, including the City of Los Angeles' Fair Chance Initiative for Hiring Ordinance
Search Firm Representatives Please Read Carefully Merck & Co., Inc., Rahway, NJ, USA, also known as Merck Sharp & Dohme LLC, Rahway, NJ, USA, does not accept unsolicited assistance from search firms for employment opportunities. All CVs / resumes submitted by search firms to any employee at our company without a valid written search agreement in place for this position will be deemed the sole property of our company. No fee will be paid in the event a candidate is hired by our company as a result of an agency referral where no pre-existing agreement is in place. Where agency agreements are in place, introductions are position specific. Please, no phone calls or emails.
Employee Status: Regular
Relocation:Domestic
VISA Sponsorship:No
Travel Requirements:No Travel Required
Flexible Work Arrangements:Not Applicable
Shift:Not Indicated
Valid Driving License:No
Hazardous Material(s):Bloodborne pathogens, BSL2, OEB4
Job Posting End Date:08/7/2026
*A job posting is effective until 11:59:59PM on the day BEFORE the listed job posting end date. Please ensure you apply to a job posting no later than the day BEFORE the job posting end date. 
