Job DescriptionThe Drug Metabolism and Pharmacokinetics (DMPK) group within the PDMB function is seeking a highly motivated, collaborative scientist to support mass spectrometry-based immunogenicity assessment. The successful candidate will contribute to the execution of MHC-Associated Peptide Proteomics (MAPPs) studies and related LC-MS workflows used to characterize antigen presentation and support biologics, conjugates and peptides programs.
The ideal candidate will primarily perform laboratory-based activities and be responsible for executing cell-based and immunoaffinity workflows, preparing samples for LC-MS analysis, maintaining laboratory instrumentation, and generating high-quality experimental data. The candidate will work in a multidisciplinary environment alongside scientists in immunology, bioanalysis, and mass spectrometry and will have opportunities to present findings at departmental meetings and contribute to scientific publications and presentations.
In this exciting role, your primary activities will include:- Execute MAPPs (MHC-associated peptide proteomics) experiments to support immunogenicity risk assessment of therapeutic candidates.
- Maintain and expand human cell cultures, including routine cell maintenance, cell counting, viability assessment, and preparation of samples for downstream analysis.
- Perform immunoaffinity enrichment workflows, including antibody-based capture, antigen processing, and sample preparation for LC-MS analysis.
- Operate, maintain, and troubleshoot LC-MS instrumentation, including Orbitrap-based high-resolution mass spectrometry platforms .
- Generate, document, and review high-quality experimental data following established laboratory procedures and data integrity standards.
- Support optimization of sample preparation workflows and laboratory automation initiatives to improve efficiency and reproducibility.
- Maintain laboratory equipment, consumables, and records while ensuring compliance with safety and quality requirements.
QUALIFICATIONS:Education:- Bachelor's (with 3+ years) or Master's in Biochemistry, Analytical Chemistry, Immunology, Cell Biology, Molecular Biology, Pharmaceutical Sciences or a related scientific discipline with relevant laboratory experience
Required Experience and Skills:- Hands-on experience with fundamental laboratory techniques, including pipetting, sample preparation, buffer preparation, and laboratory documentation
- Understanding of immunoaffinity (IA) or antibody-based enrichment techniques
- Experience operating or supporting LC-MS workflows and bioanalytical instrumentation
- Experience maintaining mammalian cell cultures and performing routine cell-based laboratory procedures
- Familiarity with high-resolution mass spectrometry (e.g., Orbitrap) platforms and associated data acquisition software
- Ability to collect, document, and analyze experimental data
- Understanding of research principles and experimental methodology
- Demonstrated attention to detail, organization, and commitment to generating high-quality scientific data
Preferred Experience and Skills:- Knowledge of MAPPs (MHC-associated peptide proteomics) workflows and immunogenicity assessment strategies
- Familiarity with Thermo Scientific Orbitrap mass spectrometry platforms, including Eclipse Orbitrap systems
- Experience with proteomics sample preparation, peptide characterization, and mass spectrometry-based proteomics workflows
- Experience with automated liquid handling systems, robotics, or laboratory automation platforms
- Experience using proteomics data analysis software such as Proteome Discoverer, MaxQuant, Genedata Expressionist, Peaks, or related tools
- Experience working in a pharmaceutical, biotechnology, or research-driven environment
#EligibleforERP
Required Skills: Antibodies, Biochemistry, Cell Culture Techniques, Laboratory Documentation, Liquid Chromatography-Mass Spectrometry (LC-MS), Mammalian Cell Culture, Mass Spectrometry (MS), Pharmacokinetics, Pipetting, Sample Preparations
Preferred Skills: Current Employees apply HERE
Current Contingent Workers apply HERE
US and Puerto Rico Residents Only:Our company is committed to inclusion, ensuring that candidates can engage in a hiring process that exhibits their true capabilities. Please click here if you need an accommodation during the application or hiring process.
The salary range for this role is
$108,000.00 - $170,100.00
This is the lowest to highest salary we in good faith believe we would pay for this role at the time of this posting. An employee's position within the salary range will be based on several factors including, but not limited to relevant education, qualifications, certifications, experience, skills, geographic location, government requirements, and business or organizational needs.
The successful candidate will be eligible for annual bonus and long-term incentive, if applicable.
We offer a comprehensive package of benefits. Available benefits include medical, dental, vision healthcare and other insurance benefits (for employee and family), retirement benefits, including 401(k), paid holidays, vacation, and compassionate and sick days. More information about benefits is available at https://jobs.merck.com/us/en/compensation-and-benefits.
You can apply for this role through https://jobs.merck.com/us/en (or via the Workday Jobs Hub if you are a current employee). The application deadline for this position is stated on this posting.
San Francisco Residents Only: We will consider qualified applicants with arrest and conviction records for employment in compliance with the San Francisco Fair Chance Ordinance
Los Angeles Residents Only: We will consider for employment all qualified applicants, including those with criminal histories, in a manner consistent with the requirements of applicable state and local laws, including the City of Los Angeles' Fair Chance Initiative for Hiring Ordinance
Search Firm Representatives Please Read Carefully Merck & Co., Inc., Rahway, NJ, USA, also known as Merck Sharp & Dohme LLC, Rahway, NJ, USA, does not accept unsolicited assistance from search firms for employment opportunities. All CVs / resumes submitted by search firms to any employee at our company without a valid written search agreement in place for this position will be deemed the sole property of our company. No fee will be paid in the event a candidate is hired by our company as a result of an agency referral where no pre-existing agreement is in place. Where agency agreements are in place, introductions are position specific. Please, no phone calls or emails.
Employee Status: Regular
Relocation:Domestic
VISA Sponsorship:No
Travel Requirements:No Travel Required
Flexible Work Arrangements:Not Applicable
Shift:1st - Day
Valid Driving License:No
Hazardous Material(s):N/A
Job Posting End Date:08/27/2026
*A job posting is effective until 11:59:59PM on the day BEFORE the listed job posting end date. Please ensure you apply to a job posting no later than the day BEFORE the job posting end date. 
