Job Function: Discovery & Pre-Clinical/Clinical Development
Job Sub Function: Pharmacology
Job Category:Scientific/Technology
All Job Posting Locations:Spring House, Pennsylvania, United States of America
Job Description:About Innovative Medicine Our expertise in Innovative Medicine is informed and inspired by patients, whose insights fuel our science-based advancements. Visionaries like you work on teams that save lives by developing the medicines of tomorrow.
Join us in developing treatments, finding cures, and pioneering the path from lab to life while championing patients every step of the way.
Learn more at https://www.jnj.com/innovative-medicine
About Oncology Our expertise in Innovative Medicine is informed and inspired by patients, whose insights fuel our science-based advancements. Visionaries like you work on teams that save lives by developing the medicines of tomorrow.
Our Oncology team is focused on the elimination of cancer by discovering new pathways and modalities to finding treatments and cures. We lead where medicine is going and need innovators with an unwavering commitment to results.
Join us in developing treatments, finding cures, and pioneering the path from lab to life while championing patients every step of the way.
We are searching for the best talent for a Scientist, in Oncology Discovery In Vivo, Innovative Medicine, located in Spring House, PA.
Join our Oncology In Vivo team to support the characterization and preclinical development of small molecules, biologics, radioligands, antibody-drug conjugates, cell therapies, and immune modulators for cancer treatment. In this hands-on role you will assist with in vivo and ex vivo studies, collect and analyze data, and work closely with cross-functional research teams to contribute to the advancement of innovative therapies.
Key Responsibilities- Assist in the design, execution, and interpretation of in vivo pharmacology studies to validate and characterize oncology targets and therapeutic agents.
- Develop and optimize in vivo models, including efficacy, mechanism of action, PK/PD biomarker studies, and dose/schedule evaluations in diverse cancer models.
- Lead the development and adaptation of research methods from literature or internal innovation to improve existing models.
- Perform complex in vivo preclinical cancer studies, ensuring scientific rigor, compliance with all regulatory requirements, internal quality standards and timely delivery.
- Analyze and present data using appropriate statistical methods in formats suitable for internal stakeholders and external publications.
- Collaborate across functions and contribute to projects beyond your own area, acting as a scientific resource and thought leader.
- Manage multiple projects simultaneously, coordinating with project leaders and external partners as needed.
- Contribute to ex vivo analyses (flow cytometry, IHC, ELISA, RT-PCR, Luminex®) and imaging studies (bioluminescent imaging for metastatic disease models) as required.
- Stay current with oncology and tumor immunology literature to integrate emerging insights into research strategies.
- Communicate clearly and professionally, delivering impactful presentations and reports to internal teams and external audiences.
- Flexibility required for occasional weekend, evening and holiday dosing or animal monitoring. Some onboarding training may be conducted in Spring House, PA site.
Qualifications- Bachelor's degree (BS/ BA) in the life sciences (molecular/ cellular biology, biochemistry, pharmacology, tumor immunology) with at least 8 years of relevant pharmaceutical or biotech industry/ lab/ academic experience OR a Master's degree (MS) with at least 4 years of relevant experience, or PhD with 1-3 years of relevant post-graduate experience.
- Ability to cell culture of cancer and immune cells.
- Experience with oncology-relevant xenografts and syngeneic mouse models is required; primary grafts, orthotopic models, humanized models, or genetically engineered tumor models are preferred.
- Experience with small molecules and/ or biologics is required
- Experience with immune-modulatory agents, vaccines or cell therapies such as CAR-Ts is desirable.
- Strong skills in tumor implantation techniques and dosing, proper handling of therapeutics, tumor measurement, health monitoring, and data collection and analysis are required.
- Experience with bioluminescent imaging, flow cytometry, IHC, ELISA, RT-PCR, Westerns, or Luminex® is desirable.
- Strong organizational skills including the ability to manage several projects simultaneously; detail oriented with excellent record keeping skills are required.
- Excellent interpersonal skills with the ability to interact effectively with matrixed teams, internally and externally, is required.
- Excellent data management and record-keeping skills are required.
- Ability to effectively present scientific data and concepts to colleagues and teams is critical.
- Proven track record of adherence to animal welfare and compliance regulations is critical.
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Required Skills: Preferred Skills:Analytical Reasoning, Assay Development, Data Savvy, Data Science, Drug Discovery Development, Pharmaceutical Medicine, Pharmacodynamics, Pharmacokinetics, Pharmacology, Pharmacometrics, Presentation Design, Proactive Behavior, Process Oriented, Scientific Research, Technologically Savvy
