Scientist, In Vivo CAR-T Pipeline as part of the
Research and Development team based in
Philadelphia, PA.
Role OverviewLegend Biotech is a global leader in the development of innovative cell-based therapies. We are seeking a highly motivated Scientist to join our growing in vivo CAR-T development team. This role provides the opportunity to make a direct scientific impact by advancing our in vivo CAR-T platform from early discovery through preclinical development.
The successful candidate will bring deep technical expertise in cell&gene therapy, along with a strong foundation in immunology and virology. You will work in a highly collaborative environment alongside research and early development teams to translate novel scientific concepts into robust therapeutic candidates. This role requires scientific rigor, hands-on execution, intellectual curiosity, and the ability to thrive in a fast-paced research setting.
This is a fully onsite, lab-based position located in Philadelphia, PA.
Key Responsibilities- Design, plan, and execute experimental studies to advance cell and gene therapy platforms and pipeline programs.
- Conduct and analyze in vitro and in vivo studies to assess product potency, efficacy, and safety.
- Develop, optimize, and troubleshoot experimental assays, including:
- Cell line engineering
- Cell-based functional and cytotoxicity assays
- ELISA and PCR-based assays
- High-throughput binder screening
- Viral vector packaging and titration
- Analyze and interpret complex datasets and maintain accurate experimental documentation.
- Prepare clear, high-quality reports and presentations and communicate findings to internal research and cross-functional teams.
Requirements- PhD in Immunology, Cell Biology, Molecular
- OR Master's degree with 3-6+ years of relevant experience
- Hands-on experience in immunology, cell therapy, gene therapy, or related fields
- Experience with viral vector systems (especially lentivirus) is highly preferred
- Industry or postdoctoral experience is a plus
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Please note: These benefits are offered exclusively to permanent full-time employees. Contractors are not eligible for benefits through Legend Biotech. 
