AbbVie

Scientist I / II Biologics Production Outsourcing Specialist

AbbVie • $88K — $105K *
North Chicago, IL 60064In-Person
Pharmaceuticals & Biotech
Less than 5 years of experience
Today
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Job Overview by Ladders

Qualifications

  • BSc/MSc in biology, chemistry, or related field with relevant experience (5+ years BS, 2+ years MS for Scientist I; 7+ years BS, 5+ years MS for Scientist II).
  • Solid background in biologics production including plasmid design and protein expression in CHO cells.
  • Experience collaborating with CROs specifically for protein production activities.
  • Proficient in analytical QC for biologics including SEC and mass spectrometry.
  • Skilled in process development, optimization, and troubleshooting therapeutic protein issues.

Responsibilities

  • Execute and manage outsourcing of therapeutic biologics production at CROs.
  • Collaborate with vendors on protein production tasks including QC and method strategy.
  • Plan and strategize to ensure timely project execution and risk management.
  • Manage molecule registration in IT systems throughout the production process.
  • Enhance data sharing strategies to improve efficiency in tracking and reporting.
  • Perform necessary biophysical characterization and analytical QC beyond vendor services.
  • Align vendor QC methodologies with internal standards for consistency and quality assurance.

Benefits

  • Comprehensive benefits package including medical/dental/vision insurance.
  • Paid time off including vacation, holidays, and sick leave.
  • Eligibility for short-term incentive programs.
  • 401(k) plan for eligible employees.
Full Job Description
Job Description

Overview:

The Biotherapeutics Production group at AbbVie is seeking a research scientist to coordinate and manage biologics generation outsourcing at CROs. The group routinely outsources protein production for hundreds of biologics molecules per year at scales of 100 mg to 50 grams to generate therapeutic biologics in support of AbbVie's worldwide drug discovery efforts.

Key Responsibilities:
  • Execute and coordinate outsourcing of therapeutic biologic production at CROs at scales of 100 mg - 50 grams for all required purification requests (hundreds/year) in alignment with functional goals and group scientific objectives.
  • Collaborate with CRO vendors, and manage all aspects of protein production, including ordering, sequence design, expression method, scale selection, primary capture, secondary purification strategy, as well as all QC and analytical work.
  • Ensure successful and timely execution of outsourcing projects through sound planning and strategy design, as well as risk management.
  • Manage pre-registration and post-registration of generated molecules in appropriate IT systems.
  • Develop strategy for two-way data sharing and receipt with each vendor to allow seamless tracking of requests and import of data to LIMS system, as well as to increase efficiency and accuracy of data delivery.
  • Perform biophysical characterization and analytical QC (including SEC, intact and reduced mass spectrometry, endotoxin and HCP testing) for all proteins that require QC beyond what vendor offers.
  • Work with vendors to align their QC methodologies (SEC columns, buffers, MS reduction protocol, and HCP assay) with standard methods used in BDS-BP group, and advance collaboration with vendors to deliver equivalent QC data packages as those generated internally eliminating the need for internal QC of outsourced projects.
  • Interact with requestors and collaborators to keep them informed of the progress and status of their outsourced projects.
  • Communicate results and unexpected observations in timely manner to management and appropriate audience.
  • Resolve unexpected scientific problems that arise by utilizing novel approaches and collaborative partnership with internal and external colleagues and vendors.
  • Work independently on the design, execution, and interpretation of experimental results.
  • Analyze, document, and report data concisely and rigorously.


Qualifications

Qualifications:

Position will be hired based on level of experience and education.

Scientist I Qualifications:
  • Bachelors or Masters in biology, chemistry, biochemistry or related field with typically 5+ (BS) or 2+ (MS) years of experience.
  • Prior experience with all aspects of biologics production, including expression plasmid design, stable and transient protein expression in CHO cells, primary protein capture methods using Protein A, CH1, kappa select, and secondary purification strategies using AEX, CEX, and HIC resins.
  • Prior experience working with CROs, specifically doing protein production.
  • Prior experience performing analytical QC of biologics including, SEC, intact and reduced mass spectrometry, endotoxin and HCP testing, peptide mapping, released glycan analysis, and CE-SDS.
  • Experience in process development and process optimization, including expression optimization, and purification process development.
  • Proficiency in overcoming problems (i.e. low expression, aggregation, aberrant glycosylation, poor chain pairing, difficult separations) with challenging therapeutic protein production.

Scientist II Qualifications:
  • Bachelors or Masters in biology, chemistry, biochemistry or related field with typically 7+ (BS) or 5+ (MS) years of experience.
  • Prior experience with all aspects of biologics production, including expression plasmid design, stable and transient protein expression in CHO cells, primary protein capture methods using Protein A, CH1, kappa select, and secondary purification strategies using AEX, CEX, and HIC resins.
  • Prior experience working with CROs, specifically doing protein production.
  • Prior experience performing analytical QC of biologics including, SEC, intact and reduced mass spectrometry, endotoxin and HCP testing, peptide mapping, released glycan analysis, and CE-SDS.
  • Experience in process development and process optimization, including expression optimization, and purification process development.
  • Proficiency in overcoming problems (i.e. low expression, aggregation, aberrant glycosylation, poor chain pairing, difficult separations) with challenging therapeutic protein production.


Additional Information

Applicable only to applicants applying to a position in any location with pay disclosure requirements under state or local law:
  • The compensation range described below is the range of possible base pay compensation that the Company believes in good faith it will pay for this roleat the time of this posting based on the job grade for this position. Individual compensation paid within this range will depend on manyfactors including geographic location, and we may ultimately pay more or less than the posted range. This range may be modified in the future.
  • We offer a comprehensive package of benefits including paid time off (vacation, holidays, sick), medical/dental/vision insurance and 401(k) to eligible employees.
  • This job is eligible to participate in our short-term incentive programs.

Note: No amount of pay is considered to be wages or compensation until such amount isearned, vested, and determinable. The amount and availability of any bonus, commission, incentive, benefits, or any other form of compensation and benefits that areallocable to a particular employee remains in the Company's sole and absolute discretion unless and until paid and may be modified at the Company's sole and absolutediscretion, consistent with applicable law.

About AbbVie

AbbVie develops pharmaceuticals and medical devices. They provide products and services to therapeutic areas including immunology, oncology, neuroscience, eye care, virology, women's health, and gastroenterology.

AbbVie Careers

Joining AbbVie means becoming part of a global team dedicated to making a remarkable impact on patients' lives. At AbbVie, our employees are united in the pursuit of groundbreaking innovation and are committed to transforming the future of healthcare with leading-edge science.

Work You’ll Do

At AbbVie, you’ll collaborate with some of the brightest minds in the industry to solve challenging problems that have a high impact on society. Our culture fosters growth and embraces leadership and diversity training, ensuring that every team member can thrive.

Explore Job Opportunities

AbbVie offers a wide range of job opportunities and career paths, providing a platform where professionals can propel their careers forward. From research and development to marketing and sales, the potential to make a significant impact is limitless.

Internship Programs

Kickstart your career with an AbbVie internship. Our programs provide invaluable industry experience and a chance to develop essential skills in a real-world setting. Interns at AbbVie are considered integral members of the team and are given tasks that are both challenging and rewarding.

Professional Growth and Development

We believe in nurturing our team's professional growth through comprehensive training programs, leadership development opportunities, and continuous learning. Our commitment to your career growth is reflected in our robust offerings that enhance your skills and knowledge.

Benefits and Culture

AbbVie is dedicated to supporting our employees' well-being both inside and outside of work. Our benefits package includes health, financial, and social benefits that are designed to support the diverse needs of our employees. Our inclusive culture encourages collaboration and innovation, fostering a workplace where all can excel.

Hiring Process

Our hiring process is designed to ensure a match that will be beneficial both for the company and for your career aspirations. From resume submission to interview, each step is an opportunity to showcase your skills and fit with the AbbVie team.

Networking and Career Advancement

At AbbVie, networking doesn’t just enhance your career; it propels it. We encourage our employees to engage internally and externally to build relationships that foster personal and professional growth.

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Explore AbbVie Jobs

Whether you’re seeking to advance your career in a dynamic and empowering environment, or looking for a place where you can innovate, lead, and contribute to something bigger, AbbVie is the place for you. Join us in our mission to discover and deliver innovative medicines that solve serious health issues today and address the medical challenges of tomorrow.
Learn more about AbbVie
Size
50,000 employees
Market Cap
$288.5 billion
Industry
Pharmaceuticals & Biotech
Net Income
$4.6 billion
Founded
2013
5 Year Trend
+17%
Revenue
$45.8 billion
NASDAQ
ABBV
* Ladders Estimates

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