The PositionThe Scientist I is a key contributor to the Histotechnology team within the Biology Department. In partnership with the Histology Manager and cross-functional study teams, this role supports preclinical drug-development programs by planning and executing tissue collection strategies; processing, embedding, and sectioning specimens; performing histologic and immunohistochemical stains; and summarizing results for study teams. The Scientist I execute a broad range of routine and non-routine histology methods with consistent quality and reproducibility, communicates clearly with stakeholders, and exercises appropriate independence in day-to-day decision making.
This role is onsite 5 days a week in San Diego.
Responsibilities
- Study Support & Communication - Translate study requirements into practical histology work plans (sampling schemes, section levels, stain menus, controls, timelines) and present interim results to program stakeholders.
- Sample Handling & Documentation - Coordinate specimen receipt, accessioning, labeling/barcoding, and chain-of-custody; maintain complete, accurate, audit-ready records in LIMS/ELN or designated systems.
- Processing, Embedding & Sectioning - Perform routine automated tissue processing and paraffin embedding; microtome and cryosection a range of animal tissues at 5-7 bcm; complete re-cuts and serial levels as needed with minimal artifacts.
- Staining & Assay Execution - Execute H&E, special stains, and IHC/IF on manual and automated platforms, including antigen retrieval, antibody titration, protocol design, and troubleshooting; contribute to method validation (e.g., RNAscope/miRNAscope, multiplex IHC/IF).
- Microscopy, Imaging & Reporting - Perform microscopic QC, identify representative regions, and use imaging/slide scanning as available to support digital pathology; compile clear data summaries and presentations for study leads.
- Quality, Safety & Continuous Improvement - Adhere to SOPs and applicable quality expectations; follow biosafety and chemical-safety procedures; participate in deviations/CAPA as appropriate; contribute to team-based improvements (e.g., 5S/Lean).
- Instrumentation & Inventory - Operate and perform routine maintenance/calibration checks for microtomes, cryostats, stainers, printers, microscopes; track reagents/antibodies and coordinate ordering and lot qualification.
Requirements- BS or MS degree in Cell Biology, Molecular Biology, Biochemistry, or related discipline.
- BS with a minimum of seven (7) years relevant histology laboratory experience or a MS with 3+ years of academic/industry laboratory experience.
- Proficiency with microtomes, cryostats, cassette/slide printers, automated slide stainers, and microscopes; practical knowledge of tissue composition.
- Extensive experience in IHC/IF staining, protocol development, validation, and troubleshooting (including antibody titration and antigen retrieval).
- Strong project- and time-management skills with the ability to manage multiple studies and deadlines; effective written and verbal communication.
- Advanced computer skills (e.g., Excel and imaging software);
- Ability to process valuable/delicate samples and to prepare tissue for pathologist interpretation.
Preferred- Degree from an accredited Histotechnology program, HT or HTL(ASCP) certification
- Experience validating RNAscope/miRNAscope and multiplex IHC/IF across multiple tissues/species.
- Familiarity with LIMS/ELN.
- Familiarity with digital pathology and whole-slide imaging
California pay range
$115,000-$125,000 USD
Arrowhead provides competitive salaries and an excellent benefit package.
Candidates must have current, valid authorization to work in the country where this role is located.
