Vaxcyte

Scientist I, Drug Product Analytics

Vaxcyte • $129K — $140K *
San Carlos, CA 94070In-Person
Pharmaceuticals & Biotech
Less than 5 years of experience
Today
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Job Overview by Ladders

Qualifications

  • PhD, MS, or Bachelor's in Chemistry, Biochemistry, Biology, Pharmaceutical Sciences, or related field.
  • PhD with 1-2 years, MS with 5+ years, or BS with 8+ years of relevant industry experience.
  • Experience in designing, qualifying, and testing critical assay reagents.
  • Proficiency in bioassay data analysis and visualization using software tools like Excel, Prism, or JMP.
  • Experience with the analytical characterization of biologic or vaccine Drug Products.
  • Familiarity with automated liquid handling platforms is a plus.
  • Strong organizational, analytical, and problem-solving skills.

Responsibilities

  • Drive execution and optimization of Vaxcyte's multiplex immunoassay suite.
  • Design and interpret experiments for non-GxP stability studies for Drug Substance and vaccine materials.
  • Execute studies for internal release and stability samples to ensure high-quality data.
  • Develop, automate, and improve analytical assays for product characterization.
  • Analyze assay data, identify trends, and communicate findings to project teams.
  • Contribute to method development and collaborate with external analytical labs.
  • Author and review technical documentation supporting development and analytical activities.

Benefits

  • Comprehensive benefits package.
  • Equity component.
  • Collaborative and flexible work environment.
  • Opportunity to contribute to impactful vaccine development.
Full Job Description
Essential Functions:
  • Drive the execution, optimization, and continuous improvement of Vaxcyte's internal multiplex immunoassay (MSD) assay suite, including troubleshooting assay performance, improving robustness, and supporting assay lifecycle management.
  • Design, execute, and interpret experiments to support non-GxP stability studies including thermal, freeze/thaw, agitation, and container closure system evaluations for both Drug Substance and adjuvanted vaccine Drug Product materials.
  • Execute routine studies to support internal release, development, and stability samples using a variety of analytical techniques across Drug Product working groups, ensuring high-quality data generation and reporting.
  • Develop, automate, and iterate on analytical assays to support product characterization.
  • Analyze and interpret complex assay data, identify trends or deviations, and communicate findings to project teams to support development decisions.
  • Contribute to method development, qualification, and technology transfer activities, including collaboration with external analytical laboratories.
  • Author and review technical documentation including assay protocols, SOPs, reports, study plans, and technical summaries in support of development and analytical activities.
  • Support the Vaxcyte PCV and VAX-A1 programs through cross-functional collaboration with Drug Product Development, Formulation, Analytical Development, Quality, and external partners.
  • Vaxcyte is seeking a flexible and collaborative scientist comfortable managing multiple priorities in a fast-paced development environment. This role is predominantly lab-based and requires strong scientific judgment, independence in experimental execution, rigor in data analysis, and meticulous record keeping.

Requirements:
  • PhD, MS or Bachelor's degree in Chemistry, Biochemistry, Biology, Pharmaceutical Sciences, or a related scientific discipline. PhD with 1-2 years relevant industry experience; MS with 5+ years relevant industry experience; BS with 8+ years of relevant industry experience.
  • Experience with design, qualification, and testing of critical assay reagents, such as antibodies, QC samples, calibrators, amongst others
  • Experience analyzing and visualizing bioassay data using software tools such as Excel, Prism, JMP, or equivalent statistical/data analysis platforms
  • Experience designing and supporting analytical characterization of biologic or vaccine Drug Products, ideally including materials in pre-filled syringes or vials.
  • Experience supporting bioanalytical components of product release testing and stability studies.
  • Familiarity with automated liquid handling platforms will be considered an advantage.
  • Experience authoring analytical technical documentation including method protocols, SOPs, reports, and study summaries, and maintaining well-documented electronic laboratory notebooks (ELN).
  • Strong organizational skills and the ability to manage multiple projects and shifting priorities in a dynamic development environment.
  • Strong analytical and problem-solving skills with the ability to think critically
  • Strong interpersonal and communication skills, with the ability to effectively collaborate across teams and train or mentor junior analysts when needed.
  • Detail-oriented with a high level of scientific rigor and excellence in data integrity and record keeping.

Reports to: Senior Scientist, Drug Product Analytics

Location: San Carlos, CA

Work Arrangement (may be adjusted based on business needs, job responsibilities, or changes to company policy): Onsite (minimum of 4 days per week)

Compensation: The compensation package will be competitive and includes comprehensive benefits and an equity component.

Salary Range: $129,000 - $140,000 (SF Bay Area)

About Vaxcyte

Vaxcyte is a clinical-stage biotechnology company developing a new generation of vaccines to address some of the most important and deadly infectious diseases worldwide. The company's cell-free protein synthesis platform, comprising the XpressCFTM platform, is capable of rapidly generating protein antigens that can be used in vaccines to protect against bacterial and viral pathogens. Vaxcyte's lead vaccine candidate, VAX-24, is a preclinical, 24-valent pneumococcal conjugate vaccine (PCV) being developed for the prevention of pneumococcal disease. The company is also developing VAX-XP, a PCV with expanded serotype coverage, as well as vaccines for Group A Streptococcus, Group B Streptococcus, and Lyme disease.
Learn more about Vaxcyte
Size
89 employees
Market Cap
$3.6 billion
Industry
Pharmaceuticals & Biotech
Founded
2013
NASDAQ
PCVX
* Ladders Estimates

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