The Targeted Protein Degradation (TPD) Proteomics Core within the Fischer Lab at Dana-Farber Cancer Institute serves as a resource for the Cancer Biology Department, aiding investigators in answering key research questions using mass spectrometry-based proteomics. We employ quantitative chemoproteomic and interactomic approaches to identify drug targets and are continuing to expand our repertoire to meet the needs of our core users. Our core is equipped with extensive mass spectrometry equipment including timsTOF HT, timsTOF Ultra2 and Orbitrap Eclipse tribrid mass spectrometers.
The TPD Core seeks a highly motivated individual to join the team as a RESEARCH SCIENTIST, who will employ mass spectrometry-based technologies to assess the cellular proteome in response to external stimuli. This individual will be an important member of our core team and will work across a variety of different research projects focused on targeted protein degradation as a novel therapeutic modality. While we consider various mass spectrometry related backgrounds, a strong emphasis on instrument automation, systems management, and proteomics pipeline development is highly desirable.
- Lead the design and execution of proteomics experiments (eg, TMT, DIA, DDA) in collaboration with internal and external investigators
- Develop and implement automated workflows for sample preparation, instrument scheduling, data acquisition, and analysis across multiple platforms.
- Manage and maintain mass spectrometry instrumentation, including calibration, performance monitoring, and preventive maintenance to ensure high-throughput reliability.
- Integrate laboratory robotics and liquid handling systems into proteomics sample preparation pipelines to enhance throughput and reproducibility.
- Develop, optimize, and troubleshoot sample preparation workflows including whole cell proteomics, interactome analysis, and various enrichment protocols
- Analyze data using advanced pipelines (eg, DIA-NN, spectronaut, proteome discoverer) and support biological interpretation.
- Train and mentor junior staff and contribute to a culture of continuous improvement
- Ensure compliance with lab safety, QC standards, and data integrity policies
- Communicates with purchasing and may be responsible for negotiating with vendors
QUALIFICATIONS
- Ph.D in biochemistry, analytical chemistry, bioengineering or related field.
- Strong expertise in mass spectrometry-based proteomics and data analysis
- Hands on experience operating Thermo and/or Bruker mass spectrometers is required
- Demonstrated experience with laboratory automation, robotics, or pipeline development (e.g., Hamilton, Opentrons, or custom scripting for workflow automation).
- Proficiency with quantitative proteomics (label-free, TMT, DIA) and enrichment techniques.
- Familiarity with data analysis software and scripting (DIA-NN, Proteome Discoverer, R, Python).
- Excellent organizational, troubleshooting, and communication skills.
- Proven ability to work collaboratively across interdisciplinary teams and manage multiple projects simultaneously.
License/Certification/Registration Required: None
Supervisory Responsibilities: No
Patient Contact: None
The hiring range is based on market pay structures, with individual salaries determined by factors such as business needs, market conditions, internal equity, and based on the candidate's relevant experience, skills and qualifications.
For union positions, the pay range is determined by the Collective Bargaining Agreement (CBA).
$80,000.00 - $95,900.00
