Job Family:Scientist
Travel Required:None
Clearance Required:Ability to Obtain Public Trust
What You Will Do:We are seeking a Scientist to develop, optimize, and conduct microdissections of human blood vessels from tissue specimens as part of the Institutional Review Board (IRB)-approved or IRB exempt studies and overall laboratory research support for Laboratory of Malaria and Vector Research (LMVR). This is a full-time, on-site role in Rockville, MD.
- Conduct microdissections of human vessels, prepare tissue for single-cell analysis of vascular cells, genetically manipulate human vessels, and assess function through molecular, imaging, and physiologic evaluations.
- Culture vascular cells, prepare cells for single-cell analysis, perform genetic manipulation of cultured cells, and assess function using molecular, imaging, and physiologic evaluations.
- Develop, refine, and perform microdissections of human blood vessels from tissue specimens for IRB-approved or exempt studies.
- Develop, refine, and conduct vascular cell culture and co-culture methods, and optimize approaches for studying human vessels and cultured cells at the single-cell level in IRB-approved or exempt studies.
- Characterize cultured cells using imaging, gene expression, and/or molecular sensors.
- Perform vascular phenotyping of rodent models, including mouse models of human diseases or conditions.
- Perform biochemical characterization of protein-protein interactions involved in vascular cell signaling.
- Work with staff on the interpretation of experiments performed by research scientists.
- Independently direct and conduct special research projects that have a high priority for the laboratory with special emphasis on the development of novel research treatments.
- Calibrate, maintain and troubleshoot instruments and equipment in the laboratory.
- Manage scientific equipment and resources, including reagents, frozen cell stocks, and animal samples, by overseeing acquisition, documentation, and storage.
- Write technical reports and prepare manuscripts.
- Oversee project data quality; analyze and interpret project data.
- Maintain a detailed and up-to-date electronic laboratory notebook detailing all experiments.
- Develop and evaluate pharmacologic strategies that target protein-protein interactions to alter vascular function in human vessels, cells, or animal models of vascular physiology or disease.
- Prepare oral presentations and posters for internal and external groups/conferences.
- Co-author manuscripts on research projects; publish in peer-reviewed journals.
- Write papers and abstracts detailing research efforts and results for publication in peer-reviewed journals; prepare PowerPoint presentations as appropriate.
- Produce research reports and regularly communicate results to staff and collaborators.
- Train staff on proper equipment use and a broad range of laboratory techniques.
- Incumbent capture, no other candidates were considered due to incumbent candidate identified. They meet the labor category requirements provided by the customer.
What You Will Need:- Master's degree in Biochemical Sciences or related field.
- A minimum of SIX (6) years of laboratory research experience.
- Experience with cell culture and vascular biology research techniques.
- Proficiency with Microsoft Office Suite (PowerPoint, Outlook, Excel, Word).
- Knowledge of Good Clinical Practice (GCP).
- Ability to analyze and interpret complex scientific data and produce technical reports.
- Strong written and verbal communication skills, including scientific publishing and presentations.
- Ability to work independently and collaboratively in a research laboratory environment.
- Must be able to obtain and maintain a Federal or DoD "public trust"; candidates must receive approved adjudication prior to onboarding with Guidehouse. Candidates with an active public trust or suitability are preferred.
What Would Be Nice To Have:- Experience with single-cell analysis techniques.
- Experience working with rodent models of disease.
- Background in genetic manipulation and molecular biology techniques.
- Experience presenting at national scientific meetings or publishing in peer-reviewed journals.
- Prior experience mentoring or training laboratory staff.
The annual salary range for this position is $130,000.00-$216,000.00. Compensation decisions depend on a wide range of factors, including but not limited to skill sets, experience and training, security clearances, licensure and certifications, and other business and organizational needs.
What We Offer:Guidehouse offers a comprehensive, total rewards package that includes competitive compensation and a flexible benefits package that reflects our commitment to creating a diverse and supportive workplace.
Benefits include:
- Medical, Rx, Dental & Vision Insurance
- Personal and Family Sick Time & Company Paid Holidays
- Parental Leave
- 401(k) Retirement Plan
- Group Term Life and Travel Assistance
- Voluntary Life and AD&D Insurance
- Health Savings Account, Health Care & Dependent Care Flexible Spending Accounts
- Transit and Parking Commuter Benefits
- Short-Term & Long-Term Disability
- Tuition Reimbursement, Personal Development, Certifications & Learning Opportunities
- Employee Referral Program
- Corporate Sponsored Events & Community Outreach
- Care.com annual membership
- Employee Assistance Program
- Supplemental Benefits via Corestream (Critical Care, Hospital Indemnity, Accident Insurance, Legal Assistance and ID theft protection, etc.)
- Position may be eligible for a discretionary variable incentive bonus
