Massachusetts Institute of Technology

Research Scientist 3

Massachusetts Institute of Technology • $95K — $115K *
Cambridge, MA 02139In-Person
Pharmaceuticals & Biotech
Less than 5 years of experience
Today
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Job Overview by Ladders

Qualifications

  • PhD in proteomics, protein chemistry, molecular biology, analytical chemistry, or related field.
  • Expertise in mass spectrometry-based techniques for proteomics or peptidomics.
  • Experience in developing and optimizing specific assays for proteomics or peptidomics.
  • Hands-on experience with LC-MS instrumentation and troubleshooting.
  • Proficiency in data analysis software such as PEAKS, FragPipe, DIA-NN, or Skyline.
  • Demonstrated ability to analyze large datasets using statistical methods.
  • Proven scientific productivity evidenced by publications or method development.

Responsibilities

  • Develop and optimize quantitative and qualitative assays for proteomics and peptidomics.
  • Prepare biological samples for analysis using state-of-the-art techniques.
  • Operate, maintain, and troubleshoot mass spectrometry instruments.
  • Analyze mass spectrometry data with advanced software tools.
  • Lead research projects from initial concept to implementation.
  • Contribute to the design of experiments and research strategies.
  • Collaborate across interdisciplinary teams and mentor junior researchers.

Benefits

  • Opportunity to work at the prestigious Broad Institute of MIT and Harvard.
  • Engagement in cutting-edge research in programmable therapeutics.
  • Access to state-of-the-art laboratory facilities and equipment.
  • Collaborative environment with interdisciplinary teams.
  • Opportunity for career advancement through mentorship and leadership roles.
Full Job Description
Posting Description
RESEARCH SCIENTIST 3, The Zhang Lab - Broad Institute of MIT and Harvard , with expertise in proteomics and peptidomes. This individual will develop and optimize quantitative and qualitative proteomic, peptidomic, and immunopeptidomic assays supporting research in programmable therapeutics and human health. Key responsibilities include preparing biological samples, operating and maintaining LC-MS instruments, troubleshooting workflows, and analyzing mass spectrometry data using platforms such as PEAKS, FragPipe, DIA-NN, and Skyline. The scientist will lead projects from concept through execution, contribute to experimental design and research strategy, collaborate across teams, and mentor junior researchers.

The full job description is available, here: https://www.dropbox.com/scl/fi/lwyc355ourlsakli1a9yb/Proteomics-Research-Scientist.pdf?rlkey=9m3v8qz6ysozfad42lntkcmyu&st=8yyrb9e1&dl=0

Job Requirements
REQUIRED : PhD or equivalent training in proteomics, protein chemistry, molecular biology, analytical chemistry, or a related field; expertise in mass spectrometry-based proteomics or peptidomics; experience developing and optimizing proteomic or peptidomic assays; hands-on experience operating and troubleshooting LC-MS instrumentation; proficiency with PEAKS, FragPipe, DIA-NN, Skyline, or similar software; ability to analyze large datasets and apply appropriate statistical methods; record of scientific productivity through publications, method development, or related contributions; strong experimental design, organization, documentation, and project-management skills; ability to work independently, manage multiple projects, and collaborate effectively; excellent written and verbal communication skills. PREFERRED : Experience with immunopeptidomics and mentoring junior scientists.

9/23/2026

About Massachusetts Institute of Technology

The Massachusetts Institute of Technology (MIT) is a private research university located in Cambridge, Massachusetts. MIT is a member of the Association of American Universities (AAU) and is classified among "R1: Doctoral Universities – Very high research activity". The university is known for its strong emphasis on scientific and technological research and its engineering programs. MIT was founded in 1861 and has a long history of innovation and entrepreneurship. The university has produced numerous Nobel laureates, Rhodes Scholars, and MacArthur Fellows.
Learn more about Massachusetts Institute of Technology
Size
13,000 employees
Industry
Education, Government & Non-Profit
* Ladders Estimates

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