Protein Purification/Expression Biochemist

Cogent Scientific

$80K — $95K *
Pharmaceuticals & Biotech
Less than 5 years of experience
Job Overview by Ladders

Qualifications

  • BS in Biochemistry, Molecular/Cellular Biology, or related field; MS considered with relevant experience.
  • 3-5 years of industry lab experience or 1-2 years with a master's degree.
  • Demonstrated expertise in protein expression in bacterial and eukaryotic systems.
  • Proficient in protein purification techniques and familiar with Cytiva AKTA FPLC and Unicorn software.
  • Strong communication skills, both written and verbal.

Responsibilities

  • Design and conduct experiments for recombinant protein expression and production.
  • Develop quality protocols for well-characterized proteins for structural and functional studies.
  • Review and optimize purification processes to enhance yields and consistency.
  • Analyze experimental data using E-notebook and share findings promptly.
  • Collaborate across functions to tackle complex problem-solving challenges.

Benefits

  • Full-time day shift schedule (approx. 8a-5p).
  • Opportunity to work in a multidisciplinary and fast-paced environment.
  • Collaborative team culture that values communication and innovation.
Full Job Description
We currently have a role available for a Protein Purification/Expression Biochemist to join our San Diego team.

Job duties include, but are not limited to, the following:

  • Designing and conducting experiments for expression and production processes of recombinant proteins, both on a small and large scale.
    • Prior experience with protein expression in bacteria and eukaryotic systems required.
    • Experience with protein purification techniques, including column chromatography (affinity, size exclusion, ion exchange, hydrophobic interaction, etc.), ultrafiltration, and dialysis as well as familiarity with Cytiva AKTA FPLC system and Unicorn software are required.
    • Must be able to lift up to 20lb.
  • Understanding the quality requirements for proteins used in structural and functional studies, and developing protocols to deliver well-characterized proteins accordingly.
    • Knowledge of biophysical techniques for protein characterization, such as mass photometry/spectroscopy, differential scanning fluorimetry (DSF), HPLC, isothermal titration calorimetry (ITC), and surface plasmon resonance (SPR), is a plus.
  • Reviewing and optimizing purification processes and methods to improve yields, reduce costs, and produce consistent products.
  • Analyzing and capturing experimental data using E-notebook, and sharing data in a timely manner.


Job requirements include, but are not limited to:
  • BS-Biochemistry, Molecular/Cellular Biology or a related field with 3-5 years of industrial lab experience outside of academia. MS in the same fields with 1-2 years of industrial lab experience outside of academia will also be considered.
  • Excellent communication skills - verbal and written.
  • Works well both as a team and as an individual.
  • Demonstration of excellent team player skills, very strong attention to detail, very strong problem-solving skills, a high level of learning agility, and the ability to work across functions. The ideal candidate will be enthusiastic and self-motivated, with the leadership and communication skills necessary to operate effectively in a fast-paced multidisciplinary environment with flexibility and an adaptable approach to goal delivery.


This is a day shift position (approx. 8a-5p local time).

This job posting will remain open until 9/28/2026 or until a qualified candidate has been selected, whichever comes first.

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