Program Manager

Sigma Systems, Inc

$100K — $130K *
Pharmaceuticals & Biotech
5 - 7 years of experience
Job Overview by Ladders

Qualifications

  • Bachelor's Degree in a relevant engineering or technical discipline.
  • Extensive experience managing large-scale capital projects.
  • Proven track record of delivering projects with a capital investment exceeding $100 million.
  • In-depth understanding of Front-End Loading (FEL) processes and project lifecycles.
  • Experience in managing engineering, construction, commissioning, and startup activities.
  • Strong communication and stakeholder management skills.
  • Ability to perform effectively in high-pressure environments.

Responsibilities

  • Lead end-to-end delivery of a large-scale vaccine manufacturing facility project.
  • Manage project scope, schedule, budget, resources, and deliverables.
  • Oversee project planning, governance, risk management, and reporting activities.
  • Ensure timely achievement of project milestones within budget constraints.
  • Serve as primary liaison among various project stakeholders and contractors.
  • Coordinate design reviews and construction activities.
  • Monitor progress, addressing risks, delays, and resource issues proactively.

Benefits

  • Opportunity to work on large-scale vaccine manufacturing projects.
  • Collaborate with cross-functional teams across multiple departments.
  • Gain experience in a dynamic and fast-paced pharmaceutical environment.
  • Contribute to significant advancements in biotechnology and life sciences.
  • Work onsite and engage directly with all phases of project execution.
Full Job Description
About the job Program Manager

37261403 Program Manager - Capital Projects | Pharmaceutical Manufacturing | St. Joseph, MO | 24-Month Contract

Location: St. Joseph, MO
Duration: 24-Month Contract
Schedule: 1st Shift | Minimum 45 Hours Per Week
Work Arrangement: 100% Onsite

Program Manager - Capital Projects Overview

This is an exciting opportunity for a seasoned capital projects professional with expertise in pharmaceutical manufacturing, biotechnology, life sciences, industrial construction, or large-scale facility expansions. The selected candidate will oversee all phases of project execution, from planning and design through construction, validation, commissioning, and operational readiness.

The ideal candidate will possess a strong background managing capital projects exceeding $100 million, working with cross-functional stakeholders, engineering teams, EPC firms, contractors, and executive leadership.

Key Responsibilities

Capital Project Leadership
  • Lead end-to-end project delivery for the design, construction, commissioning, and startup of a large-scale vaccine manufacturing facility.
  • Manage project scope, schedule, budget, resources, and deliverables to ensure successful execution.
  • Oversee project planning activities, governance processes, risk management strategies, and performance reporting.
  • Ensure project milestones are achieved on time and within budget.

Construction & Engineering Management
  • Serve as the primary liaison between project stakeholders, architects, engineering firms, EPC contractors, construction teams, and equipment vendors.
  • Coordinate design reviews, construction activities, equipment installation, commissioning, and facility startup activities.
  • Monitor project progress and proactively resolve risks, delays, and resource constraints.

Cross-Functional Leadership
  • Lead collaboration across Engineering, Operations, Quality Assurance, Validation, Manufacturing, Regulatory Affairs, Procurement, and Supply Chain teams.
  • Influence executive stakeholders and drive strategic decision-making throughout the project lifecycle.
  • Provide leadership across multiple departments and functional teams, both directly and indirectly.

Governance & Risk Management
  • Establish project governance structures and reporting mechanisms.
  • Maintain risk registers, mitigation plans, issue logs, and executive reporting dashboards.
  • Ensure adherence to project controls, quality standards, and regulatory requirements.

Required Qualifications
  • Bachelor's Degree in Engineering, Construction Management, Mechanical Engineering, Chemical Engineering, Biomedical Engineering, or related technical discipline.
  • Extensive experience managing large-scale capital projects, facility expansions, or new construction projects.
  • Proven experience delivering projects exceeding $100 million in capital investment.
  • Strong understanding of Front-End Loading (FEL) processes and capital project lifecycles.
  • Experience managing engineering, construction, commissioning, and startup activities.
  • Demonstrated success leading cross-functional project teams.
  • Exceptional communication, stakeholder management, and leadership skills.
  • Strong analytical, organizational, and problem-solving abilities.
  • Ability to work effectively in fast-paced, high-pressure project environments.

Preferred Qualifications
  • Pharmaceutical manufacturing experience.
  • Biotechnology or vaccine manufacturing facility experience.
  • Life sciences, biologics, medical device, or regulated manufacturing industry experience.
  • Experience working with EPC firms, contractors, and equipment suppliers.
  • Familiarity with GMP-regulated manufacturing environments.
  • Experience supporting facility commissioning, qualification, and validation activities.

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