Process Development Senior Scientist.

Let’s do this. Let’s change the world. In this vital role you will join our Drug Substance Technologies - Synthetics (DSTS) group at either our Thousand Oaks, California or Cambridge, Massachusetts campus. In this dynamic role, the individual will drive innovative solutions to support manufacturing of therapeutic peptides at various stages of development; pre-IND through commercial production. The successful candidate will have a strong background and experience in industrialization of solid phase peptide synthesis, ideally complemented with experience in peptide purification, isolation, and characterization techniques. The individual will be highly motivated and team-oriented with a proven track record of scientific innovation and achievement.

Responsibilities:

• Work effectively with a diverse team of synthetic chemists, chemical engineers and analytical chemists to develop scalable synthetic processes utilizing solid phase peptide synthesis
• Drive technology innovation in solid-phase synthesis, purification, and characterization of synthetic peptides
• Support cGMP manufacturing and technology transfer to external contract manufacturers
• Advance enabling technologies to accelerate pharmaceutical development and to improve sustainability and process efficiency
• Ensure process performance through process understanding, modeling and characterization
• Contribute to drug substance development teams by providing experimental results, technical updates, documentation, data interpretation, recommendations, etc.
• Work cross-functionally to deliver regulatory documents and support regulatory filings
• Serve as a technical expert and keep current in the field of solid phase peptide synthesis
• Work independently in advancing projects and studies within required deadlines.

We are all different, yet we all use our unique contributions to serve patients. The dynamic professional we seek is an individual with these qualifications.

Basic Qualifications:

Doctorate degree PhD OR PharmD OR MD [and relevant post-doc where applicable]
OR
Master’s degree and 3 years of scientific experience
OR
Bachelor’s degree and 5 years of scientific experience

Preferred Qualifications:

• Ph.D. in organic chemistry, biochemistry, or chemical engineering with expertise in synthetic peptide process development
• Extensive hands-on expertise in the synthesis and purification of synthetic peptides produced by solid phase synthesis
• Experience within the pharmaceutical/biotech industry developing solid phase peptide synthesis processes and scaling/transferring the process into GMP manufacturing
• Proficiency in analytical characterization techniques such as Hydrophobic Interaction Chromatography (HIC)-HPLC, Size Exclusion Chromatography (SEC), Liquid Chromatography–Mass Spectrometry (LC-MS), Ion-Exchange (IEX), and Reversed Phase (RP)-HPLC.
• Familiarity with laboratory automation, data analysis and visualization techniques and tools
• Track record of peer-reviewed publications and research presentations
• Demonstrated ability to work within a dynamic and interdisciplinary environment to achieve results
• Excellent written and verbal communication skills, ability to multitask, effectively plan and follow through on complex projects
• A research summary included with CV is strongly encouraged

As we work to develop treatments that take care of others, we also work to care for your professional and personal growth and well-being. From our competitive benefits to our collaborative culture, we’ll support your journey every step of the way.

The expected annual salary range for this role in the U.S. (excluding Puerto Rico) is posted. Actual salary will vary based on several factors including but not limited to, relevant skills, experience, and qualifications.

In addition to the base salary, Amgen offers a Total Rewards Plan, based on eligibility, comprising of health and welfare plans for staff and eligible dependents, financial plans with opportunities to save towards retirement or other goals, work/life balance, and career development opportunities that may include:

• A comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions, group medical, dental and vision coverage, life and disability insurance, and flexible spending accounts
• A discretionary annual bonus program, or for field sales representatives, a sales-based incentive plan
• Stock-based long-term incentives
• Award-winning time-off plans
• Flexible work models where possible. Refer to the Work Location Type in the job posting to see if this applies.

Salary Range