Job Description

We are seeking an accomplished and highly motivated Principal Scientist to provide strategic and scientific biomarker leadership across programs within the Cardiovascular & Metabolic and Infectious Diseases/Vaccines portfolios.

This role will lead the design, execution, analysis, and communication of translational and clinical biomarker strategies across programs spanning early through late clinical development.

The successful candidate will develop decision-centric biomarker strategies that integrate therapeutic mechanism, disease biology, pharmacodynamics, patient heterogeneity, dose and regimen selection, clinical endpoints, and opportunities for precision medicine. Biomarker plans should focus on generating high-value, interpretable evidence that informs program decisions rather than data generation alone.

Key Responsibilities

• Significant experience developing and executing translational or clinical biomarker strategies in drug or vaccine development.

• Scientific expertise relevant to one or more areas within cardiovascular disease, metabolic disease, infectious diseases, vaccines, immunology, or related disciplines.

• Demonstrated ability to translate scientific hypotheses into biomarker strategies that inform clinical development decisions.

• Strong understanding of the relationship between mechanism of action, disease biology, pharmacology, biomarkers, clinical endpoints, and development strategy.

• Ability to lead cross-functional scientific work in a matrixed environment and influence without direct authority.

• Strong analytical and problem-solving skills, including the ability to synthesize complex datasets into clear, decision-oriented conclusions.

• Ability to prioritize high-value, decision-enabling biomarker work and distinguish it from lower-priority exploratory activities.

• Excellent written and verbal communication skills and the ability to communicate scientific strategy to stakeholders.

• Working knowledge of biostatistics, bioinformatics, quantitative sciences, and multidimensional biomarker data analysis.

• Strategic mindset with a focus on scientific rigor, prioritization, scalability, and generation of actionable evidence.

Preferred Experience and Skills

• Experience supporting programs across multiple stages of clinical development.

• Experience with pharmacodynamic, predictive, prognostic, patient-stratification, or precision-medicine biomarker strategies.

• Experience in cardiovascular/metabolic drug development and/or infectious disease and vaccine development.

• Experience working across multiple programs or therapeutic areas.

• Experience mentoring or providing scientific direction to other scientists.

Required Skills:

Preferred Skills:

Current Employees apply

Current Contingent Workers apply

US and Puerto Rico Residents Only:

The salary range for this role is

This is the lowest to highest salary we in good faith believe we would pay for this role at the time of this posting. An employee’s position within the salary range will be based on several factors including, but not limited to relevant education, qualifications, certifications, experience, skills, geographic location, government requirements, and business or organizational needs.

The successful candidate will be eligible for annual bonus and long-term incentive, if applicable.

We offer a comprehensive package of benefits.  Available benefits include medical, dental, vision healthcare and other insurance benefits (for employee and family), retirement benefits, including 401(k), paid holidays, vacation, and compassionate and sick days. More information about benefits is available at .

You can apply for this role through (or via the Workday Jobs Hub if you are a current employee). The application deadline for this position is stated on this posting.

San Francisco Residents Only: We will consider qualified applicants with arrest and conviction records for employment in compliance with the San Francisco Fair Chance Ordinance

Los Angeles Residents Only: We will consider for employment all qualified applicants, including those with criminal histories, in a manner consistent with the requirements of applicable state and local laws, including the City of Los Angeles’ Fair Chance Initiative for Hiring Ordinance

Search Firm Representatives Please Read Carefully 
Merck & Co., Inc., Rahway, NJ, USA, also known as Merck Sharp & Dohme LLC, Rahway, NJ, USA, does not accept unsolicited assistance from search firms for employment opportunities. All CVs / resumes submitted by search firms to any employee at our company without a valid written search agreement in place for this position will be deemed the sole property of our company.  No fee will be paid in the event a candidate is hired by our company as a result of an agency referral where no pre-existing agreement is in place. Where agency agreements are in place, introductions are position specific. Please, no phone calls or emails. 

Employee Status:

Relocation:

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