Job Function: Discovery & Pre-Clinical/Clinical Development
Job Sub Function: Biotherapeutics R&D
Job Category:Scientific/Technology
All Job Posting Locations:Spring House, Pennsylvania, United States of America
Job Description:We are searching for the best talent for a Principal Scientist, Biologics Discovery in Spring House, PA.Job Description
Position Summary:This position is dedicated to advancing the discovery and development of innovative biotherapeutics targeting unmet medical needs through immune-mediated approaches. As a key contributor, you will leverage your expertise in Immunobiology and T-cell biology to support portfolio programs and drive the success of discovery initiatives.
You will be responsible for:- Leading or actively participating in project teams to progress discovery portfolio projects.
- Driving technology development efforts for multispecific antibody platforms and validating readiness for portfolio inclusion.
- Designing, conducting, and interpreting in vitro immune cell functional assays and related experimental studies.
- Presenting and defending scientific findings independently within multidisciplinary teams and initiatives.
- Authoring patent applications, manuscripts, study protocols, SOPs, and technical reports.
- Managing and mentoring scientific staff.
Qualifications / Requirements:Education:- Ph.D. degree in life sciences (molecular biology, biochemistry, immunology, or a related discipline) with 4+ years post-doctoral experience OR Master's Degree in life sciences with at least 6+ years of experience is required.
Required:- Extensive understanding of immunology, including in vitro and in vivo models relevant to immuno-oncology and autoimmune disease.
- Demonstrated experience with immune cell based assays such as multi-color flow cytometry, cytotoxicity, and multiplex cytokine assays.
- Experience developing novel, complex, and high-throughput immune assays for functional characterization and MOA studies.
- Ability to work effectively in a matrixed environment-both within the group and across the broader organization.
- Strong dedication, motivation, and a collaborative approach to advancing therapeutic innovation.
- Commitment to continuous learning and scientific excellence.
- Excellent analytical and problem-solving skills for experimental design and data interpretation.
- Exceptional communication skills, with the ability to present complex data clearly and concisely is required.
Preferred:- Experience in end-to-end drug development processes is highly preferred.
- Industry experience is highly preferred.
This job posting is anticipated to close on March 6, 2026. The Company may however extend this time-period, in which case the posting will remain available on https://www.careers.jnj.com to accept additional applications.
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Required Skills: Preferred Skills:Analytical Reasoning, Biochemistry, Biotechnology, Chemistry, Manufacturing, and Control (CMC), Clinical Research and Regulations, Clinical Trial Designs, Coaching, Critical Thinking, Drug Discovery Development, Emerging Technologies, Molecular Diagnostics, Organizing, Pharmacovigilance, Presentation Design, Process Improvements, Productivity Planning, Scientific Research
