Principal Information System Engineer

Treeline Biosciences

$180K — $196K *
Information Technology
8 - 10 years of experience
Job Overview by Ladders

Qualifications

  • Bachelor's degree in IT, Computer Science, or related field or equivalent experience.
  • 8-10+ years of experience in systems administration or IT operations.
  • Extensive knowledge across Windows, Mac, databases, storage, security, and cloud services.
  • Proven hands-on experience with Microsoft 365, Intune, and Entra ID.
  • Familiar with MFA and endpoint security solutions such as Okta.
  • Strong skills in PowerShell scripting and troubleshooting complex issues.
  • Relevant certifications are beneficial.

Responsibilities

  • Act as the primary technical escalation point for the IT team, providing user support as needed.
  • Lead and execute complex technical projects hands-on.
  • Provide secondary decision-making support in IT Operations regarding tools and vendors.
  • Administer and optimize enterprise cloud technologies including identity and security solutions.
  • Oversee Microsoft 365 and Intune environments with a focus on security configurations.
  • Manage identity solutions and ensure secure access to company systems.
  • Automate tasks with PowerShell to enhance efficiency and reduce burdens on the team.
  • Collaborate across multiple departments and geographical locations to solve issues and improve IT solutions.

Benefits

  • Opportunity to work in a growing biotech startup environment.
  • Collaborative, diverse team dynamics with a focus on innovation.
  • Potential for career development within the fast-evolving IT landscape.
  • Hands-on involvement in impactful technical initiatives.
  • Exposure to cutting-edge technologies and robust cloud solutions.
Full Job Description
Summary

We are seeking an experienced and customer-focused Principal InformationSystem Engineer to join our IT team. The ideal candidate will have strong experience managing modern workplace technologies and troubleshooting complex technical issues. This role reports to our Director, IT Operations and will work closely with both our in-house engineers and Managed Service Providers (MSPs) supporting Treeliners from every department across multiple countries.

Responsibilities
  • Serve as the primary technical escalation point for the IT organization, including providing hands-on support to end users as needed.
  • Hands-on leadership for complex technical initiatives.
  • Serve as a secondary technical decision-maker for IT Operations, providing recommendations to the Director on tooling, standards, and vendor issues.
  • Administer, support, and optimize cloud-based enterprise technologies, including endpoint, identity, and security management solutions.
  • Manage modern workplace technologies and troubleshoot complex technical issues.
  • Administer and maintain Microsoft 365, Microsoft Intune, and Microsoft Entra ID environments, including Conditional Access Policies and endpoint security configurations.
  • Manage identity and access solutions, including Okta and Multi-Factor Authentication (MFA), to safeguard Treeline systems and data.
  • Develop and maintain PowerShell scripts to automate routine administrative tasks and improve operational efficiency.
  • Partner with in-house engineers and MSPs to support employees across multiple departments and countries.
  • Maintain accurate documentation, ticket updates, and knowledge base articles in accordance with established ITSM processes.
  • Collaborate with local and remote coworkers and vendors to design, implement, and continuously improve IT solutions.

Qualifications
  • Bachelor's degree in Information Technology, Computer Science, or related field, or equivalent work experience.
  • 8-10+ years of experience in systems administration, endpoint management, identity management, or IT operations.
  • A broad range of overall IT experience, including Windows, Mac, Databases, Storage, Security, Networking and public clouds.
  • Strong hands-on experience with the following or similar:
  • Microsoft 365 Administration
  • Microsoft Intune
  • ManageEngine Endpoint Central
  • Microsoft Entra ID, including Conditional Access Policies
  • Okta
  • Endpoint security and device management
  • Multi-Factor Authentication (MFA)
  • PowerShell (Basic to Intermediate)
  • Strong troubleshooting, problem-solving, and analytical skills.
  • A track record of taking ownership in issue resolution. No problem is too big or too small.
  • Organized and detail orientated.
  • Excellent written and verbal communication skills, including clear documentation, ticket updates, and knowledge base contributions.
  • Familiarity with ticketing systems and ITSM processes
  • Experience working collaboratively with coworkers and vendors, both local and remote, while also being effective working independently.
  • You are curious, creative, and innovative and want to continuously improve our processes.
  • Previous experience working in a biotech startup or biopharmaceutical.
  • Related certifications are a plus
  • Ability to explain technical issues clearly to non-technical users
  • Patient, customer-focused mindset with a commitment to service quality
  • Ability to prioritize tasks and manage multiple issues simultaneously

This position is classified as exempt. The anticipated annual base salary range for candidates who will work in Watertown is $180,250 to $196,751. The final base salary offered to the successful candidate will be dependent upon several factors that may include but are not limited to the type and length of experience within the job, and other factors. Treeline Biosciences is a multi-state employer, and this salary range may not reflect positions that work in other cities or states.

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