Principal Hardware Engineer, Precision Instrumentation

Astera

$120K — $160K *
Aerospace & Defense
Less than 5 years of experience
Job Overview by Ladders

Qualifications

  • 5-7 years in precision hardware development, preferably in medical devices, robotics, aerospace, or similar fields.
  • Proven experience owning complex instruments from concept through reliable operation.
  • Strong skills in mechanical design and fabrication, with added expertise in electronics or optics.
  • Experience in equipping and managing a workshop or prototyping facility.
  • Demonstrated ability to mentor engineers and influence engineering culture.

Responsibilities

  • Design and construct advanced precision mechanical systems for scientific experiments.
  • Develop components for custom microscopy and optical systems, focusing on alignment and mounting.
  • Iterate on custom laboratory instruments and experiment-specific robotics in collaboration with scientists.
  • Create and manage electronic systems that connect mechanical components to data acquisition platforms.
  • Lead the development and management of the design and prototyping facility, enhancing workflows and tooling.

Benefits

  • Opportunity to work at the forefront of experimental design with direct contributions to groundbreaking research.
  • Collaborative environment working alongside scientists to bring concepts to life.
  • Autonomy in driving technical direction and shaping the engineering organization.
  • Possibility for professional growth through mentoring and leadership opportunities.
Full Job Description
About the Role

You will design and build the physical systems our experiments depend on, most of which don't exist commercially. Working directly with scientists, you will develop a design, build it, and iterate until it works for the experiment. Some projects are well specified from the start; others begin as a rough idea that takes shape as you build. The work crosses mechanical design, fabrication, electronics, and optics, often within a single project. You do not need a background in neuroscience to apply; we are looking for world-class generalists who have built precision hardware in demanding industry settings, and who pick up the science as they go.

This is a principal-level role. You will own complex instruments end-to-end and drive technical direction. You will also help equip and run our design and prototyping facility, set the engineering culture and standards as the hardware team grows, mentor and hire the engineers who join you, and shape what experiments are possible here. You will report to [reporting line; confirm] and work directly with our scientists.

What You Will Build
  • Precision mechanical systems for experiments, such as titanium microfixtures, micrometer-precision electrode drives, and custom machined jigs.
  • Components for custom microscopes and optical systems, including alignment and mounting hardware.
  • Custom laboratory instrumentation and surgical or experimental robotics, designed and iterated alongside the scientists who depend on them.
  • Electronics and control hardware that interface mechanical systems with data acquisition and the rest of the research stack.
  • The design and prototyping facility itself: tooling, workflows, and fabrication capabilities that determine how fast the team can move.


What We Are Looking For
  • A world-class generalist and hands-on problem-solver who has built precision hardware in a high-precision industry, ideally medical devices, robotics, aerospace, semiconductor capital equipment, or commercial scientific instrumentation. You have designed and built hardware that other people relied on for real work, and you kept it running.
  • Resourcefulness about getting things built quickly: you will machine one part, 3D-print the next, and send a job out for what is better outsourced.
  • Comfort working from a rough idea rather than a finished spec, figuring out the path to a working instrument together with the people who need it.
  • Deep fundamentals in mechanical design and fabrication, with real working ability in electronics or optics. You do not restrict yourself to what is familiar.
  • Intellectually curious, collaborative, and eager to learn the science around you.
  • A track record of owning complex instruments end-to-end, from concept through fabrication, integration, and reliable operation.
  • Experience making and defending design tradeoffs across performance, manufacturability, cost, and timeline.
  • Experience equipping and running a workshop, makerspace, or prototyping facility.
  • A history of mentoring engineers or setting engineering culture and standards.


Bonus
  • Experience with small precise parts, difficult materials, tight tolerances, precision motion, or optical alignment.
  • Hands-on electronics design (PCB layout, embedded systems, sensor/actuator integration).
  • Familiarity with electrophysiology or other low-volume, high-complexity hardware environments.
  • CAD/CAM proficiency with hands-on machining (CNC, lathe, mill) and 3D printing.
  • Experience integrating hardware with data acquisition systems (DAQ, TTL synchronization, serial/SPI protocols).


Education

Backgrounds in mechanical, electrical, or biomedical engineering, physics, or related fields are all welcome. Graduate work or research experience is a plus but not required.

Similar Jobs

More Jobs at Astera

More Aerospace & Defense Jobs

Find similar Principal Hardware Engineer, Precision Instrumentation jobs: