McKesson

Principal Engineer (Healthcare)

McKesson$149K — $249K *
US-AnywhereRemote in Texas, US
Healthcare
8 - 10 years of experience
Job Overview by Ladders

Qualifications

  • Bachelor's degree in Computer Science, Engineering, or related field; advanced degree preferred.
  • 10+ years of software engineering experience with leadership on complex distributed systems.
  • Deep expertise in data engineering, software engineering, and AI/ML engineering; fluency across all three.
  • Proven ability to design and operate scalable distributed systems and data-intensive applications.
  • Hands-on experience with TensorFlow, PyTorch, or scikit-learn for building AI/ML systems.
  • Proficiency in modern programming languages like Python, Java, C#, Go, or TypeScript.
  • Excellent communication and influencing skills across engineering and executive levels.

Responsibilities

  • Design cross-domain architecture for complex systems, ensuring scalability and security.
  • Lead data engineering efforts, handling large volumes of genomic and clinical data.
  • Build robust production software across the entire technology stack.
  • Productionize AI/ML capabilities, establishing MLOps foundations for dependable systems.
  • Champion code quality, testing, security, and regulatory compliance standards.
  • Shape technical roadmaps and strategic build/buy decisions.
  • Mentor engineers and promote best practices across the organization.
  • Stay current with new technologies and evaluate those for measurable improvements.

Benefits

  • Comprehensive health and wellness programs.
  • Flexible work environment and remote work options.
  • Professional development opportunities and continued education support.
  • Generous paid time off and holiday policies.
  • Retirement savings plan with company match.
Full Job Description
About the Role

We are seeking a Principal Engineer to serve as a hands-on technical leader across the full breadth of our platform - data engineering, software engineering, and AI engineering. This is our most senior individual-contributor role and is reserved for engineers who combine deep technical mastery with organization-wide influence.

The Principal Engineer sets technical direction, designs systems that operate reliably and securely at scale, and raises the engineering bar across teams. You will partner closely with engineering leadership, product management, and clinical and scientific stakeholders to solve the hardest problems in precision oncology - from large-scale genomic data pipelines to production AI/ML systems that support clinical and research decision-making. This position reports to the Sr. Director, Genospace Engineering.

What You'll Do (Responsibilities)

  • Design cross-domain architecture - define end-to-end architecture for complex systems that span data pipelines, application services, and AI/ML workloads, balancing scalability, reliability, security, and cost.
  • Lead data engineering at scale - design and deliver ingestion, transformation, storage, and governance for large volumes of genomic and clinical data, with strong data quality and lineage.
  • Build production software across the stack - architect and implement robust services from back-end data stores through APIs to front-end experiences, with a keen sense for making things fast and efficient.
  • Productionize AI/ML - design, develop, and deploy AI/ML and GenAI capabilities, and establish the MLOps foundations (training, evaluation, deployment, monitoring, and responsible-AI practices) that keep them dependable.
  • Set the engineering bar - establish and champion standards for code quality, testing, security, scalability, and regulatory compliance (e.g., HIPAA / PHI handling).
  • Drive technical strategy - shape multi-quarter technical roadmaps and make build/buy and platform decisions in partnership with engineering, product, and data-science leadership.
  • Multiply the team - mentor senior and junior engineers, lead design and code reviews, and grow technical talent and best practices across the organization.
  • Advance the state of the art - evaluate and introduce new technologies, frameworks, and practices where they create measurable improvement, and stay current with the evolving AI and data landscape.
  • Partner with stakeholders - work with clients, account management, and clinical stakeholders to translate ambiguous business needs into elegant, durable technical solutions - you enjoy coming up with solutions rather than being told what to build.
  • Other duties may be assigned as needed to meet company goals.


What We're Looking For (Requirements)

  • Degree or equivalent and typically requires 10+ years of relevant experience. Less years required if has relevant Master's or Doctorate qualifications.
  • 10+ years of software engineering experience, including a demonstrated track record of technical leadership on large, complex, distributed systems.
  • Bachelor's degree in Computer Science, Engineering, or a related field; advanced degree preferred.
  • Breadth across three disciplines - deep expertise in at least two of, and working fluency across all three of: data engineering, software engineering, and AI/ML engineering.
  • Proven ability to design and operate distributed systems and data-intensive applications at scale.
  • Proficiency in one or more modern languages (e.g., Python, Java, C#, Go, or TypeScript) and strong command of data technologies such as SQL and big-data or streaming frameworks.
  • Hands-on experience building and deploying production AI/ML systems using frameworks such as TensorFlow, PyTorch, or scikit-learn.
  • Strong software-engineering fundamentals: design patterns, object-oriented principles, automated testing, and CI/CD.
  • Excellent communication skills and the ability to influence and align engineering, product, and executive stakeholders without direct authority.


Additional Knowledge & Skills

  • Data engineering: pipeline orchestration, data modeling, warehouse / lakehouse architectures, and data quality, lineage, and governance.
  • AI engineering: model development, LLM / GenAI application patterns, MLOps, evaluation, and responsible and secure AI practices.
  • Cloud & DevOps: depth in AWS, Azure, or Google Cloud, with modern tooling - infrastructure-as-code, containers, Kubernetes, and observability.
  • Domain (a strong plus): healthcare, genomics, or life-sciences experience, and familiarity with regulated-data environments (HIPAA / PHI).
  • Technical leadership: a proven ability to mentor engineers, set technical vision, and lead through influence across teams.


We are proud to offer a competitive compensation package at McKesson as part of our Total Rewards. This is determined by several factors, including performance, experience and skills, equity, regular job market evaluations, and geographical markets. The pay range shown below is aligned with McKesson's pay philosophy, and pay will always be compliant with any applicable regulations. In addition to base pay, other compensation, such as an annual bonus or long-term incentive opportunities may be offered. For more information regarding benefits at McKesson, please click here.

Our Base Pay Range for this position

$149,600 - $249,400

McKesson has become aware of online recruiting-related scams in which individuals who are not affiliated with or authorized by McKesson are using McKesson's (or affiliated entities, like CoverMyMeds or RxCrossroads) name in fraudulent emails, job postings or social media messages. In light of these scams, please bear the following in mind:

McKesson Talent Advisors will never solicit money or credit card information in connection with a McKesson job application.

McKesson Talent Advisors do not communicate with candidates via online chatrooms or using email accounts such as Gmail or Hotmail. Note that McKesson does rely on a virtual assistant (Gia) for certain recruiting-related communications with candidates.

McKesson job postings are posted on our career site: careers.mckesson.com.

About McKesson

McKesson Corporation provides medicines, pharmaceutical supplies, information and care management products and services across the healthcare industry. The Company operates in two segments. The McKesson Distribution Solutions segment delivers ethical drugs, medical-surgical supplies and equipment and health and beauty care products throughout North America. This segment also provides specialty pharmaceutical solutions for biotech and pharmaceutical manufacturers, sells financial, operational and clinical solutions for pharmacies (retail, hospital, long-term care) and provides consulting, outsourcing and other services. The McKesson Technology Solutions segment delivers enterprise-wide clinical, patient care, financial, supply chain, strategic management and software solutions. In July 2011, the Company acquired Portico Systems from Safeguard Scientifics, Inc. On March 25, 2012, it acquired the independent banner and franchise businesses of Katz Group Canada Inc. McKesson Distribution Solutions delivers pharmaceuticals to retail pharmacies and institutional providers like hospitals and health systems. They operate pharmaceutical distribution centers across the country, serving customers in all 50 states. They also deliver a comprehensive offering of health care products, technology, equipment and related services to the alternate site market, including physician offices, surgery centers, long-term care facilities and home care businesses across the country. McKesson is currently the largest pharmaceutical distributor in North America. McKesson also operates McKesson Canada and has an equity holding in Nadro, a leading distributor in Mexico.

McKesson Careers

Join McKesson, a leading global healthcare company, and be part of a team that is redefining the future of healthcare. With a variety of job opportunities available, McKesson is the perfect place to advance your career, whether you're a seasoned professional or just starting out. Work You’ll Do At McKesson, we are committed to improving care in every setting—one product, one partner, one patient at a time. We’re seeking talented professionals to join our team and contribute to a culture of innovation, diversity, and leadership. Our employees are driven by a deep sense of purpose and a desire for continuous growth and improvement. Empower Your Future in Healthcare With positions ranging from internships to leadership roles, McKesson offers unparalleled employment opportunities to develop your skills and advance your career. Our commitment to diversity training ensures that all team members have the opportunity to thrive. Join a team where your skills will be honed, your professional growth will be supported, and where you can genuinely see the difference you make in the lives of patients around the world. Innovative Work Environment McKesson is at the forefront of healthcare innovation. Our team is constantly exploring new ways to improve patient outcomes and streamline care processes. This commitment to innovation is what sets us apart and what makes McKesson an exciting place to work. Career Development and Benefits McKesson believes in nurturing the potential of its employees through robust career development programs and comprehensive benefits designed to support your life and well-being. From leadership training to health and wellness benefits, we ensure our team members are equipped to meet their professional and personal goals. Explore Job Opportunities Whether you’re looking for an internship to kickstart your career, or a senior position to utilize your extensive experience, McKesson offers a range of opportunities. Explore our open positions and find where you can make a difference at McKesson. Stay Connected Join Our Team Search for open positions that match your skills and interests. We are looking for passionate, curious, and solution-driven team players who are ready to take the next step in their careers. Keep Up to Date Stay ahead with career tips, insider perspectives, and industry-leading insights you can put to use today—all from the people who work here. Networking and Professional Growth At McKesson, networking and professional growth are part of our everyday environment. We encourage our employees to connect, share, and learn from each other to foster personal and professional development. Job Alert Emails Personalize your subscription to receive job alerts, latest news, and insider tips tailored to your preferences. Discover the exciting and rewarding career opportunities that await you at McKesson. Join McKesson today and be part of a team that is dedicated to shaping the future of healthcare.
Learn more about McKesson
Size
58,000 employees
Market Cap
$53.7 billion
Industry
Net Income
-$4.1 billion
Founded
1833
5 Year Trend
+5.9%
Revenue
$237.6 billion
NASDAQ

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