WebMD

Principal Architect, AI-Native Applications

WebMD$150K — $200K *
Healthcare
5 - 7 years of experience
Job Overview by Ladders

Qualifications

  • 7+ years in software architecture or backend engineering with senior technical leadership experience.
  • Proven ability in architecting complex, distributed backend systems using microservices and event-driven patterns.
  • Hands-on experience with data platforms tailored for high-volume, high-dimensional AI workloads.
  • Experience building AI-native applications, particularly with LLM integration and retrieval-augmented generation.
  • Strong knowledge of cloud architecture (AWS, Azure, GCP) and operating in hybrid environments.
  • Ability to engage with hands-on coding while leading architectural strategies.
  • Understanding of healthcare compliance and security requirements, specifically HIPAA.

Responsibilities

  • Define and implement application architecture standards for teams across the organization.
  • Architect and design backend systems, focusing on microservices and data engineering.
  • Create high-performance data platforms suitable for AI tasks and large datasets.
  • Establish patterns for AI-native applications including advanced integration strategies.
  • Conduct thorough architecture reviews to ensure designs meet operational standards.
  • Set API and service standards to facilitate prototyping and production deployment.
  • Collaborate with cross-functional teams to align technical efforts with business goals.
  • Mentor senior engineers and enhance architectural understanding within the team.

Benefits

  • Health Insurance (medical, dental, and vision)
  • Paid Time Off (vacation, sick leave, flexible holidays)
  • 401(k) Retirement Plan with employer matching
  • Life and Disability Insurance
  • Employee Assistance Program (EAP)
  • Commuter and/or Transit Benefits (if applicable)
Full Job Description
Description

Position at WebMD

About the Role:

The Principal Architect, AI-Native Applications is the lead technical authority for how WebMD Ignite designs, builds, and scales modern applications in an AI-native environment. This role defines the architectural patterns, standards, and reference implementations that development teams across the organization build against, with a particular focus on backend systems, data-intensive services, and applications that embed large language models, retrieval-augmented generation, and agentic workflows. The Principal Architect operates as a hands-on individual contributor and technical leader, remaining close enough to the code to pair with senior engineers and validate design decisions directly. This is a senior, cross-cutting role that establishes a coherent application architecture practice where design decisions are currently made project by project.
Key Responsibilities:
  • Define and own the application architecture patterns, standards, and reference implementations that development teams build against across the organization.
  • Architect complex backend systems, including microservices architectures, APIs, streaming and event-driven protocols, and data engineering pipelines.
  • Design high-performance data platforms for AI workloads, including vector stores, graph databases, distributed caching, and semantic retrieval over million-record corpora.
  • Establish the patterns and guardrails for AI-native applications, including LLM integration, retrieval-augmented generation, multi-model orchestration, and agentic workflows.
  • Conduct architecture reviews and ensure solution designs meet scalability, performance, security, interoperability, and cost requirements across both cloud and on-premises environments.
  • Set standards for AI-ready APIs, data services, and application frameworks that enable rapid prototyping and production rollout of new capabilities.
  • Partner with engineering, product, data, and DevOps leaders to align technical direction with business outcomes and delivery timelines.
  • Ensure architectures meet the security, compliance, and privacy requirements of regulated healthcare environments, including HIPAA and the handling of protected health information (PHI).
  • Provide technical mentorship to senior engineers and raise the overall architecture fluency of the engineering organization.
Qualifications:
  • 7+ years of experience in software architecture, backend engineering, or data engineering, including senior or principal-level technical leadership.
  • Demonstrated experience architecting complex, distributed backend systems using microservices, APIs, and event-driven or streaming patterns.
  • Hands-on experience designing and operating data platforms for high-volume, high-dimensional workloads, including vector databases, graph databases, distributed caching, and semantic retrieval.
  • Practical experience building AI-native or AI-enabled applications, including LLM integration, retrieval-augmented generation, orchestration frameworks, and agentic systems.
  • Strong command of cloud architecture (AWS, Azure, or GCP) and experience operating across both cloud and on-premises environments.
  • Ability to remain hands-on in code while providing architecture-level leadership.
  • Working knowledge of the security, privacy, and compliance requirements of healthcare data environments, including HIPAA and PHI handling.
  • Excellent communication skills, with the ability to translate complex technical concepts for both engineering and business audiences.
Preferred Skills:
  • Experience in a healthcare, health IT, or other regulated data environment.
  • Experience operating within HITRUST, NIST, or similar compliance frameworks.
  • Familiarity with modern warehouse/lakehouse and high-performance analytical data platforms.
  • Experience defining developer tooling, standards, and AI-assisted software development workflows.
Compensation: $150,000 - $200,000
Bonus Eligible:

This position is also eligible for a discretionary company bonus, based upon business results.
Benefits:

Employees in this position are eligible to participate in the company sponsored benefit programs, including the following within the first 12 months of employment:
  • Health Insurance (medical, dental, and vision coverage)
  • Paid Time Off (including vacation, sick leave, and flexible holiday days)
  • 401(k) Retirement Plan with employer matching
  • Life and Disability Insurance
  • Employee Assistance Program (EAP)
  • Commuter and/or Transit Benefits (if applicable)

Eligibility for specific benefits may vary based on job classification, schedule (e.g., full-time vs. part-time), work location and length of employment.

About WebMD

WebMD is an American corporation known primarily as an online publisher of news and information pertaining to human health and well-being. The site includes information pertaining to drugs. It is one of the top healthcare websites by unique visitors.
Learn more about WebMD
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1,700 employees
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