Eli Lilly

Postdoctoral Scientist - Neuropsychiatry

Eli Lilly • $58K — $123K *
Boston, MA 02115In-Person
Pharmaceuticals & Biotech
Less than 5 years of experience
Today
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Job Overview by Ladders

Qualifications

  • PhD in Neuroscience, Cell Biology, Molecular Biology, or a related field.
  • Experience with human iPSC culture or neuronal culture techniques.
  • Proven track record of publications indicating scientific independence.
  • Legal authorization to work in the US on a full-time basis.
  • Interest in psychiatric diseases and translational neuroscience research.

Responsibilities

  • Develop human iPSC-derived tri- and quad-culture models for neuron-glia studies.
  • Utilize MEA electrophysiology and automated patch-clamp for assessing network dynamics.
  • Implement mRNA lipid nanoparticle delivery for gene perturbation in iPSC cultures.
  • Examine effects of psychiatric risk gene variants on astrocyte function.
  • Conduct single-cell RNA-Seq and perform pathway analysis for disease-associated genes.
  • Integrate various datasets to identify links between genetic changes and neuronal dysfunction.
  • Conduct rescue experiments to validate therapeutic strategies.

Benefits

  • Participation in a company-sponsored 401(k) plan.
  • Access to medical, dental, vision, and prescription drug benefits.
  • Flexible benefits including healthcare spending accounts.
  • Life insurance and death benefits.
  • Employee well-being programs including fitness benefits and assistance initiatives.
Full Job Description
Are you looking to make a significant difference by advancing our understanding of psychiatric diseases such as schizophrenia and major depressive disorder? If so, this might be the right role for you. We are seeking an ambitious postdoctoral scientist with strong research and communication skills to contribute to a high-visibility research program at the intersection of human iPSC biology, neuroscience, and functional genomics.

Your work will contribute to establishing a cutting-edge human iPSC-derived co-culture platform to study neuron-astrocyte interactions in psychiatric conditions - a powerful approach to uncovering disease mechanisms and identifying novel therapeutic targets. In this role, you will:
  • Develop and characterize human iPSC-derived tri- and quad-culture models containing excitatory neurons, inhibitory neurons, astrocytes, and potentially microglia to study neuron-glia interactions in psychiatry-relevant contexts.
  • Apply multielectrode array (MEA) electrophysiology and automated patch-clamp (autopatcher) to assess network dynamics and single-cell excitability in iPSC co-culture models.
  • Utilize mRNA lipid nanoparticle (LNP) delivery for transient gene overexpression and perturbation (including CRISPR knockout/interference) in iPSC cultures - a novel approach in this field.
  • Investigate functional consequences of psychiatric risk gene variants on astrocyte function and neuron-astrocyte signaling.
  • Perform single-cell or single-nucleus RNA-Seq from co-culture models and apply pathway analysis to identify disease-associated gene modules and hub genes.
  • Integrate multi-modal datasets (electrophysiological, morphological, transcriptomic) to establish mechanistic links between genetic perturbations and neuronal network dysfunction.
  • Design and execute rescue experiments using pharmacological and genetic strategies to validate therapeutic hypotheses.
  • Collaborate with cross-functional teams including computational biology, bioinformatics, medicinal chemistry, and external academic partners.
  • Present findings at major scientific conferences (e.g., Society for Neuroscience, ACNP) and publish in high-impact peer-reviewed journals as first author.
  • Maintain external awareness and learning to benefit the organization. Identify areas of key need to champion creative solutions.


Basic Qualifications
  • PhD in Neuroscience, Cell Biology, Molecular Biology, or a closely related field.
  • Demonstrated experience with at least one of the following: human iPSC culture and directed differentiation, primary neuronal culture, electrophysiology (patch-clamp or MEA), or neuron-glia biology.
  • Strong publication record demonstrating scientific productivity and independence.
  • Qualified applicants must be authorized to work in the United States on a full-time basis. Lilly will not provide support for or sponsor work authorization or visas for this role, including but not limited to F-1 CPT, F-1 OPT, F-1 STEM OPT, J-1, H-1B, TN, O-1, E-3, H-1B1, or L-1.

Additional Information
  • This position is not permanent and requires US citizenship or permanent resident status. It is for a fixed duration of two years with potential to extend to three years and for a maximum of up to four years. You will have opportunities to apply for full-time positions after your duration is complete.

Additional Skills/Preferences
  • Self-directed and highly motivated individual who wants to learn new techniques while continually pursuing research and publication goals.
  • Excellent communicator (oral and written) with presentation experience, along with a strong publication record.
  • Interest in psychiatric disease mechanisms and translational neuroscience research.
  • Experience with human iPSC culture, neural differentiation protocols, and co-culture system development.
  • Experienced with electrophysiology platforms including multielectrode array (MEA) and/or automated patch-clamp systems.
  • Experience with mRNA or lipid nanoparticle (LNP) delivery systems is a plus.
  • Familiarity with CRISPR-based gene editing tools (knockout, CRISPRi/a, base editing).
  • Proficiency in high-content imaging, immunofluorescence, and automated image analysis.
  • Experience with single-cell RNA-Seq data acquisition, bioinformatics analysis, and pathway enrichment tools.
  • Strong analytical skills and ability to integrate multi-modal datasets.


Actual compensation will depend on a candidate's education, experience, skills, and geographic location. The anticipated wage for this position is
$58,000 - $123,200

Full-time equivalent employees also will be eligible for a company bonus (depending, in part, on company and individual performance). In addition, Lilly offers a comprehensive benefit program to eligible employees, including eligibility to participate in a company-sponsored 401(k); pension; vacation benefits; eligibility for medical, dental, vision and prescription drug benefits; flexible benefits (e.g., healthcare and/or dependent day care flexible spending accounts); life insurance and death benefits; certain time off and leave of absence benefits; and well-being benefits (e.g., employee assistance program, fitness benefits, and employee clubs and activities).Lilly reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion and Lilly's compensation practices and guidelines will apply regarding the details of any promotion or transfer of Lilly employees.

#WeAreLilly

About Eli Lilly

ICOS Corporation is a biotechnology company that engages in the discovery, development, and commercialization of therapeutic products. It is engaged in the commercialization of treatments for unmet medical conditions, such as benign prostatic hyperplasia, hypertension, pulmonary arterial hypertension, cancer, and inflammatory diseases. It is the developer of a treatment known as Cialis (tadalafil), a product for the treatment of erectile dysfunction through its joint venture with Eli Lilly and Company in North America and Europe. It is also engaged in contract manufacturing services for third parties. It is in a strategic alliance with Solvay Pharmaceuticals, Inc. ICOS Corporation was established in 1989, based in Bothell, Washington. It is currently operated by Eli Lilly and Company.

Eli Lilly Careers

Joining Eli Lilly offers an unparalleled opportunity to become part of a leading global team dedicated to creating a healthier future. As a company revered for its commitment to innovation and leadership in the pharmaceutical industry, Eli Lilly is where your professional journey can flourish. Work You’ll Do At Eli Lilly, we are passionate about transforming patient care and advancing medical innovation. Our team at Eli Lilly is at the forefront of developing groundbreaking solutions in healthcare. By joining us, you will collaborate with some of the brightest minds in the industry, using cutting-edge technology to make real-world impacts. Lead with Innovation and Leadership Eli Lilly stands out in the marketplace by integrating deep industry expertise with robust research and development efforts. We are looking for professionals who are eager to drive change and lead the way in developing therapeutic breakthroughs. Explore Job Opportunities and Growth Eli Lilly offers a variety of career paths, including full-time positions and internships, across multiple functions such as research, marketing, IT, and sales. Whether you are a seasoned professional or a recent graduate, Eli Lilly provides an environment that promotes career growth and learning opportunities. Our commitment to diversity and leadership training ensures that every employee can achieve their potential. Be Part of Our Team Our team at Eli Lilly is committed to excellence and driven by a mission to improve lives. Employees enjoy a supportive culture that values collaboration, creativity, and diversity. We believe that a diverse workforce fosters innovation and helps us better connect with the communities we serve. Benefits and Culture Eli Lilly is dedicated to supporting our employees, offering competitive benefits, wellness programs, and comprehensive health care. Our culture is built on a foundation of respect, integrity, and quality, making Eli Lilly not just a great place to work, but a community to grow with. Networking and Professional Development Eli Lilly encourages continuous professional development and networking. With access to various training programs and mentorship opportunities, employees can enhance their skills and advance their careers. Our leadership is committed to nurturing talent through effective training and development strategies. Join Our Team Discover the exciting job opportunities at Eli Lilly by exploring open positions that match your skills and interests. We are continuously hiring and looking for individuals who are passionate, innovative, and ready to contribute to our mission of making life better for people around the globe. Stay Connected Keep up to date with the latest at Eli Lilly by following our careers blog. Gain insights from industry leaders and get tips on everything from crafting the perfect resume to preparing for your interview. Eli Lilly is not just a company—it's a place where you can make a difference. Explore the positions available and find out how your talents can help change the world. SEARCH ELI LILLY JOBS Stay ahead in your career with Eli Lilly, where innovation, leadership, and a commitment to diversity and growth lead the way to future advancements.
Learn more about Eli Lilly
Size
35,000 employees
Market Cap
$344.2 billion
Industry
Pharmaceuticals & Biotech
Net Income
$6.1 billion
Founded
1876
5 Year Trend
+5.9%
Revenue
$24.5 billion
NASDAQ
LLY
* Ladders Estimates

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