Eli Lilly and Company's Immunology organization is seeking a highly motivated Postdoctoral Research Fellow to lead a mechanistic research program comparing two clinically important T cell-redirecting immunotherapy platforms: bispecific T cell engagers (TCEs) and chimeric antigen receptor (CAR) T cell therapies, including transient mRNA-encoded CAR approaches. This is a unique opportunity to conduct hypothesis-driven, publication-caliber research at the interface of basic immunology and translational drug discovery, embedded within an active, industry-leading immunology discovery team. The postdoctoral fellow will design and execute a systematic, multi-aim research program using established internal reagents, cell lines, and assay platforms, with the goal of generating valuable mechanistic insights. In this role, you will: - Support immunology research project advancing understanding of T Cell biology in the context of T Cell Engagers and CAR T Cell Therapies - Work in close collaboration with immunology research, in vivo pharmacology and bioinformatics groups - Perform phenotypic and functional characterization of T cells using: - Primary human T and B cell isolation and co-culture - Multiparameter flow cytometry - Multiplex cytokine profiling (MSD) - Transcriptional profiling (NanoString; potential single-cell RNA sequencing) Basic Qualifications: - Ph.D. in Immunology, Cell Biology, Molecular Biology, or a related field (completed or near completion). - Strong foundational knowledge of T cell biology - Qualified applicants must be authorized to work in the United States on a full-time basis. Lilly will not provide support for or sponsor work authorization or visas for this role, including but not limited to F-1 CPT, F-1 OPT, F-1 STEM OPT, J-1, H-1B, TN, O-1, E-3, H-1B1, or L-1 Preferred Qualifications: - Direct research experience with T cell engagers (TCEs) and/or CAR T cell platforms, including cytotoxicity assays and mechanistic characterization. - Hands-on experience with primary human immune cell isolation and culture, multiparameter flow cytometry, and standard immunoassay techniques. - Experience with multiplex cytokine profiling (e.g., MSD), transcriptional profiling (e.g., NanoString or scRNA-seq), and/or lipid nanoparticle-mediated mRNA delivery. - Familiarity with regulatory T cell biology and immune subset dissection techniques. - Excellent communicator (oral and written) with presentation experience, along with a strong publication record. - Proficient in data analysis and reporting - Previously experienced with multidimensional flow cytometry. - Experience with scRNA-seq data acquisition and analysis Additional Information: - This position is not permanent. It is for a fixed duration of two years with potential to extend to 3 years and for maximum of up to 4 years. You will have opportunities to apply for full time positions after your duration is complete. Actual compensation will depend on a candidate's education, experience, skills, and geographic location. The anticipated wage for this position is $58,000 - $123,200 Full-time equivalent employees also will be eligible for a company bonus (depending, in part, on company and individual performance). In addition, Lilly offers a comprehensive benefit program to eligible employees, including eligibility to participate in a company-sponsored 401(k); pension; vacation benefits; eligibility for medical, dental, vision and prescription drug benefits; flexible benefits (e.g., healthcare and/or dependent day care flexible spending accounts); life insurance and death benefits; certain time off and leave of absence benefits; and well-being benefits (e.g., employee assistance program, fitness benefits, and employee clubs and activities).Lilly reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion and Lilly's compensation practices and guidelines will apply regarding the details of any promotion or transfer of Lilly employees.