Hands-on experience in oligonucleotide synthesis and purification.
Bachelor’s or Master’s degree in Organic Chemistry or related field.
Experience in RNAi therapeutics preferred.
Strong communication and interpersonal skills.
Highly motivated with problem-solving and organizational abilities.
Responsibilities
Collaborate across therapeutic areas to enhance drug discovery strategy.
Troubleshoot and operate lab equipment like oligo synthesizers and HPLC.
Perform literature reviews and develop nucleic acid chemistry plans.
Coordinate chemistry and biology data to advance oligonucleotide compounds.
Establish scaled-up synthesis methods for lead molecules.
Maintain high productivity to meet study timelines.
Benefits
Opportunity to work in a dynamic research environment.
Collaborative team culture across multiple therapeutic areas.
Development of cutting-edge oligonucleotide therapies.
Access to advanced lab equipment and technologies.
Support for professional growth and skill development.
Full Job Description
Responsibilities :
The candidate will work in an oligonucleotide therapeutic drug discovery research lab and interface across different therapeutic areas, including neuroscience, immunology and oncology, to help build a comprehensive therapeutic discovery strategy.
Good understanding and also troubleshooting experience in oligonucleotide synthesis, impurity profiling is a plus.
Collaborate with other scientists to maintain common lab equipment such as oligo synthesizers, HPLC and desalting units.
Perform literature reviews, propose, and execute nucleic acid chemistry plans, coordinate chemistry and biology data to support oligonucleotide compound progression.
Establish methods for scaled-up synthesis of lead molecules and coordinate material delivery for preclinical studies.
Maintaining a high level of productivity in the laboratory setting to meet the timelines for in vitro and in vivo studies.
Required Skills :
The candidate must have hands-on experience in oligonucleotide synthesis using automated oligo synthesizers, novel nucleic acid chemistry, oligonucleotide purification and characterization using HPLC and mass spectrometry.
The qualified individual will possess a BS/MS in Organic Chemistry or related discipline.
The pharmaceutical or biotechnology industry experience in research and development of RNAi therapeutics is preferred.
Good communication and interpersonal skills are essential and will be evaluated during the interview process.
The ideal candidate should be highly motivated and have strong problem-solving, analytical, communication and organizational skills.
Preferred Skills :
A good understanding of nucleic acid therapeutic modalities, modification chemistries, sequence selection, and mechanism of action is preferred. Relevant experience in oligonucleotide therapeutics, large molecule drug discovery, oligonucleotide delivery or bio-conjugation is desirable.
