What You Will Contribute To AltosJoin the Rosi Lab, part of the Discovery Sciences organization at Altos Labs Bay Area, as an integral part of our neuroscience research team. We are seeking a highly skilled and meticulous Research Associate or Research Specialist (I/II) with exceptional expertise in in vivo brain surgeries and animal behavior. In this pivotal role, you will drive critical surgical workflows and generate disease-relevant models to help uncover mechanisms of brain health and resilience. You will be directly contributing to our overarching mission of reversing disease and restoring cellular health.
Responsibilities- Advanced Surgical Interventions: Perform exceptionally precise cranial window surgeries in murine models to a consistently high standard. This includes the preparation of chronic glass windows, headplate/headbar implantations, and setups optimized for longitudinal imaging over weeks to months.
- Precision Stereotaxic Delivery: Execute highly accurate stereotaxic brain surgeries for the targeted intracranial delivery of AAV vectors, anatomical/vascular tracers, and other therapeutic agents, skillfully adapting to strain-related anatomical variations.
- End-to-End Surgical Management: Independently manage the complete surgical workflow, encompassing sterile pre-operative preparation, precise anesthetic management, the surgical procedure, and meticulous post-operative monitoring and care.
- Disease Modeling & Cohort Generation: Work across a range of neurodegenerative models, strategically managing timed cohort generation to align with critical disease-stage endpoints.
- Behavioral Assay Integration: Conduct and support complex animal behavior assays in tandem with surgical models to correlate in vivo findings with functional outcomes.
- Compliance & Data Integrity: Maintain rigorous and detailed surgical records, ensure strict adherence to all IACUC protocols, and uphold the highest standard of animal welfare at all times.
Who You AreThe level of the position will depend on the qualifications of the selected candidate.
Minimum Qualifications, Knowledge, Skill and Abilities- Education: Bachelor's or Master's degree in Neuroscience, Biology, Bioengineering, or a related scientific discipline.
- Experience: 5+ years of extensive, hands-on experience with stereotaxic and cranial window surgeries in rodent models within an academic or industry setting.
- Technical Proficiency: Demonstrated success with intracranial viral vector (AAV) delivery and longitudinal in vivo study designs.
- Subject Matter Expertise: Knowledge of neurodegenerative disease models (e.g., Alzheimer's, tauopathies).
- Professional Characteristics: Exceptional manual dexterity, high attention to detail, and the ability to work independently while collaborating effectively within a dynamic, fast-paced research team.
Preferred Qualifications, Knowledge, Skill and Abilities- Hands-on expertise with in vivo brain imaging with miniscope, awake head-fixed imaging paradigms, and behavioral habituation.
- Proficiency utilizing genetically encoded indicators, reporter lines, intravascular dyes, and neuronal tracers, as well as experience implanting complex devices like chronic cannulae, telemetry, and EEGs.
- Familiarity with advanced behavioral testing paradigms in rodents.
- Experience with tissue processing, sectioning, and immunohistochemistry downstream of surgical interventions.
The salary range for Redwood City:
- Research Associate: $
- Senior Research Associate: $
- Research Specialist: $
Exact compensation may vary based on skills, experience, and location.
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