Job DescriptionThe position will support a Neuroscience Biomarkers client team that is responsible for immunoassay-based methods to identify and quantify biomarkers associated with neurodegenerative diseases, including Alzheimer's Disease, Parkinson's Disease, and Amyotrophic Lateral Sclerosis. We are looking for a motivated scientist eager to gain hands-on experience in immunoassay workflows applied to serum, plasma, CSF, sample lysate and tissue biomarker studies, and to grow their technical skills in a collaborative, fast-moving research environment.
Job Responsibilities:- Analyses as part of the development and validation of novel immunoassay-based biomarker methods, as well as applications of these methods for clinical trials in neurodegenerative diseases, including Alzheimer's, Parkinson's, ALS, and rare brain disorders.
- Work with project team leads and other associates to perform experiments to support both the preclinical and clinical characterization and evaluation of therapeutic molecules through biomarker assay development.
- Assist with the planning and execution of immunoassay method developments, method optimization and validation, as well as sample analyses from different preclinical samples sets and clinical cohorts.
- Work directly on-site with methods in the laboratory, and with summarizing and reporting method status of results for internal partners.
- Implement assay validation procedures to deliver high-performance biomarker assays for preclinical and clinical sample analyses.
QualificationsBasic Minimum Qualifications:- B.S. in Biology, Chemistry, Biochemistry, or related life sciences field with at least 3 years of relevant industry experience utilizing ELISA and MSD.
- Strong understanding of the principles for immunoassays (e.g. antibodies and other ligand-based molecules, assay design), protein biomarker quantification, and assay validation.
- Hands-on experience in protein biomarker applications (e.g. clinical diagnostics, clinical trials, or preclinical sample analysis).
- Experience working with human or animal specimens (tissue and biofluids such as plasma, serum, and CSF) under BSL-2 or equivalent safety conditions.
Preferred Qualifications:- Experience with clinical sample analysis using immunoassay methods.
- Additional qualitative (e.g. electrophoresis techniques, Western blot) and quantitative (e.g. Ella, Simoa, NULISA, SpearBio) immunoassay-based analyses.
- Experience with Good Laboratory Practices (GLP), Clinical Laboratory Standards Institute (CLSI), and/or Clinical Laboratory Improvement Amendments (CLIA) validation standards.
- Authorization to work in the United States indefinitely without restriction or sponsorship.
Additional InformationThe position is
full-time, Monday-Friday, 8am-5pm with overtime as needed. Candidates living within a commutable distance of
Boston, MA are encouraged to apply.
Excellent full-time benefits include:- Comprehensive medical coverage, dental, and vision options
- Life and disability insurance
- 401(k) with company match
- Paid vacation and holidays
- Eligibility for yearly goal-based bonus & merit-based increases
- Compensation: $36.00-$41.00 per hour based on education and related experience.
