Preventive Medicine is a venture-backed biotech startup developing next-generation reproductive-genetics platforms to eliminate severe genetic disease before birth.
As one of the
first scientific hires, you will help define our technical roadmap, build our R&D culture from the ground up, and influence the long-term direction of the company. We are seeking an entrepreneurial
Scientist to design, build, and evaluate advanced
adenine & cytosine base editors (ABE, CBE) and RT editors. Partnering directly with the co-founders, you will take new editor concepts from the bench to IND-enabling studies while laying the foundation of our research organization.
Key Responsibilities - Establish the editor-engineering pipeline - Optimize ABE/CBE/RT-editing architectures for potency, specificity, and manufacturability
- High-throughput cloning & screening workflows (automated assembly, pooled libraries, functional reporters) and streamline data capture
- Develop quantitative assays for on- and off-target analysis using cutting-edge sequencing and bioinformatics platforms.
- Drive preclinical translation in relevant cell models and preclinical species
- Recruit, mentor, and lead a small team of research associates and scientists;
- Communicate program progress through protocols, data packages, and presentations to investors, advisors, and regulatory consultants.
RequirementsMinimum Qualifications - 5+ years hands-on experience engineering CRISPR base or prime editors in mammalian systems - demonstrated impact matters more than formal credentials.
- Proficiency with NGS library preparation & analysis (e.g., CRISPResso2, CRISPR-RGEN Tools) and basic Python/R scripting for data processing.
- Proven track record of leading complex projects and publishing or patenting influential work.
- Strong work ethic, scientific rigor, and high integrity.
Preferred qualifications - Familiarity with regulatory standards and assays relevant to gene-editing therapeutics
- Experience generating and using RNPs and mRNA for gene editing, including delivery via electroporation or nanoparticles.
- Prior startup or small-team experience in fast-moving environments.
- Comfort with automation (liquid handlers, LIMS) and/or single-cell genotyping/transcriptomics.
Benefits - Competitive salary plus meaningful equity-share in the company's upside.
- Comprehensive health, dental, and vision coverage.
- 401(k) with company match.
