Job Function:
Discovery & Pre-Clinical/Clinical Development
Job Sub Function:
Biotherapeutics R&D
Job Category:
Scientific/Technology
All Job Posting Locations:
Leiden, Netherlands, Spring House, Pennsylvania, United States of America
Job Description:
We are searching for the best talent for an
Experienced Scientist, In-vivo CAR-T, to be based on-site in Spring House, PA or Leiden, Netherlands.
Purpose:
The Experienced Scientist will support the formulation development, optimization, and scale-up of lentiviral vector (LVV) drug product formulation early to late-stage development. The role combines hands-on laboratory work with strong cross-functional collaboration to ensure robust, scalable, and GMP-ready processes.
Key Responsibilities:
Formulation development and optimization of viral vectors e.g., LVV drug product across early and late development stages
Perform hands-on laboratory work including formulation design, optimization, and characterization
Analyze and interpret data to support formulation development, optimization, and decision-making
Support formulation robustness activities
Contribute to scale-up and manufacturing readiness, including support of technology transfer to internal sites or CMOs
Collaborate cross-functionally with Analytical Development, Statistical, API, MSAT, Quality, Manufacturing, and Regulatory teams to ensure alignment on formulation strategy and execution of viral vectors
Document experimental work and results in accordance with GxP and data integrity requirements
Participate in troubleshooting activities and continuous process improvement initiatives
Qualifications:
Required:
B.S. or M.S. with 2-4 years of experience in an appropriate scientific discipline (Life Sciences or Chemical Engineering) is required
Relevant experience in formulation development of viral vectors and/or advance therapies
Strong hands-on laboratory experience in drug product development of viral vector development and statistics
Understanding of process scale-up, technology transfer, and GxP principles
Strong scientific problem-solving and data interpretation skills
Hands-on, proactive, and detail-oriented approach
Ability to work effectively in a cross-functional, matrixed environment
Clear and concise communication skills (written and verbal)
Ability to manage multiple priorities in a dynamic development environment
Preferred:
Experience with viral vector platforms, LVV in particular, and/or advanced therapies
Familiarity with formulation implementation for both early and late-stage development, process validation (e.g., LCPV) and manufacturing support
Exposure to both early and late-stage development requirements or commercial readiness activities
Required Skills:
Preferred Skills:
Analytical Reasoning, Biochemistry, Chemistry, Manufacturing, and Control (CMC), Coaching, Collaboration, Conducting Experiments, Data Quality, Drug Discovery Development, Molecular Diagnostics, Patent Applications, Pharmacogenetics, Report Writing, Research Documents, Scientific Research, Technologically Savvy, Written Expression
