Position SummaryThe Executive Director, Clinical Operations serves as the operational deputy and strategic partner to the VP, Clinical Operations. This high-impact executive role provides integrated leadership across the entire clinical operations ecosystem. You will translate high-level clinical strategy into seamless portfolio delivery, scalable organizational capability, and robust global execution. As a systems-builder and visionary leader, you will run today's global clinical portfolio with operational excellence while simultaneously building the capabilities required for tomorrow's late-stage development and commercialization.
Location: Global (US / Germany; Remote)
Reports To: Vice President, Clinical Operations
Salary Range: $270,000 to $300,000
Basic Qualifications:- Bachelor's degree in a scientific, nursing, or business discipline required;
- 15+ years of clinical research experience within a biotech, pharmaceutical, or major CRO environment, including 7+ years in a senior, multi-functional leadership capacity.
Preferred Qualifications:- Advanced degree (MD, PhD, PharmD, MS, or MBA) preferred.
- Direct operational experience managing Cell Therapy, Immuno-Oncology, or advanced therapeutic modality trials is a strong plus.
- Directly manage and inspire a geographically dispersed, multicultural clinical operations teams, with specific focus on harmonizing workflows between US and European (Germany) team members. A natural "systems builder" who thrives on creating infrastructure, optimizing workflows, and designing scalable processes. Demonstrated track record of leading multiple dimensions of clinical operations (e.g., trial management, data/systems, sample logistics, site monitoring).
- Extensive experience leading complex, global clinical trials across North America and Europe (experience with US/Germany structures is highly desirable). Deep experience navigating clinical operations in Oncology is required.
- Proven experience driving Phase III registrational trials, global regulatory filings (BLA/NDA/MAA submissions), and preparing operations for commercialization.
- Demonstrated experience leading Clinical Operations within a biopharmaceutical organization with strong understanding of internal clinical operations, trial execution and regulatory requirements.
- Sophisticated experience managing large-scale CRO partnerships and vendor governance committees.
- Strong communication and influencing skills, with the clear capability
Key Responsibilities1. Integrated Clinical Operations Leadership- Operational Deputy: Lead day-to-day operations of the global Clinical Operations organization on behalf of the VP; serve as primary delegate and decision-maker within established authority matrices.
- Functional Integration: Align functional teams to ensure Trial/Asset Operations, Site Operations, Biosample Operations, and Clinical Systems function as one unified, high-performing ecosystem.
- Strategic Alignment: Bridge the gap between corporate development milestones and operational realities, aligning all sub-functions toward shared portfolio timelines.
2. Portfolio Execution & Operational Oversight- Portfolio-Wide Visibility: Maintain an aggregated, holistic view across the entire clinical portfolio to proactively manage cross-program dependencies, critical paths, and resource constraints.
- Risk Mitigation: Establish early-warning frameworks to identify, escalate, and mitigate execution issues, protocol deviations, and trial bottlenecks.
- Leadership Coaching: influence and mentor clinical operations leads and asset directors on delivery strategy while ensuring accountability.
3. People, Talent & Organizational Leadership- Talent Development: Directly lead, mentor, and elevate the senior clinical operations leadership team; design robust succession plans and career pathways.
- Global Synchronization: Cultivate a unified, high-performing culture across the geographically dispersed US and Germany organizational footprints.
- Performance Architecture: Drive rigorous performance calibration, talent acquisition, strategic workforce planning, and organizational capability mapping.
4. Resource, Budget & Vendor Management- Operational Machinery: Own the infrastructure supporting portfolio capacity planning, headcount forecasting, and strategic resource deployment.
- Fiscal Stewardship: Oversee budget planning, accrual tracking, and financial forecasting; present highly accurate, data-driven operational intelligence to support the VP's strategic investment decisions.
- Vendor Governance: Partner with the Clinical Outsourcing group to manage CRO/vendor selection, performance metrics (SLA/KPI tracking), and governance frameworks.
- Sourcing Strategy: Drive rigorous analysis and provide actionable recommendations on insourcing vs. outsourcing strategies (FSP vs. full-service models).
5. Operational Excellence, Systems & Quality- Scalable Infrastructure: Champion continuous improvement initiatives, business process optimization, and structural scalability across all clinical workflows.
- Quality & GxP Compliance: Ensure strict adherence to ICH-GCP, FDA/EMA regulations, and global Standard Operating Procedures (SOPs).
- Inspection Readiness: Lead proactive inspection readiness frameworks, internal quality audits, and harmonized global data standards.
- Analytics & Metrics: Implement and monitor predictive operational metrics, KPIs, and executive dashboards to measure organizational efficiency.
6. Transformation & Future Readiness- Organizational Evolution: Co-architect and execute the future-state operating model as the pipeline transitions from early-stage to late-stage global development and commercialization.
- Change Management: Lead enterprise-wide change management, capability integration, and digital/systems evolution (e.g., CTMS, eTMF, decentralized trial technologies).
- Systems Problem-Solving: Design and deploy structural, repeatable organizational systems that eliminate recurring operational friction points.
What do we offer? At Immatics, we believe in investing in our team's health, safety and well-being. Here's what you can expect if you join Immatics
Comprehensive Benefits:
- Competitive rates for Health, Dental, and Vision Insurance
- PTO Accrued bi-weekly, with up to 80 hours available to borrow and a maximum accrued balance of 240 hours.
- 12 company paid holidays
- 10 days of sick time
- 100% employer-paid life insurance up to at 1x annual salary, up to one hundred thousand dollars
- 100% employer-paid short- and long-Term disability coverage
- 401(k) with immediate eligibility and company match...
- The company will match 100% of your contributions up to 3% of your base salary for the first two years of employment, 4% for years 2-3 of employment, and up to 5% of your salary from the fourth year onward of continued employment.
- Partially paid parental leave for eligible employees.
- Additional voluntary employee-paid benefits and services, including accident, hospital indemnity, and critical illness insurance, as well as identity theft protection and pet insurance.
