Position Summary:

The Director, Real-World Evidence (RWE) Scientist designs, executes, and delivers real-world studies within the HEOR/RWE function, with a primary focus on the atumelnant program — congenital adrenal hyperplasia (CAH), adult and pediatric, and Cushing's disease — through launch and into lifecycle management. Reporting to the Senior Director, Head of the RWE Center of Excellence, the Director owns Crinetics' CAH real-world data assets and leads the execution of the full range of observational studies — burden of illness, natural history, patient journey, treatment patterns, drug utilization, external control arms, and comparative effectiveness — using large healthcare databases (claims, EHRs, registries, linked datasets) and primary RWD collection. Working from evidence priorities defined by the HEOR/RWE Therapeutic Area (TA) Leads and direction from the RWE COE Head, the Director ensures continuity of atumelnant RWE through launch and produces rigorous, timely, decision-ready real-world evidence. The Director leads external analysts and study vendors, providing strategic oversight, mentoring, and quality assurance while maintaining the ability to engage deeply with analytics and study design.

Essential Job Functions and Responsibilities:

These may include but are not limited to:

• Design and execute real-world studies for the atumelnant program (CAH adult, CAH pediatric, Cushing's disease), including burden of illness, natural history, patient journey, treatment patterns, drug utilization, external control arms, and comparative effectiveness.
• Own and steward Crinetics' CAH real-world data assets—ensuring continuity, documentation, and reusability of cohorts, code lists, and analytic datasets.
• Lead analyses using large healthcare databases (insurance claims, EHRs, registries, linked datasets) and primary RWD collection (chart reviews, surveys).
• Develop study protocols, statistical analysis plans, and feasibility assessments; perform database selection and confirm that patient counts and study variables exist in available data.
• Ensure continuity of atumelnant RWE through launch, maintaining institutional knowledge of CAH RWE assets and program evidence needs.
• Translate evidence priorities set by HEOR/RWE TA Leads, under direction from the RWE COE Head, into executable analyses tied to launch and lifecycle milestones.
• Apply rigorous epidemiologic and outcomes-research methods, including appropriate causal-inference and bias-control techniques for observational data.
• Lead and mentor external analysts supporting in-house RWE analytics projects—scoping the work, directing analyses, and reviewing deliverables for methodological quality.
• Oversee RWE study vendors when analyses are outsourced—managing CRO/data-vendor execution against scope, timelines, budget, and deliverable quality.
• Contribute RWE outputs to integrated evidence plans, value dossiers, and HTA submissions in partnership with TA Leads and cross-functional stakeholders.
• Collaborate with the RWE Center of Excellence, Modeling & Simulation, Biometrics, and external data and analytics partners on study design and execution.
• Prepare manuscripts, abstracts, and congress presentations communicating RWE findings.
• Ensure compliance with corporate policies and US healthcare laws and regulations governing real-world data use.
• Other duties as assigned.

Education and Experience:

Required:

• Advanced degree in epidemiology, biostatistics, health services research, health economics, or related discipline (PhD, MD, PharmD, MPH, MSc).
• Minimum of 10 years of relevant pharmaceutical, biotech, or HEOR consulting experience executing observational research.
• Proven experience leading and developing teams, including external analysts or vendor partners.
• Equivalent combination of education and applicable job experience may be considered.
• Demonstrated expertise designing and executing observational studies using large real-world datasets (claims, EHR, registries).
• Strong working knowledge of real-world data programming and analytics (R preferred; SQL, SAS, or Python also valued), with the ability to guide and review analyses.
• Knowledge of epidemiologic and outcomes-research methodologies, including causal-inference and bias-control techniques for observational data.
• Experience with feasibility assessment, database selection, and study-design strategies to address real-world data limitations.
• Experience overseeing external analysts and/or CRO/data vendors, including scoping, oversight, budget management, and quality review of deliverables.
• Working knowledge of regulatory and HTA evidence expectations for RWE (FDA RWE Framework, ISPOR/ISPE good-practice guidance).
• Strong written and verbal communication skills, including scientific publication and presentation.
• Ability to collaborate effectively across functions and with external data partners.
• Ensure compliance with corporate policies and procedures, as well as US healthcare laws and regulations.
• Flexible, adaptable, and able to operate effectively in ambiguity; detail-oriented with strong execution discipline.

Preferred:

• Experience in rare or specialty endocrine, or other niche-population therapeutic areas.
• Familiarity with CAH, Cushing's disease, or related endocrine conditions.
• Experience with external control arms and target trial emulation.
• Familiarity with AI/ML-enabled phenotyping or modern RWE analytics platforms.

Physical Demands and Work Environment:

Physical Activities: On a continuous basis, sit at desk for a long period of time; intermittently answer telephone and write or use a keyboard to communicate through written means. Some walking and lifting up to 25 lbs. may be required. The noise level in the work environment is typically low to moderate. The physical demands described above are representative of those that must be met by an employee to successfully perform the essential functions and responsibilities of this job. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions and responsibilities.

Laboratory Activities (if applicable): Biology and chemical laboratory environment experience needed. Environmental health and safety requirements also apply.

Travel:

You may be required to travel for up to 5% of your time.

The Anticipated Base Salary Range: 

In addition to your base pay, our total rewards program consists of a discretionary annual target bonus, stock options, ESPP, and 401k match. We also provide top-notch health insurance plans for employees (and their families) to include medical, dental, vision and basic life insurance, 20 days of PTO, 10 paid holidays, and a winter company shutdown.

The final salary offered to a successful candidate will be dependent on several factors that may include but are not limited to the type and length of experience and education. Crinetics Pharmaceuticals is a multi-state employer, and this salary range may not reflect positions that work in other states. Your recruiter can share more about the specific salary range during the hiring process.

Salary Range

In addition to your base pay, our total rewards program consists of a discretionary annual target bonus, stock options, ESPP, and 401k match. We also provide top-notch health insurance plans for employees (and their families) to include medical, dental, vision and basic life insurance, 20 days of PTO, 10 paid holidays, and a winter company shutdown.