AstraZeneca

Director, Bacterial Vaccine Discovery

AstraZeneca$172K — $258K *
Pharmaceuticals & Biotech
8 - 10 years of experience
Job Overview by Ladders

Qualifications

  • PhD in microbiology, immunology, molecular biology, biochemistry, or related discipline with 8+ years of industry experience.
  • Proven leadership experience managing a team of junior scientists.
  • Strong track record in bacterial vaccine research and/or bacterial pathogenesis.
  • Experience in characterizing immune responses and protective efficacy of vaccine antigens in small animal models.
  • Familiarity with functional immunological assays used to measure vaccine-elicited responses.
  • Cross-functional collaboration experience in biotech or pharmaceutical research and development.
  • Proven ability to manage budgets for research programs and external partnerships.

Responsibilities

  • Lead a team of scientists in discovering and characterizing candidate vaccine antigens.
  • Serve as subject matter expert and lead for multiple programs, presenting strategy to senior leaders.
  • Present research findings at scientific conferences.
  • Partner with Translational Sciences to develop assays for clinical trial immune response characterization.
  • Oversee partnerships with academic institutions and biotech collaborators.
  • Evaluate external science and partnering opportunities to expand the vaccine pipeline.
  • Engage with intellectual property attorneys to refine IP strategy for early-stage programs.
  • Build relationships with senior leaders across various research functions for alignment.
  • Communicate project results, risks, and uncertainties clearly.
  • Define training and development opportunities for junior colleagues.

Benefits

  • Paid vacation and holidays
  • Paid leaves
  • Health benefits including medical, dental, and vision coverage
  • Qualified retirement program (401(k) plan)
  • Short-term incentive bonus opportunity
  • Eligibility to participate in equity-based long-term incentive programs
Full Job Description
The Director of Bacterial Vaccine Discovery in Early Infectious Disease leads efforts to discover and develop bacterial vaccines, including carbohydrate conjugate, mRNA, and protein-based approaches. The individual will lead a team of scientists in discovering and characterizing novel bacterial vaccines to build and advance the portfolio. The team will collaborate across groups within Bacterial Vaccines to identify effective vaccine candidates and fully characterize their immunogenicity and efficacy in preclinical disease models. The role also requires influencing senior internal stakeholders in Research, Bioprocess Development, and Regulatory Affairs, as well as managing external academic collaborations and contract research organizations to deliver the early vaccine portfolio.

Accountabilities

  • Lead a team of scientists to discover and characterize candidate vaccine antigens, delivering robust in vitro and in vivo research packages that support pipeline progression and regulatory interactions.


  • Serve as subject matter expert and research lead for multiple programs, presenting strategy and data to senior leaders at governance meetings.


  • Present key findings and research progress at top-tier scientific conferences.


  • Partner with Early Vaccines and Immune Therapies Translational Sciences to develop and transfer assays for characterizing immune responses in future clinical trials.


  • Oversee and maintain accountability for partnerships with third parties, including academic institutions and biotech collaborators.


  • Evaluate external science and partnering opportunities in collaboration with Business Development and the extended scientific team to expand the bacterial vaccine pipeline.


  • Engage regularly with intellectual property attorneys to define and refine IP strategy for early-stage programs.


  • Build and foster effective relationships with senior leaders across Research, Biochemistry, Bioinformatics, Clinical and Translational Medicine, and Global Project Teams to ensure cross-functional alignment.


  • Ensure clear and objective communication of results, associated risks, uncertainties, and limitations across all projects and teams within the function.


  • Define training and development opportunities for junior colleagues in line with best practices and scientific principles.


Qualifications

  • PhD in microbiology, immunology, molecular biology, biochemistry, or a related discipline, with 8+ years of industry experience.


  • Proven leadership experience managing a team of junior scientists (PhD and non-PhD level).


  • Strong track record in bacterial vaccine research and/or bacterial pathogenesis.


  • Demonstrated experience leading efforts to characterize immune responses and protective efficacy of vaccine antigens in small animal disease models.


  • Familiarity with functional immunological assays, such as opsonophagocytic killing assays and serum bactericidal assays, used to measure vaccine-elicited immune responses.


  • Cross-functional collaboration experience, successfully delivering research and development programs in a biotech or pharmaceutical setting.


  • Experience supporting or leading interdisciplinary vaccine discovery or development programs from early research through candidate selection.


  • Proven ability to develop and manage budgets for research programs and external partnerships.


  • Excellent communication skills, both written and verbal, with strong business analysis and consultancy capabilities.


The annual base pay for this position ranges from $172,466.40 - $258,699.60. Hourly and salaried non-exempt employees will also be paid overtime pay when working qualifying overtime hours. Base pay offered may vary depending on multiple individualized factors, including market location, job-related knowledge, skills, and experience. In addition, our positions offer a short-term incentive bonus opportunity; eligibility to participate in our equity-based long-term incentive program (salaried roles), to receive a retirement contribution (hourly roles), and commission payment eligibility (sales roles). Benefits offered included a qualified retirement program [401(k) plan]; paid vacation and holidays; paid leaves; and, health benefits including medical, prescription drug, dental, and vision coverage in accordance with the terms and conditions of the applicable plans. Additional details of participation in these benefit plans will be provided if an employee receives an offer of employment. If hired, employee will be in an "at-will position" and the Company reserves the right to modify base pay (as well as any other discretionary payment or compensation program) at any time, including for reasons related to individual performance, Company or individual department/team performance, and market factors.

Date Posted
22-Jun-2026

Closing Date
05-Jul-2026

About AstraZeneca

AstraZeneca is a British-Swedish multinational pharmaceutical company that specializes in the research, development, and manufacturing of prescription drugs. The company was formed in 1999 through the merger of Astra AB and Zeneca Group plc. AstraZeneca's products are used to treat a wide range of medical conditions, including cancer, cardiovascular disease, respiratory disease, and diabetes. The company has operations in over 100 countries and employs more than 76,000 people worldwide. AstraZeneca is committed to developing innovative medicines that improve the health and well-being of people around the world.
Learn more about AstraZeneca
Size
83,100 employees
Market Cap
$211.5 billion
Industry
Net Income
$3.1 billion
Founded
1999
5 Year Trend
+10.2%
Revenue
$26.6 billion
NASDAQ

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