Jefferies Financial Group

Data Scientist / Biostatistician

Jefferies Financial Group$135K — $165K *
Pharmaceuticals & Biotech
Less than 5 years of experience
Job Overview by Ladders

Qualifications

  • PhD, MD, or master's degree in relevant fields preferred
  • Strong Python or R programming skills
  • Proven experience in machine-learning and AI model development
  • Deep knowledge of clinical-trial design and statistical methodologies
  • Ability to simplify scientific and analytical concepts for diverse audiences
  • A keen interest in the biotech and pharma investment landscape
  • Equity research experience is a plus but not essential.

Responsibilities

  • Develop AI and statistical models for predicting clinical trial outcomes
  • Assess trial designs, endpoints, patient populations, and safety data
  • Utilize generative AI and NLP for comprehensive research analysis
  • Create tools for monitoring clinical pipelines and emerging risks
  • Translate model findings into actionable investment insights
  • Collaborate with analysts on forecasts and valuations
  • Ensure reliability of models by mitigating biases and errors.

Benefits

  • Opportunities for professional development and continuing education
  • Work in a cutting-edge, technology-driven environment
  • Collaborate with experienced professionals in biotech and finance
  • Potential for career progression within the company
  • Flexible work arrangements may be available
Full Job Description
Job Description

AI-Driven Biotech & Pharma Equity Research

We are seeking a Data Scientist / Biostatistician to join our biotech and pharmaceutical equity research team. The role will focus on building proprietary AI, machine-learning, and statistical models to predict clinical-trial outcomes and generate differentiated investment insights.

Responsibilities
  • Build AI and statistical models to predict clinical-trial results, probability of success, regulatory outcomes, and commercial potential.
  • Analyze trial design, endpoints, powering, patient populations, treatment effects, safety, and subgroup data.
  • Use generative AI, LLMs, and natural-language processing to analyze scientific publications, regulatory documents, trial registries, company disclosures, and earnings transcripts.
  • Create automated tools to track pipelines, clinical catalysts, competitive programs, and emerging risks.
  • Convert model outputs and clinical data into clear investment conclusions.
  • Work with research analysts on company forecasts, pipeline valuations, and published research.
  • Validate models and control for bias, overfitting, data leakage, and AI hallucinations.

Qualifications
  • PhD, MD, or master's degree preferred in biostatistics, statistics, data science, artificial intelligence, epidemiology, bioinformatics, computational biology, medicine, or a related field.
  • Strong Python or R skills.
  • Experience building machine-learning, predictive, or generative-AI models.
  • Strong knowledge of clinical-trial design and statistical analysis.
  • Ability to explain complex scientific and quantitative findings clearly.
  • Interest in biotechnology, drug development, investing, and financial markets.
  • Equity-research experience is helpful but not required.

Primary Location Full Time Salary Range of $135,000 - $165,000.

About Jefferies Financial Group

Jefferies Financial Group Inc. is a diversified financial services company that operates in investment banking, capital markets, asset management, and direct investing. The company was founded in 1962 and is headquartered in New York City. Jefferies Financial Group has operations in over 30 countries and employs over 4,000 people. The company's businesses include Jefferies, a global investment bank; Leucadia Asset Management, an asset management firm; and Berkadia, a commercial real estate company. Jefferies Financial Group is publicly traded on the New York Stock Exchange under the ticker symbol JEF.
Learn more about Jefferies Financial Group
Size
4,400 employees
Market Cap
$8 billion
Industry
Net Income
$775.2 million
5 Year Trend
-9.8%
Revenue
$6.7 billion

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