Overview:
Business Title: Chemist
IIIPosition Title:
Analyst IIIDivision:
Consumer Products ServicesEntity:
Consumer Products Services/ATLLocation:
Boston, MAReports to:
ManagerFLSA:
Non-exemptHours Worked:Typically,
Monday through Friday, forty-hours per week. However, must be flexible to meet the needs of the department and complete other projects as assigned.
Position Summary:
The
Analyst III will be responsible for analytical method development as well as maintaining and troubleshooting analytical instrumentations including but not limited to UPLC and LC-MS systems.
Duties and Responsibilities:
It is everyone's responsibility to live out our Values and Absolutes by Shaping a World of Trust while ensuring responsible progress.- Design and execute experiments related to sample preparation, quality control method development, and method condition screening, ensuring methods are scientifically sound, reproducible, and aligned with project or client objectives.
- Develop, adapt, and improve laboratory protocols, including but not limited to sample preparation, mobile phase preparation, sample quality control, chemical stability, and accelerated stability evaluation, to support consistent and reliable qualification and quantitation of target analytes.
- Perform complex mobile phase and sample preparations in support of analytical method development and non-routine laboratory activities.
- Troubleshoot and perform basic preventive maintenance on analytical instrumentation including Agilent Infinity LC systems, single quadrupole mass spectrometers, preparative HPLC, Thermo Vanquish UHPLC and Exploris series mass spectrometers.
- Work closely with members of the chemistry and bioconjugation teams to understand characterization needs/gaps and provide technical solutions to resolve complex molecular characterization challenges.
- Independently execute assigned responsibilities including Corrective and Preventive Actions (CAPA), system suitability testing (SST), and Analytical Quality Management (AQM), and refinement of quality control methods.
- Engage in technical discussions with project leaders to propose alternative approaches, investigate new methodologies and contribute to problem solving strategies.
- Independently operate work related software, including instrument specific software for capturing and analyzing data, Microsoft Office, LIMS, and electronic laboratory notebooks.
- Detailed record keeping of daily experiments in ELNs.
- Comply with clients and company management systems in accordance with appropriate regulatory agencies.
- Follow guidelines set forth by clients and in the company Quality, Health, Safety and Environmental policies and procedures.
- Perform other essential tasks, projects, and responsibilities as required.
- Other duties as defined by manager, department needs and workload.
Skills & Proficiencies:
- Experience in developing new chromatographic methods (UPLC and LC-MS).
- High performance liquid chromatography (HPLC)/mass spectrometry (MS)/LC-MS familiarity is required.
- Prior experience with ion pair reverse phase liquid chromatography is a plus.
- Experience with Agilent and Thermo UPLC and LC-MS instrumentation is a plus.
- Strong analytical thinking skills, demonstrating strategic and creative problem-solving skills and applying them to solve critical analytical characterization challenges.
- Strong interpersonal and communication skills. Proven record to collaborate and network across a wide variety of functions and work effectively with internal and external partners.
- Prior experience with analytical characterization of oligonucleotide and/or antibody conjugate is a plus.
- Experience with enzymatic digestion of antibody or protein prior to mass spectrometry-based characterization is a plus.
- Proficiency with mass spectrometry data processing and interpretation is a plus.
- Excellent organizational skills with the ability to work in a fast-paced team environment, meet deadlines, maintain detailed documentation, and prioritize work on multiple projects.
- Strong written and oral communication skills including the ability to communicate effectively in a group setting with colleagues and clients.
- Multitasking, ability to organize and prioritize workload to meet or exceed deadlines.
- Individual and team work ethic.
- Positive attitude, self-motivated, high level of engagement.
- Ability to understand and follow safety procedures.
- Champions company values including team engagement.
Education and Experience:
- Degree requirement: Bachelor's Degree with 2+ years of experience or Master's Degree with no experience in Analytical Chemistry, Chemistry, Biochemistry or closely related field
- Experience in working with UPLC and LC-MS systems.
