Site: The Brigham and Women's Hospital, Inc.

Job Summary
This is a one-year, fixed-term position with an anticipated duration of 12 months.

Bioinformatician: Computational Omics and Predictive Modeling
Responsible for developing, implementing, adapting, and validating computational prediction models using large-scale multi-omic, clinical, and phenotypic data. The role develops reproducible analytical workflows, optimizes code for high-performance computing, addresses cross-cohort differences in data processing and feature availability, and evaluates model performance in independent datasets across clinically relevant prediction horizons. Works collaboratively with investigators and external partners to ensure rigorous, reproducible, and interpretable model validation.

Essential Functions (Key Roles & Responsibilities)
• Independently conduct and support analysis of complex biological and multi-omic data using bioinformatics tools and software.
• Perform data processing, quality control, and database maintenance.
• Collaborate with research teams to understand their data analysis needs.
• Develop, implement, validate, and maintain reproducible data analysis pipelines
• Conduct advanced statistical and bioinformatic analyses and data visualization
• Lead or substantially contribute to interpretation and presentation of analytical results
• Working under very general supervision, the Bioinformatics Analyst will have demonstrated independent design and innovation in one or more of the following areas of specialization: algorithm development, data analysis, quality assurance/testing, pipeline software/computing development, user interface design & report development, web-based application development, or report development.
• Develop and validate multi-omic risk prediction models in a series of large cohorts.
• Design and evaluate statistical and machine-learning approaches for high-dimensional biological and clinical data
• Independently troubleshoot computational, analytical, and data-quality issues.
• Document methods, code, assumptions, and analytic decisions to ensure reproducibility and auditability
• Optimize workflows for large-scale and high-performance computing environments
• Conduct data analysis to uncover trends, patterns, and anomalies.
• Collaborate effectively with cross-functional teams.
• Support research security and compliance oversight by collaborating with the Institutional Review Board and other research governing bodies.
• Adhere to rigorous principles of reproducible research and data documentation.
• Substantially contribute to manuscripts, abstracts, reports, presentations, and grant-related analyses (e.g., scientific literature, reports, journal publications and presentations).
• Performs other duties as assigned
• Complies with all policies and standards

Qualifications

Education

Bachelor's Degree Computational Biology or Related Field of Study required

Master's Degree Related Field of Study preferred

Experience

Computational Sciences Experience: 0-1 year.

Computational Sciences Experience: 3+ years preferred

Knowledge, Skills and Abilities

• Demonstrated experience in infrastructure, programming languages, and computational sciences.
• Demonstrated ability working with open-source bioinformatics software.
• Possess strong analytical skills, including critical thinking, data modeling, problem solving, and troubleshooting.
• Strong organizational and interpersonal skills.
• Ability to effectively communicate, both orally and in writing, to all levels of staff.
• Excellent time management skills.

Additional Job Details (if applicable)

Remote Type

Hybrid

Work Location

1620 Tremont Street

Scheduled Weekly Hours

40

Employee Type

Regular

Work Shift

Day (United States of America)

Pay Range
$75,275.20 - $109,553.60/Annual

Grade
6

At Mass General Brigham, we believe in recognizing and rewarding the unique value each team member brings to our organization. Our approach to determining base pay is comprehensive, and any offer extended will take into account your skills, relevant experience if applicable, education, certifications and other essential factors. The base pay information provided offers an estimate based on the minimum job qualifications; however, it does not encompass all elements contributing to your total compensation package. In addition to competitive base pay, we offer comprehensive benefits, career advancement opportunities, differentials, premiums and bonuses as applicable and recognition programs designed to celebrate your contributions and support your professional growth. We invite you to apply, and our Talent Acquisition team will provide an overview of your potential compensation and benefits package.

Mass General Brigham Competency Framework

At Mass General Brigham, our competency framework defines what effective leadership "looks like" by specifying which behaviors are most critical for successful performance at each job level. The framework is comprised of ten competencies (half People-Focused, half Performance-Focused) and are defined by observable and measurable skills and behaviors that contribute to workplace effectiveness and career success. These competencies are used to evaluate performance, make hiring decisions, identify development needs, mobilize employees across our system, and establish a strong talent pipeline.