Mount Sinai Hospital

Associate Scientist - Computational Genomics & Large-Scale Molecular Data Analysis (Dr Sealfon's Lab) - Neurology

Mount Sinai Hospital$95K — $115K *
Pharmaceuticals & Biotech
Less than 5 years of experience
Job Overview by Ladders

Qualifications

  • Ph.D. in Biological Science or relevant field; Computational Biology or Statistics strongly preferred
  • Minimum of three years of relevant experience
  • Expertise in bulk and single-cell RNA-seq and epigenomic data analysis
  • Proficiency in R, particularly with single-cell analysis
  • Experience with large-scale genomic datasets and computing environments
  • Strong statistical background with data visualization skills
  • Experience with DNA methylation and long-read RNA sequencing data
  • Demonstrated use of machine learning or AI in genomics
  • Familiarity with cloud workflows and reproducible pipeline development
  • Proven record of publications in peer-reviewed journals

Responsibilities

  • Lead analysis of single-cell RNA-seq and multiome datasets
  • Perform integrative analysis of bulk RNA-seq, ATAC-seq, and DNA methylation data
  • Develop processing pipelines for single-cell multiomic technologies
  • Apply statistical modeling and machine learning to identify cellular states
  • Design and implement integrative multi-omic analyses
  • Present findings internally and contribute to publications
  • Stay updated on single-cell and AI-driven genomic methodologies
  • Perform related duties as needed.

Benefits

  • Collaborative research environment
  • Opportunities for publication and grant contributions
  • Exposure to cutting-edge technologies
  • Professional development in emerging genomic methodologies
  • Flexible workplace dynamics
Full Job Description
Job Description

We are seeking a highly motivated Associate Scientist to lead and support the analysis of large-scale molecular datasets in a dynamic, collaborative research environment. This role focuses on cutting-edge functional genomics, with an emphasis on single-cell and multi-omic technologies.

The Associate Scientist will drive computational analysis of high-dimensional datasets, partnering closely with a well-integrated computational-experimental team to generate biological insights from complex genomic data. The ideal candidate has deep expertise in single-cell transcriptomics and epigenomics, experience handling large-scale datasets, and strong quantitative and programming skills. Experience in machine learning and AI approaches is highly desirable.

Responsibilities

  • Lead analysis of single-cell RNA-seq and multiome datasets (joint RNA/ATAC profiling)
  • Perform integrative analysis across modalities, including bulk RNA-seq, ATAC-seq, and DNA methylation datasets
  • Develop processing pipelines for novel single cell multiomic technologies
  • Apply statistical modeling and machine learning methods to identify cellular states, regulatory programs, and epigenetic signatures
  • Design and implement integrative multi-omic analyses across cohorts and experimental systems
  • Present findings internally and contribute to publications and grant applications
  • Stay current with emerging single-cell and AI-driven genomic analysis methodologies
  • Performs other related duties.


Qualifications

  • Ph.D. in Biological Science or related field; PhD in Computational Biology, Bioinformatics, Genomics, Statistics, Computer Science, or related field highly preferred
  • Three years' experience
  • Strong experience analyzing bulk and single-cell RNA-seq and epigenomic data
  • Proficiency in R, including common single-cell analysis frameworks
  • Experience working with large-scale genomic datasets and high-performance computing environments
  • Strong statistical background and data visualization skills
  • Experience analyzing DNA methylation data (e.g., array-based or sequencing-based approaches)
  • Experience analyzing long-read RNA sequencing datasets
  • Demonstrated use of machine learning/AI methods for genomic data integration or prediction
  • Familiarity with cloud-based workflows and reproducible pipeline development
  • Track record of publications in peer-reviewed journals


About Mount Sinai Hospital

Mount Sinai Hospital is a hospital network based in New York City. It was founded in 1852 and is one of the oldest and largest teaching hospitals in the United States. The hospital has been ranked among the top hospitals in the country by U.S. News & World Report and is known for its excellence in patient care, research, and education. Mount Sinai Hospital is affiliated with the Icahn School of Medicine at Mount Sinai and has a staff of over 7,000 physicians, nurses, and other healthcare professionals.
Learn more about Mount Sinai Hospital
Size
42,000 employees
Industry
Founded
1997

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