Columbia University

Associate Research Scientist

Columbia University$70K — $95K *
Pharmaceuticals & Biotech
Less than 5 years of experience
Job Overview by Ladders

Qualifications

  • Doctoral degree in relevant field (PhD, MD, DVM, or equivalent)
  • Postdoctoral research training with preclinical experience
  • Hands-on experience with small animal imaging techniques
  • Experience administering radioisotope-labeled compounds
  • Strong quantitative imaging analysis skills
  • Proven track record of scientific publication

Responsibilities

  • Design and conduct in vitro studies on radiopharmaceuticals
  • Translate in vitro findings to small animal studies
  • Administer radioisotope-labeled tracers to small animals
  • Integrate various imaging data with biological endpoints
  • Analyze research data for publication and funding applications
  • Collaborate with scientists and clinicians on research projects
  • Ensure compliance with safety and IACUC protocols

Benefits

  • Opportunity to work in a multidisciplinary research environment
  • Access to mentorship for research development
  • Participation in innovative, relevant projects
  • Collaboration with leading scientists and core facilities
  • Institutional support for research compliance and professional development
Full Job Description
Description

The Department of Radiology at the College of Physicians and Surgeons of Columbia University Medical Center invites applications for an Associate Research Scientist.

The successful candidate will join a multidisciplinary research environment integrating radiochemistry, molecular imaging, and translational biomedical research. We seek candidates with strong technical expertise in preclinical molecular imaging and demonstrated potential to develop an independent, extramurally funded research program. Our team is highly collaborative and provides research mentoring as well as the opportunity to participate in a wide spectrum of highly relevant and innovative projects.

Specific duties include:

  1. Design and conduct in vitro studies to characterize radiopharmaceutical binding, specificity, internalization, stability, metabolism, and radiochemical performance using relevant cell-based and biochemical assays, including molecular biology and genetic modification.
  2. Translate in vitro findings to in vivo validation studies in small animal models, evaluating tracer biodistribution, pharmacokinetics, and therapeutic response.
  3. Perform radioisotope-labeled tracer administration in small animals (e.g., intravenous, intraperitoneal), with subsequent dissection, tissue analysis including microscopy and cell preparation for secondary culture or fluoroscopy analysis.
  4. Integrate PET and PET/CT, SPECT and optical imaging data with biological, molecular, and histopathologic endpoints to support translational research objectives.
  5. Perform independent analysis of research data with preparation for presentation, publication and submission of applications for independent funding; keep the appropriate research documentation.
  6. Collaborate with basic scientists, imaging physicists, clinicians, and core facilities to advance multi-investigator research projects.
  7. Perform all work in accordance with institutional radiation, biological, recombinant nucleic acid and chemical safety requirements and IACUC-approved protocols.
  8. Participate in laboratory safety, animal research oversight, and imaging core governance as appropriate.
  9. Uphold institutional standards for research compliance, professionalism, and collaboration.


Qualifications

Preferred Experience

  1. Successful application for competitive extramural grant applications (e.g., NIH K- and R-series, foundation funding) to support research independence.
  2. Participate in the development of shared imaging datasets and institutional research resources.
  3. Contribute to formal and informal educational activities within the department, graduate programs, or training grants.


Required Qualifications

  1. Doctoral degree (PhD, MD, DVM, or equivalent) in molecular imaging, nuclear medicine, radiology, biomedical sciences, pharmacology, biomedical engineering, or a related field.
  2. Postdoctoral or equivalent research training with demonstrated expertise in preclinical small animal studies and in vitro experiments.
  3. Hands-on experience with small animal PET or PET/CT, SPECT and optical imaging.
  4. Experience administering radioisotope-labeled compounds in mice.
  5. Strong background in quantitative imaging analysis and interpretation.
  6. Demonstrated ability to publish scientific research.


Preferred Qualifications

  1. Experience in radiopharmaceutical development or tracer evaluation.
  2. Familiarity with dynamic PET/SPECT/optical imaging and kinetic modeling.
  3. Evidence of prior or pending extramural funding (e.g., fellowship, career development award).
  4. Experience mentoring students or trainees.

About Columbia University

Columbia University is a private Ivy League research university in New York City. Established in 1754 as King's College on the grounds of Trinity Church in Manhattan, Columbia is the oldest institution of higher education in New York and the fifth-oldest institution of higher learning in the United States. It is one of nine colonial colleges founded prior to the Declaration of Independence, seven of which belong to the Ivy League. Columbia is ranked among the top universities in the world by major education publications. Columbia was established by royal charter under George II of Great Britain. It was renamed Columbia College in 1784 following the American Revolution, and in 1787 was placed under a private board of trustees headed by former students Alexander Hamilton and John Jay. In 1896, the campus was moved to its current location in Morningside Heights and renamed Columbia University. Columbia scientists and scholars have played a pivotal role in scientific breakthroughs including brain-computer interface; the laser and maser; nuclear magnetic resonance; the first nuclear pile; the first nuclear fission reaction in the Americas; the first evidence for plate tectonics and continental drift; and much of the initial research and planning for the Manhattan Project during World War II. Columbia is organized into twenty schools, including four undergraduate schools and 16 graduate schools. The university's research efforts include the Lamont–Doherty Earth Observatory, the Goddard Institute for Space Studies, and accelerator laboratories with Big Tech firms such as Amazon and IBM. Columbia is a founding member of the Association of American Universities and was the first school in the United States to grant the MD degree. The university also annually administers the Pulitzer Prize. With over 14.5 million volumes, Columbia University Library is the third-largest private research library in the United States.
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