Merck & Co, Inc

Associate Principal Scientist, Toxicology/Study Director

Merck & Co, Inc$142K — $224K *
Pharmaceuticals & Biotech
8 - 10 years of experience
Job Overview by Ladders

Qualifications

  • Master's degree in toxicology, pharmacology, or related field
  • Minimum 8 years of relevant experience
  • At least 5 years as a Study Director in pharma, biotech, or a CRO
  • Experience with GLP and non-GLP studies across varied models
  • Strong understanding of Good Laboratory Practices (US FDA 21 CFR Part 58)
  • Excellent communication skills, both verbal and written
  • Ability to influence and collaborate in a team environment

Responsibilities

  • Serve as Study Director for general toxicology studies
  • Critically analyze and interpret toxicology data for reports
  • Ensure adherence to regulatory standards and guidelines
  • Proactively identify risks and execute studies on time
  • Develop and maintain collaborative relationships across teams
  • Deliver quality results with accountability and agility
  • Lead or participate in method development and scientific projects

Benefits

  • Comprehensive medical, dental, and vision insurance
  • 401(k) retirement plan with contributions
  • Paid holidays, vacation, and sick leave
  • Annual bonus and long-term incentives eligibility
Full Job Description

Job Description

Job Description:

The Nonclinical Drug Safety department is seeking amotivated and talentedtoxicologistto conduct and/or monitor toxicity studies (GLP and non-GLP) as a Study Director or Study Monitor.  Toxicologists at our Company are integral members and leaders of collaborative cross functional scientific teams, addressing challenges from early discovery to late development. Our toxicologists provide scientific leadership in the design and overall conduct of in vivo studies and integrate the findings from all contributing scientists into reports that characterize the safety profile of drug candidates. 

Key Responsibilities

  • Serve as the single point of control (Study Director) on assigned acute through chronic general toxicology studies across allmodalities.  Interactwith technical, veterinary, and scientific staff to ensure that the study is in compliance withthe protocol, amendments, Standard Operating Procedures, regulations, safety guidelines, and company policies and procedures.

  • Critically analyze and interpret data. Integrate data from other areas (e.g., clinical pathology, pathology,toxicokinetics) in written reports used for regulatorysubmissions, andcommunicate results within established timelines.

  • Ensure regulatory rigor, proactive risk identification, and timely study execution.

  • Demonstrate enterprise mindset and strategic thinking, proactively identifying opportunities, anticipating challenges, and contributing to solutions aligned withNonclinical Drug Safetyorganizational priorities.

  • Build strongcollaborative relationships and influences without authority, contributing to an inclusive team environment.

  • Deliver high-quality results with accountability and agility, translating objectives into action while continuously improving,embracing change, and demonstrating leadership.

  • As needed, lead and/or participate in method development, inter-group initiatives, and various related scientific projects.

Education

  • Master’s degreewith training in toxicology, pharmacology, or related scientific discipline.

Requirements

  • Minimum of8years of relevant experience.

  • Minimum of 5 yearsas a Study Director in pharma, biotech, or at a CRO.

  • General toxicologyGLPStudy Directorexperience with varied models, routes of administration, and study designs.

  • Demonstrated understanding of Good Laboratory Practices (US FDA 21 CFR Part 58)

  • Strong interest in collaborating with diverse cross-functional teams and communicating openly and often with colleagues. 

  • Strong listeningand leadership skills

  • Ability to communicate clearly using verbal and written formats, including presentations

Preferred

  • GLP Study Director experience with varied modalities (e.g. biologics and small molecule therapeutics)

  • Familiarity with outsourced study monitoring

  • Familiarity with ICH safety guidelines

Required Skills:

Animal Studies, Effective Written Communication, Evaluate Information, Good Laboratory Practices (GLPs), Oral Communications, Proactive Thinking, Study Directing, Study Monitoring, Teamwork, Toxicology

Preferred Skills:

Current Employees apply

Current Contingent Workers apply

US and Puerto Rico Residents Only:

The salary range for this role is

$142,400.00 - $224,100.00

This is the lowest to highest salary we in good faith believe we would pay for this role at the time of this posting. An employee’s position within the salary range will be based on several factors including, but not limited to relevant education, qualifications, certifications, experience, skills, geographic location, government requirements, and business or organizational needs.

The successful candidate will be eligible for annual bonus and long-term incentive, if applicable.

We offer a comprehensive package of benefits.  Available benefits include medical, dental, vision healthcare and other insurance benefits (for employee and family), retirement benefits, including 401(k), paid holidays, vacation, and compassionate and sick days. More information about benefits is available at .

You can apply for this role through (or via the Workday Jobs Hub if you are a current employee). The application deadline for this position is stated on this posting.

San Francisco Residents Only: We will consider qualified applicants with arrest and conviction records for employment in compliance with the San Francisco Fair Chance Ordinance

Los Angeles Residents Only: We will consider for employment all qualified applicants, including those with criminal histories, in a manner consistent with the requirements of applicable state and local laws, including the City of Los Angeles’ Fair Chance Initiative for Hiring Ordinance

Search Firm Representatives Please Read Carefully 
Merck & Co., Inc., Rahway, NJ, USA, also known as Merck Sharp & Dohme LLC, Rahway, NJ, USA, does not accept unsolicited assistance from search firms for employment opportunities. All CVs / resumes submitted by search firms to any employee at our company without a valid written search agreement in place for this position will be deemed the sole property of our company.  No fee will be paid in the event a candidate is hired by our company as a result of an agency referral where no pre-existing agreement is in place. Where agency agreements are in place, introductions are position specific. Please, no phone calls or emails. 

Employee Status:

Regular

Relocation:

Domestic

VISA Sponsorship:

No

Travel Requirements:

No Travel Required

Flexible Work Arrangements:

Not Applicable

Shift:

Not Indicated

Valid Driving License:

No

Hazardous Material(s):

N/A

Job Posting End Date:

09/30/2026

*A job posting is effective until 11:59:59PM on the day BEFOREthe listed job posting end date. Please ensure you apply to a job posting no later than the day BEFORE the job posting end date.

About Merck & Co, Inc

Schering-Plough Corporation is a major U.S.-based manufacturer of pharmaceuticals. It operates in three segments: Prescription Pharmaceuticals, Animal Health, and Consumer Health Care. Schering-Plough develops products targeting on allergy, cancer, hepatitis, cardiovascular, central nervous system, respiratory system, and more.  It was founded in 1851 by Ernst Christian Friedrich Schering as Schering AG in Germany. Schering-Plough manufactured several pharmaceutical drugs, the most well-known of which were the allergy drugs Claritin and Clarinex, an anti-cholesterol drug Vytorin, and a brain tumor drug Temodar. It also developed drugs targeting on central nervous system and the respiratory system. Schering Plough also owned and operated the major foot care brand name Dr. Scholl's and the skin care line Coppertone. These also became a part of the new company. Schering-Plough was a full member of the European Federation of Pharmaceutical Industries and Associations (EFPIA), a membership which is also maintained by the new Merck.

Merck & Co, Inc Careers

Join the visionary team at Merck & Co, Inc, a global leader in healthcare dedicated to advancing the world of medicine. As part of our professional community, you'll find dynamic job opportunities that foster innovation and leadership across various fields. Merck & Co, Inc is not just a company; it's a place where you can make a difference.

Work You’ll Do

At Merck & Co, Inc, we are committed to improving global health through groundbreaking research and innovative healthcare solutions. Our team is at the forefront of developing new therapies and vaccines that significantly impact public health worldwide. By joining us, you will collaborate with some of the brightest minds in the industry, using your skills to contribute to projects that save and improve lives around the globe.

Explore Career Paths

Whether you're seeking an internship, a graduate opportunity, or a professional position, Merck & Co, Inc offers a range of career paths in environments that promote rapid professional growth and development. Explore job opportunities in research, digital transformation, manufacturing, and more, all while benefiting from a culture that supports diversity and inclusion.

Innovate and Lead

Merck & Co, Inc is an ideal environment for those who lead with curiosity and the drive to innovate. Our leadership is committed to fostering a culture where inventive thinking and collaboration are encouraged, making it a perfect place for professionals who seek to make an impact through their work.

Develop Your Skills

With Merck & Co, Inc, you are not just getting a job; you're gaining access to unparalleled career development opportunities. Enhance your skills through diverse training programs, workshops, and continuous learning courses designed to help you grow at every stage of your career.

Benefits and Culture

We understand that our employees are our greatest asset, which is why we offer competitive benefits designed to support the health and well-being of you and your family. From comprehensive health care coverage and retirement plans to flexible working conditions and wellness programs, our benefits package is designed to meet the diverse needs of our team members.

Join Our Team

Ready to advance your career at Merck & Co, Inc? Search open positions that match your skills and interests. We are continuously hiring and looking for passionate, creative, and solution-driven team players. Prepare your resume, sharpen your interview skills, and become part of a company that's dedicated to making a difference.

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Keep up to date with career tips, insider perspectives, and industry-leading insights you can put to use today—all from the people who work here. Engage with us through our careers blog and by participating in networking events and employment fairs. Subscribe to receive personalized job alerts and the latest news tailored to your preferences. Discover the exciting and rewarding opportunities that await at Merck & Co, Inc. Join us in our mission to improve health and wellness around the world.
Learn more about Merck & Co, Inc
Size
68,000 employees
Market Cap
$282.6 billion
Industry
Net Income
$7 billion
Founded
1668
5 Year Trend
+4.1%
Revenue
$47.9 billion
NASDAQ

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