Illumina Inc

Associate Principal, AI Engineering

Illumina Inc$187K — $281K *
Information Technology
11 - 15 years of experience
Job Overview by Ladders

Qualifications

  • 15+ years in software engineering with 5+ in architecture or senior leadership roles.
  • Expertise in full-stack development, including Python and Java ecosystems.
  • Proven experience with Generative AI solutions and prompt engineering.
  • Strong knowledge of major cloud platforms (GCP, Azure, or AWS) and multi-tenant systems.
  • Experience leading distributed teams of 15+ engineers across time zones.
  • Track record of delivering performance-driven enterprise systems.
  • Bachelor's or Master's degree in Computer Science, Engineering, or related field.

Responsibilities

  • Define architectures and standards for AI-enhanced applications across various platforms.
  • Collaborate on multi-year technology roadmaps aligning AI with business goals.
  • Evaluate new technologies and create actionable adoption plans.
  • Lead architectural reviews to ensure scalable and secure designs.
  • Design Generative AI solutions and responsible AI frameworks.
  • Establish MLOps practices for model deployment and monitoring.
  • Provide leadership and mentorship to a cross-functional engineering team.

Benefits

  • Access to genomics sequencing.
  • Family planning support.
  • Comprehensive health, dental, and vision coverage.
  • Retirement benefits.
  • Paid time off.
Full Job Description
Location

San Diego, CA

Summary

The Associate Principal, AI Engineer is a senior technical leader who partners with Principal Architects, business stakeholders, and engineering teams to translate enterprise strategy into scalable, AI-enabled technology solutions. This role blends deep hands-on technical depth across full-stack engineering, cloud platforms, and modern AI architectures with the leadership presence needed to influence cross-functional teams and shape long-range technology direction.

The successful candidate will architect production-grade systems that integrate Generative AI, agentic workflows, and RAG-based retrieval into core enterprise applications, while mentoring engineering teams and establishing the patterns, guardrails, and platforms that allow AI to scale responsibly across the organization.

Key Responsibilities

Architecture and Technical Strategy
  • Define reference architectures, design patterns, and platform standards for AI-enabled enterprise applications spanning web, mobile, and backend services.
  • Partner with the Principal Architect to develop multi-year technology roadmaps that align cloud, data, AI, and application strategy with business objectives.
  • Evaluate emerging technologies (foundation models, agentic frameworks, vector databases, MLOps tooling) and translate them into actionable adoption plans.
  • Lead architectural reviews, ensuring system designs meet requirements for scalability, security, performance, observability, and total cost of ownership.

AI and Generative AI Engineering
  • Architect Generative AI solutions including RAG systems, multi-agent workflows, conversational interfaces, and domain-specific fine-tuned models.
  • Design responsible AI frameworks covering prompt engineering standards, evaluation pipelines, model governance, and content safety controls.
  • Establish MLOps and LLMOps practices for model deployment, monitoring, drift detection, and continuous improvement.
  • Integrate LLM providers (OpenAI, Anthropic, Google) and orchestration frameworks (LangChain, LangGraph) into production systems with appropriate fallback and cost controls.

Cloud and Platform Engineering
  • Design cloud-native solutions on Google Cloud Platform, Azure, or AWS, leveraging managed AI services (Vertex AI, AlloyDB, Cloud Functions, equivalent services).
  • Architect CI/CD pipelines, infrastructure-as-code, and platform automation that accelerate engineering velocity without compromising reliability.
  • Define and enforce standards for containerization, microservices, API design, and event-driven architectures.

Leadership and Delivery
  • Provide technical leadership to engineering teams of 15 to 30 engineers, including UI developers, backend engineers, ML engineers, and platform specialists.
  • Mentor senior engineers and tech leads, growing the next generation of architects within the organization.
  • Partner with product, design, and business stakeholders to scope initiatives, manage trade-offs, and deliver measurable business outcomes.
  • Represent the architecture function in executive forums, vendor evaluations, and strategic planning sessions.

Required Qualifications
  • 15 or more years of progressive experience in software engineering, with at least 5 years in architecture or senior technical leadership roles.
  • Deep hands-on expertise across full-stack development, including Python and Java ecosystems (Spring Boot, Spring Cloud, microservices).
  • Proven experience architecting and deploying Generative AI solutions in production, including RAG systems, prompt engineering, and LLM integration.
  • Strong command of at least one major cloud platform (GCP, Azure, or AWS), with demonstrated experience designing scalable, multi-tenant systems.
  • Experience leading distributed engineering teams of 15 or more across multiple time zones.
  • Track record of delivering enterprise-grade systems that serve large user bases with measurable performance and revenue outcomes.
  • Bachelor's or Master's degree in Computer Science, Engineering, or a related discipline.

Preferred Qualifications
  • Experience with agentic AI frameworks (LangChain, LangGraph, AutoGen, CrewAI) and multi-agent system design.
  • Familiarity with Voice AI and conversational AI platforms, including ASR, TTS, and dialog management.
  • Background in commerce platforms (Bloomreach, Salesforce Commerce Cloud, Adobe Experience Cloud) or industrial and B2B e-commerce.
  • Exposure to data platforms (BigQuery, Snowflake, Databricks) and modern data architectures (lakehouse, streaming, vector stores).
  • Industry certifications such as TOGAF, GCP Professional Cloud Architect, Azure Solutions Architect Expert, or AWS Solutions Architect Professional.
  • Active engagement with the technology community through conference talks, publications, patents, or industry awards.
  • Senior membership in IEEE, ACM, or equivalent professional organization.


Technical Skill Profile
  • AI and Machine Learning: Generative AI, LLMs (GPT-4, Claude, Gemini), LangChain, LangGraph, RAG architectures, vector search, prompt engineering, fine-tuning, MLOps, responsible AI, multi-agent systems, Voice AI, semantic search.
  • Programming and Frameworks: Python, Java SE, Spring Boot, Spring MVC, Spring JPA, Spring REST, Spring Cloud, Hibernate, REST and GraphQL API design.
  • Cloud and DevOps: GCP (Vertex AI, AlloyDB, Cloud Functions), Azure, Docker, Kubernetes, Bamboo or equivalent CI/CD tooling, Terraform, observability stacks.
  • Web and Mobile: Angular, React, Node.js, modern JavaScript frameworks, HTML5, responsive design, accessibility standards.
  • Data: Oracle, MySQL, SQL Server, AlloyDB, vector databases (Pinecone, Weaviate, pgvector), event streaming (Kafka, Pub/Sub).


Leadership Competencies
  • Strategic Thinking: Ability to see beyond immediate technical decisions and shape multi-year technology direction.
  • Influence Without Authority: Effectiveness in moving cross-functional initiatives forward through expertise, clarity, and trust.
  • Executive Communication: Comfort articulating complex technical concepts to non-technical executives and translating business priorities into engineering plans.
  • Builder's Mindset: Genuine enthusiasm for hands-on problem solving alongside architectural leadership.
  • Mentorship: Demonstrated history of growing senior engineers into architects and leaders.


#LI-ONSITE

The estimated base salary range for the Associate Principal, AI Engineering role based in the United States of America is: $187,400 - $281,000. Should the level or location of the role change during the hiring process, the applicable base pay range may be updated accordingly. The range reflects long-term growth in the role; therefore, most candidates are hired between the minimum and middle of the range. Placement depends on experience, skills, location, and internal equity. Additionally, all employees are eligible for one of our variable cash programs (bonus or commission) and eligible roles may receive equity as part of the compensation package. We offer a wide range of benefits as innovative as our work, including access to genomics sequencing, family planning, health/dental/vision, retirement benefits, and paid time off.

About Illumina Inc

Illumina, Inc. is an American company incorporated in April 1998 that develops, manufactures and markets integrated systems for the analysis of genetic variation and biological function. The company provides a line of products and services that serves the sequencing, genotyping and gene expression markets. Its headquarters are located in San Diego, California.
Learn more about Illumina Inc
Size
9,800 employees
Market Cap
$30.3 billion
Industry
Net Income
$656 million
Founded
1998
5 Year Trend
+13.5%
Revenue
$3.2 billion
NASDAQ

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