Madrigal Pharmaceuticals is seeking an Associate Director, Study Toxicologist to support nonclinical development programs for metabolic dysfunction-associated steatohepatitis (MASH). This role focuses on the execution and scientific oversight of outsourced nonclinical studies supporting regulatory-stage development programs, partnering closely with Nonclinical Development program leads to ensure studies support regulatory submissions and clinical development. The successful candidate will support studies across toxicology, pharmacokinetics (PK), ADME, and bioanalytical disciplines, working with contract research organizations (CROs) and internal teams to deliver high-quality data aligned with program timelines. The role will support a range of nonclinical studies, including IND-enabling and later-stage safety studies, as programs progress through development. This role is part of the Nonclinical Development team within Research, supporting Madrigal's growing MASH portfolio and providing opportunities over time to contribute more broadly to nonclinical development strategy. Key Responsibilities Study Design & Oversight • Support the design and execution of nonclinical studies, including toxicology, PK, ADME, and bioanalytical studies. • Provide scientific oversight of outsourced studies, including protocol input, study monitoring, data review, and final report review. CRO & Study Management • Coordinate study placement and management at CROs, including vendor interaction, study startup, and timeline tracking. • Monitor study conduct at external vendors to ensure quality and alignment with program timelines and objectives. Data Review & Collaboration • Review and interpret study data and reports for accuracy, completeness, and scientific rigor. • Partner closely with Nonclinical Development program leads and cross-functional teams to support integrated development plans and contribute scientific input to nonclinical development strategy as appropriate. • Maintain clear communication with internal stakeholders and external partners throughout study execution. Qualifications Required • PhD (or equivalent) in Toxicology, Pharmacology, DMPK, or a related scientific discipline. • Relevant pharmaceutical or biotechnology industry experience supporting nonclinical development programs and 10+ years of relevant experience. • Experience managing outsourced nonclinical studies with CROs, including protocol and report review. • Strong attention to detail and ability to manage multiple studies simultaneously. • Excellent written and verbal communication skills. Preferred • Experience with small molecule and/or siRNA programs. • Experience supporting late-stage nonclinical studies, including reproductive and developmental toxicology (DART) and carcinogenicity studies. Madrigal's Total Rewards strategy is based on a biotech industry peer group comparator and is inclusive of base pay, bonus and equity. Our equity offers meaningful opportunity allowing our employees to share in the success they help create. By aligning individual and company performance, we empower employees to think like owners, giving them a stake in the organization. All employees receive equity, which we believe reinforces our ownership culture. Base salary is determined by several factors including the candidate's qualifications, skills, education, experience, business needs and market demands. As of the date of this posting, a good faith estimate of the current pay scale for this position, applicable to all candidates, is $178,000 - $218,000 per year. We comply with all applicable minimum wage laws. All full-time employees receive equity, which reinforces our ownership culture and offers meaningful opportunity for our employees to share in the success they help create. By aligning individual and company performance, we empower employees to think like owners, giving them a stake in the organization. Full-time employees are also eligible for comprehensive benefits, including flexible paid time off, medical, dental, vision and life/disability insurance, and 401(k) offerings (i.e., traditional, Roth, and employer match) in accordance with applicable plans. We also offer additional voluntary benefits like supplemental life insurance, legal services, and other offerings. In addition, we offer mental health benefits through our Employee Assistance Program for employees and their family. The company also provides other benefits in accordance with applicable federal, state, and local laws.