PhD in Pharmacology, Bone Biology, Physiology, Pharmaceutical Sciences, or related field with 4+ years of biopharmaceutical industry experience, or MS with 6+ years focusing on preclinical pharmacology and drug discovery.
Proven track record of supporting or leading pharmacology strategies across multiple biologic programs in a fast-paced biotech environment.
Deep experience managing external research workflows and CRO partnerships without reliance on an internal vivarium.
Demonstrated proficiency in selecting and executing statistical tests for in vivo pharmacology, biomarker evaluation, and PK/PD analysis.
History of authoring and defending pharmacology sections in regulatory filings (IND/CTA).
Advanced proficiency with scientific analysis and visualization tools (e.g., GraphPad Prism, Spotfire, Phoenix WinNonLin) and modern ELN/LIMS systems.
Exceptional communication skills to summarize complex multi-program data for stakeholders.
Responsibilities
Lead day-to-day operations, scheduling, sample management, and tracking of in vivo studies with CROs.
Formulate and execute integrated preclinical pharmacology strategies for multiple programs, establishing drug exposure, target engagement, and efficacy models.
Author and review high-quality study protocols, reports, and regulatory components.
Drive the evaluation and implementation of novel disease models and biomarkers to elucidate mechanism-of-action.
Analyze complex biological and PK/PD datasets to test scientific hypotheses and provide actionable recommendations to leadership.
Collaborate with Protein Engineering, Translational Medicine, and Toxicology teams on candidate profiling and clinical translation plans.
Present comprehensive data packages and risk-mitigation plans to internal leadership.
Benefits
Flexible work hours and the potential for remote work.
Opportunities for professional development and continued education.
Collaborative team environment with cross-functional partnership.
Cutting-edge projects in the field of bone health and biologics.
Full Job Description
Job Description
POSITION SUMMARY:
Associate Director of Pharmacology. The Associate Director will play a key role in driving and executing preclinical pharmacology studies across our growing pipeline of next-generation bone health biologics. Working across multiple development programs, you will support candidate evaluation and generate critical data for candidate selection and IND-enabling studies. In this individual contributor role, you will bridge strategic oversight with active operational management to ensure studies are designed, executed, tracked, and analyzed seamlessly to advance candidates toward key milestones.
Responsibilities
Lead the day-to-day operations, scheduling, sample management, and rigorous tracking of in vivo studies with external contract research organizations (CROs).
Formulate and execute integrated preclinical pharmacology strategies across multiple development programs, establishing clear drug exposure, target engagement, and efficacy models.
Author and review high-quality study protocols, study reports, and pharmacology components of regulatory packages (IND/CTA submissions and Investigator's Brochures).
Drive the evaluation, validation, and implementation of novel disease models and translational biomarkers to elucidate mechanism-of-action across target candidates.
Analyze and interpret complex biological and PK/PD datasets to pressure-test scientific hypotheses and deliver actionable "go/no-go" recommendations to leadership.
Partner closely with Protein Engineering, Translational Medicine, and Toxicology teams to align on biological candidate profiling, dose selection rationale, and clinical translation plans.
Present comprehensive data packages, program updates, and strategic risk-mitigation plans to internal leadership.
Experience & Qualifications
PhD in Pharmacology, Bone Biology, Physiology, Pharmaceutical Sciences, or a related field with 4+ years of biopharmaceutical industry experience (or MS with 6+ years of experience) focusing on preclinical pharmacology and drug discovery.
Proven track record of supporting or leading pharmacology strategies across multiple biologic programs simultaneously within a fast-paced biotech environment.
Deep experience in managing externalized research workflows, operational study tracking, and CRO partnerships without reliance on an internal vivarium.
Demonstrated proficiency in selecting and executing appropriate statistical tests for in vivo pharmacology, biomarker evaluation, and PK/PD data analysis.
Demonstrated history of authoring and defending pharmacology sections in regulatory filings (IND/CTA).
Advanced proficiency with scientific analysis and visualization tools (e.g., GraphPad Prism, Spotfire, Phoenix WinNonLin) and modern ELN/LIMS systems.
Exceptional communication skills with the ability to summarize complex multi-program data into clear, strategic narratives for cross-functional stakeholders.
