Career CategoryScientific
Job DescriptionAssociate Director - Computational Biology (Cardiovascular, Metabolic, Obesity and Related)What you will doLet's do this. Let's change the world. The Computational Biology group in the Center for Technology and Innovation (CfTI) within the Precision Medicine organization at Amgen is seeking a highly motivated Computational Biologist with expertise in analyzing clinical biomarker data, including but not limited to metabolomics, genomics, transcriptomics, proteomics, spatial-omics, flow cytometry, immunoassays, and other biomarker assays. In this vital role, you will contribute to advancing Amgen's clinical programs and studies by integrating computational biology and bioinformatics techniques with biological and clinical data. The ideal candidate will have experience in matrixed environments, supporting therapeutic development by providing insights derived from clinical biomarker data. Support Amgen CVMet and OaR teams as a CompBio Therapeutic Area Lead and Global Biomarker Analysis Lead.
- Develop biomarker analysis plans to support precision medicine, evidence generation and reverse translation during clinical development of therapeutic molecules.
- Define and execute workflows for biomarker data analysis, integrating multiple omics, imaging and digital biomarkers, integrated with clinical metadata and outcomes
- Lead the analysis and interpretation of clinical biomarker data from various assay platforms, including metabolomics, imaging, flow cytometry, immunoassays, transcriptomics, proteomics, and spatial omics.
- Support the generation of evidence for target engagement evaluation, patient stratification, response prediction, indication selection, assay development, and diagnostic development.
- Work closely with clinical scientists and biomarker leads, to extract biological insights from high-dimensional datasets and integrate them into translational analytics, precision medicine plans and clinical development plans.
- Collaborate cross-functionally with early development teams, biostatistics, clinical pharmacology, precision medicine leads, clinical biomarker leads, and research teams to manage data integration, analysis, and presentation.
- Support Amgen internal and external presentations with fit-for-purpose analysis insights and messaging and support the development of publications
What we expect of youWe are all different, yet we all use our unique contributions to serve patients. The dynamic professional we seek is a leader with these qualifications.
Basic Qualifications:Doctorate degree [and relevant post-doc where applicable] and 4 years of scientific experience
OR
Master's degree and 7 years of scientific experience
OR
Bachelor's degree and 9 years of scientific experience
Preferred Qualifications:- PhD in Bioinformatics, Mathematics, Computer Science, Computational Biology or Data Science, with a minor or robust background in Biology
- A background in cardiovascular diseases, obesity and chronic weight management, and other metabolic diseases is highly preferred.
- Hands-on experience in statistical modeling, machine learning, and AI applied to clinical biomarker and clinical efficacy data
- A strong understanding and practical skills in statistics and their use in data analysis for clinical settings
- Proven expertise in analyzing multi-modal, multi-dimensional, and large-scale biological data.
- Prior experience working in a matrixed biotechnology or pharmaceutical setting. Proficiency in R and Python programming, with familiarity in various principles for data manipulation and visualization.
- Familiarity with agentic frameworks and the ability to build agents for day-to-day tasks that can be automated
- Strong understanding of platforms used in clinical biomarker research, including pathomics, cytomics, immunoassays, mass-spectrometry, other metabolomics platforms, next-generation sequencing (NGS), and proteomics
- Knowledge of inflammatory, cardiovascular and metabolic diseases and how computational biology can drive drug discovery and development in these areas
- Ability to translate biological and medical questions into analytical models providing actionable results
- Excellent written and oral communication skills with the ability to present complex data analyses in diverse settings, including cross-functional team meetings, external collaborations, and scientific publications.
- Strong project management skills and organizational awareness, self-motivation, independence, and leadership
What you can expect of usAs we work to develop treatments that take care of others, we also work to care for your professional and personal growth and well-being. From our competitive benefits to our collaborative culture, we'll support your journey every step of the way.
The expected annual salary range for this role in South San Francisco is posted. The expected salary range outside of South San Francisco is $182,465 - 246,865. Actual salary will vary based on several factors including but not limited to, relevant skills, experience, and qualifications.
In addition to the base salary, Amgen offers a Total Rewards Plan, based on eligibility, comprising of health and welfare plans for staff and eligible dependents, financial plans with opportunities to save towards retirement or other goals, work/life balance, and career development opportunities that may include:
- A comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions, group medical, dental and vision coverage, life and disability insurance, and flexible spending accounts
- A discretionary annual bonus program, or for field sales representatives, a sales-based incentive plan
- Stock-based long-term incentives
- Award-winning time-off plans
- Flexible work models where possible. Refer to the Work Location Type in the job posting to see if this applies.
Apply now and make a lasting impact with the Amgen team.careers.amgen.comIn any materials you submit, you may redact or remove age-identifying information such as age, date of birth, or dates of school attendance or graduation. You will not be penalized for redacting or removing this information.
Application deadlineAmgen does not have an application deadline for this position; we will continue accepting applications until we receive a sufficient number or select a candidate for the position.
SponsorshipSponsorship for this role is not guaranteed.
