ACADIA Pharmaceuticals

Associate Director, AI/ML Engineering

ACADIA Pharmaceuticals$172K — $215K *
Pharmaceuticals & Biotech
5 - 7 years of experience
Job Overview by Ladders

Qualifications

  • Master's or PhD in Machine Learning, Computer Science, or related field
  • 7+ years in AI/ML engineering, 3+ years with Generative and agentic AI systems
  • Expertise in multi-agent frameworks like LangGraph and AutoGen
  • Experience with MCP server creation and AI system integration
  • Strong background in Retrieval-Augmented Generation (RAG) pipeline development
  • Proficient in Python and machine learning libraries (e.g., PyTorch, TensorFlow)
  • Experience in ML Ops practices for model lifecycle management

Responsibilities

  • Design and deploy agentic AI workflows for complex business automation
  • Architect MCP servers to standardize enterprise tools and data for AI consumption
  • Connect multi-agent systems to ensure context-aware AI solutions
  • Collaborate with teams to establish data standards and quality thresholds for AI use cases
  • Implement planning and reasoning systems for reliable task execution
  • Evaluate AI system performance against benchmarks for accuracy and safety
  • Develop guardrail frameworks for compliance and trust in AI solutions

Benefits

  • Competitive base salary with discretionary bonuses
  • Medical, dental, and vision insurance
  • 401(k) Plan with company match
  • Employee Stock Purchase Plan with a purchase price lock-in
  • 15+ vacation days and paid holidays
  • Paid parental leave and tuition assistance
Full Job Description
Please note that this position is based in San Diego, CA, South San Francisco, CA, or Princeton, NJ. Acadia's hybrid model requires this role to work in our office three days per week on average.

Position Summary

The Associate Director, AI/ML Engineering serves as a hands-on technical leader driving the design, architecture, and delivery of Generative AI and agentic AI solutions across the enterprise. This role builds scalable multi-agent systems, connects AI solutions to enterprise data and tools, and ensures safe, reliable deployment through robust evaluation and guardrail frameworks. The position also applies strong machine learning and foundation model expertise to deliver high-impact use cases within a regulated biopharmaceutical environment.

Primary Responsibilities
  • Design, build, and deploy agentic AI workflows that automate and transform complex business processes, leveraging multi-agent orchestration frameworks (e.g., LangGraph, AutoGen, CrewAI, or equivalent).
  • Architect and implement MCP servers to expose enterprise tools, APIs, and data sources as standardized capabilities consumable by AI agents.
  • Connect multi-agent systems to enterprise databases, internal APIs, and MCP servers to enable grounded, context-aware, and action-oriented AI solutions.
  • Partner cross-functionally with internal teams to define data contracts, lineage standards, and quality thresholds required for AI/ML use cases.
  • Design and implement agentic memory systems (short-term, long-term, episodic) and planning/reasoning loops to support reliable autonomous task execution.
  • Evaluate agentic system performance across accuracy, reliability, latency, cost, and safety dimensions using structured benchmarks and red-teaming methodologies.
  • Build and maintain guardrail frameworks (input/output filtering, content moderation, policy enforcement, hallucination detection) to ensure the safety, compliance, and trustworthiness of GenAI and agentic solutions.
  • Develop retrieval-augmented generation (RAG) pipelines, including chunking strategies, embedding models, vector store selection, and retrieval optimization for enterprise knowledge bases.
  • Apply prompt engineering, few-shot learning, and fine-tuning techniques to adapt foundation models for domain-specific pharma use cases.
  • Design, develop, validate, and deploy traditional machine learning models (classification, regression, clustering, time-series, survival analysis) to address structured business problems.
  • Build and maintain end-to-end ML pipelines adhering to LLM Ops / ML Ops standards including model registry, evaluation benchmarks, prompt/version control, observability, and rollback procedures.
  • Experience in working with real-world data (RWD), claims data, EHR data, Clinical Study data, translational and biological data and the corresponding databases is a plus.
  • Other responsibilities as assigned.

Education/Experience/Skills
  • Master's or PhD in Machine Learning, Computer Science, Data Science, Information Systems, or a related quantitative discipline
  • Minimum of 7 years of experience in AI/ML engineering, including at least 3 years of hands-on experience with Generative AI and agentic AI systems
  • Expertise in multi-agent frameworks such as LangGraph, AutoGen, CrewAI, Semantic Kernel, or similar technologies
  • Experience building MCP servers and integrating AI systems with enterprise data sources, APIs, and tools
  • Strong experience in RAG pipeline development, embedding models, and vector database technologies
  • Proficiency in Python and machine learning frameworks such as PyTorch, TensorFlow, scikit-learn, and Hugging Face
  • Experience implementing ML Ops or LLM Ops practices, including model lifecycle management, evaluation, and deployment
  • Ability to travel domestically and internationally as required

Physical Requirements

This role involves regular standing, walking, sitting, and the use of hands for handling or operating equipment. The employee may also need to reach, climb, balance, stoop, kneel, crouch, and maintain visual, verbal, and auditory communication in a standard office environment and while working independently from remote locations. The employee must occasionally lift and/or move up to 20 pounds. This position requires the ability to travel independently overnight and/or work after hours as required by travel schedules or business needs.

#LI-HYBRID

#LI-CS1

In addition to a competitive base salary, this position is also eligible for discretionary bonus and equity awards based on factors such as individual and organizational performance. Actual amounts will vary depending on experience, performance, and location.

Salary Range

$172,000-$215,000 USD

What we offer US-based Employees:
  • Competitive base, bonus, new hire and ongoing equity packages
  • Medical, dental, and vision insurance
  • Employer-paid life, disability, business travel and EAP coverage
  • 401(k) Plan with a fully vested company match 1:1 up to 5%
  • Employee Stock Purchase Plan with a 2-year purchase price lock-in
  • 15+ vacation days
  • 13 -15 paid holidays, including office closure between December 24th and January 1st
  • 10 days of paid sick time
  • Paid parental leave benefit
  • Tuition assistance

About ACADIA Pharmaceuticals

ACADIA Pharmaceuticals is a biopharmaceutical company focused on the development and commercialization of innovative medicines to address unmet medical needs in central nervous system (CNS) disorders. The company's lead product, Nuplazid (pimavanserin), is the first and only FDA-approved treatment for hallucinations and delusions associated with Parkinson's disease psychosis. ACADIA's pipeline includes product candidates for the treatment of schizophrenia, dementia-related psychosis, and major depressive disorder. The company was founded in 1993 and is headquartered in San Diego, California.
Learn more about ACADIA Pharmaceuticals
Size
500 employees
Market Cap
$2.5 billion
Industry
Net Income
-$281.5 million
Founded
1993
5 Year Trend
+94.6%
Revenue
$441.7 million
NASDAQ

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