St. Jude Children's Research Hospital

Architect - Enterprise AI (Memphis, TN / Coppell TX) or Remote in USA

Enterprise Technology
8 - 10 years of experience
Job Overview by Ladders

Qualifications

  • Bachelor's degree in Computer Science, Information Systems, Engineering, or a related field.
  • 10+ years of experience in enterprise architecture, software engineering, or related technology disciplines.
  • Expertise in AI, Generative AI, and machine learning solution design and implementation.
  • Proven track record in developing architecture standards and technology governance practices.
  • Strong understanding of cloud platforms, application integration, and enterprise security.
  • Effective communication of technical concepts to diverse audiences.
  • 5+ years of experience in leadership or influencing architecture decisions.

Responsibilities

  • Define AI architecture standards and implementation patterns.
  • Collaborate with teams to evaluate AI use cases and provide architectural insights.
  • Design maintainable reusable architecture patterns for AI implementations.
  • Establish AI security, compliance, and governance guidelines.
  • Support AI development lifecycle practices through architecture reviews and standards.
  • Define AI evaluation and operational readiness architectures.
  • Develop reference implementations to accelerate AI capabilities into production.

Benefits

  • Low cost, low deductible Medical, Dental, and Vision insurance plans.
  • 401K Retirement Plan with a 7% Employer Contribution.
  • Exceptional Paid Time Off.
  • Maternity and Paternity Leave.
  • Infertility Treatment Program.
  • Adoption Assistance.
  • Education Assistance and Enterprise Learning opportunities.
Full Job Description
Job Description

The Enterprise AI Architect is responsible for defining and evolving ALSAC's enterprise architecture standards for Artificial Intelligence (AI), Agentic AI, and AI-enabled applications. This role partners with technology and business teams to ensure AI solutions align with enterprise architecture principles and are scalable, secure, reliable, and maintainable.

The Enterprise AI Architect provides architecture guidance, develops reusable patterns and standards, and helps teams successfully move AI solutions from concept through production implementation. This role collaborates across stakeholders to evaluate technologies, establish best practices, and ensure AI investments support ALSAC's long-term technology strategy.

Essential Job Functions
  • Define enterprise architecture standards, reference architectures, and implementation patterns for AI, Agentic AI, and AI-enabled solutions.
  • Partner with Enterprise Architecture, Engineering, Data, Security, and business teams to evaluate AI use cases, establish success criteria, and provide guidance on architectural tradeoffs, including model selection, agent design patterns, cost considerations, and responsible AI practices.
  • Design and maintain reusable architecture patterns for AI gateways, Model Context Protocol (MCP) integrations, agent orchestration, enterprise knowledge access, retrieval architectures, and AI platform services.
  • Establish architectural guidance for AI security, identity management, authorization, governance, compliance, and policy enforcement.
  • Support adoption of AI development lifecycle (AI-DLC) practices through architecture reviews, standards, reference implementations, and implementation guidance.
  • Define architectural approaches for AI evaluation, observability, monitoring, operational readiness, and cost management.
  • Develop reference implementations and proof-of-concept solutions that accelerate delivery and help teams scale AI capabilities into production environments.
  • Ensure AI and technology solutions align with enterprise architecture standards, strategic technology roadmaps, and long-term operational objectives.
  • Collaborate with stakeholders to gather, analyze, communicate, and validate requirements impacting ALSAC's enterprise technology environment.

Required Qualifications
  • Bachelor's degree in Computer Science, Information Systems, Engineering, or a related field.
  • 10+ years of experience in enterprise architecture, solution architecture, systems integration, software engineering, or related technology disciplines.
  • Experience designing and implementing AI, Generative AI, machine learning, or intelligent automation solutions.
  • Experience developing architecture standards, reference architectures, and technology governance practices.
  • Strong understanding of cloud platforms, application integration, enterprise security, and modern software architecture patterns.
  • Ability to communicate technical concepts effectively to both technical and non-technical stakeholders.
  • 5+ years of leadership, team lead, or architecture influence experience.

Preferred Qualifications
  • Experience with Azure AI Services, Azure OpenAI, Microsoft Copilot, or similar enterprise AI platforms.
  • Knowledge of large language models (LLMs), retrieval-augmented generation (RAG), agent frameworks, vector databases, and AI observability practices.
  • Experience with responsible AI, AI governance, security, and compliance frameworks.
  • Experience creating reusable frameworks, accelerators, and architecture guidance for enterprise technology teams.


ALSAC is committed to providing flexible work options. This role may be based in a hybrid schedule for candidates located near our Memphis, TN or Coppell, TX offices. For highly qualified candidates in other U.S. locations, remote work arrangements may be available.

Benefits & Perks
The following Benefits & Perks apply toFull-Time Roles Only
We're dedicated to ensuring children and their families have every opportunity to enjoy life's special moments. We're also committed to giving our staff excellent benefits so they can do the same.

  • Core Medical Coverage: (low cost low deductible Medical, Dental, and Vison Insurance plans)
  • 401K Retirement Plan with 7% Employer Contribution
  • Exceptional Paid Time Off
  • Maternity / Paternity Leave
  • Infertility Treatment Program
  • Adoption Assistance
  • Education Assistance
  • Enterprise Learning and Development
  • And more


About St. Jude Children's Research Hospital

St. Jude Children's Research Hospital is a pediatric treatment and research facility focused on children's catastrophic diseases, particularly leukemia and other cancers. The hospital was founded in 1962 by entertainer Danny Thomas and is located in Memphis, Tennessee. St. Jude is the first and only pediatric cancer center to be designated as a Comprehensive Cancer Center by the National Cancer Institute. The hospital has treated children from all 50 states and from around the world. St. Jude is known for its groundbreaking research and treatment of childhood cancer and other life-threatening diseases.
Learn more about St. Jude Children's Research Hospital
Size
4,500 employees
Industry
Founded
1962

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