La Jolla Institute for Allergy and Immunology (LJI, previously LIAI) is dedicated to understanding the intricacies and power of the immune system to that we may apply that knowledge to promote human health and prevent a wide range of diseases. Since its founding in 1988 as an independent, non-profit research organization, the Institute has made numerous advances leading towards its goal: Life Without Disease. The La Jolla Institute for Allergy & Immunology launched the Center for Infectious Disease in 2006, focusing research efforts on new and re-emerging infectious diseases such as West Nile virus and avian influenza, along with potential bioterrorist agents such as smallpox. The Center is led by vaccine expert Alessandro Sette, Ph.D. The development of vaccinations continues to be a major priority in research and clinical medicine. There are a large number of diseases that do not have vaccinations that are effective, as in the case of HIV and malaria. New and emerging infectious agents such as SARS and avian flu, as well as resurfacing dormant diseases, are frequently without effective treatment as well. Threats of bioterrorism are also bringing the attention of the medical research community back to diseases such as anthrax and smallpox. La Jolla Institutes research scientists are working to understand how we can better immunize ourselves against infection and how we can better combat infections once we have been exposed.