Senior Scientist, Translational ImmunologyLocation: South San Francisco, CA (On-site)
The PositionWe are seeking a Senior Scientist to join our team and drive projects enabling the translation, validation, and execution of preclinical biomarkers to the clinic.
Primary Responsibilities:- Identify and validate biomarkers relevant to the pharmacology of target clinical candidates.
- Lead context-of-use validation (in-house or through CLIA-certified laboratories or clinical CROs) of clinical biomarker assays suitable for use in recommended phase 2 dosing selection and/or regulatory submission.
- Write and amend internal SOPs and reports as necessary for GSP or GCLP purposes.
- Liaise with nonclinical pharmacology and discovery immunology teams to establish proof-of-concept/proof-of-mechanism biomarker strategies suitable for use in NHPs and FIH studies.
- Participate in all aspects of lab operation, training, and compliance including external audits where applicable.
- Other duties and responsibilities as assigned.
Requirements: - Bachelors degree with a minimum 10 years of experience or a Masters degree with a minimum of 6 years of experience (at least 2 years must be in biotech or industry setting) in Immunology or other relevant life sciences. Experience with regulatory T cells or Tr1 cells will be prioritized.
- Expertise in high-dimensional flow cytometry assays including but not limited to spectral flow cytometry and CyTOF.
- Experience leading phase appropriate clinical bioanalytical assay development and analyses including full validation and management of clinical bioanalytical labs/CROs.
- Experience developing lean and agile clinical biomarker budgets suitable for early phase POC and POM studies.
- Nice to have:
- Experience with nanomedicine
- Experience with IQOQ
- Familiarity with biomarker-centric platforms such as spatial profiling, multi-omics integration
- Excellent oral, written communication, and presentation skills.
- Demonstrated ability to effectively work in cross-functional teams, meet deadlines, and prioritize multiple projects is required.
- Comfortable working collaboratively in a small, fast-paced environment.
- Ability to quickly adjust to shifting project demands and priorities.
The expected annual salary range for this role is $150,000 - $170,000. Actual pay will be determined based on experience, qualifications, geographic location, business needs, and other job-related factors permitted by law.
