Repligen Corporation

Senior Scientist

Repligen Corporation$115K — $145K *
Pharmaceuticals & Biotech
5 - 7 years of experience
Job Overview by Ladders

Qualifications

  • MS or PhD in Biochemistry, Chemical Engineering, or related field
  • 5+ years of hands-on experience in downstream processing and protein purification
  • Experience with various biopharmaceutical modalities like vaccines and enzymes
  • Expertise in chromatography method development and high-throughput systems
  • Strong proficiency in Design of Experiments for process optimization
  • Working knowledge of analytical techniques for protein analysis
  • Broad understanding of separations, protein chemistry, and bioprocessing

Responsibilities

  • Design, develop, and optimize affinity chromatography purification processes
  • Execute high-throughput chromatographic screening using DOE methodologies
  • Analyze and interpret complex datasets for decision-making
  • Collaborate with internal teams to deliver integrated purification solutions
  • Contribute to development programs ensuring timely execution
  • Innovate to improve purification performance and scalability
  • Engage with external partners as a technical expert

Benefits

  • Paid time off
  • Health, dental, and vision coverage
  • Retirement benefits
  • Flexible spending accounts
  • Opportunity for variable cash programs like bonuses or commissions
  • Potential for equity participation in compensation package
Full Job Description
Lead the design and optimization of next-generation affinity purification technologies for a wide range of biopharmaceutical modalities. This role combines high-throughput experimentation, data-driven process development, and cross-functional collaboration to deliver innovative purification solutions that accelerate bioprocessing performance and enable partner success.

Key Responsibilities
  • Design, develop, and optimize affinity chromatography-based purification processes for diverse biopharmaceutical modalities
  • Execute high-throughput chromatographic screening and apply DOE methodologies to accelerate process development
  • Analyze, interpret, and communicate complex datasets to drive decision-making and support partner adoption of new technologies
  • Collaborate cross-functionally with internal teams (chemistry, analytics, commercial) to deliver integrated purification solutions
  • Contribute to multiple development programs, ensuring timely execution and high-quality scientific output
  • Innovate and propose novel approaches to improve purification performance, selectivity, and scalability
  • Engage with external biopharma partners as a technical expert and scientific collaborator


Qualifications
  • MS or PhD in Biochemistry, Chemical Engineering, Biochemical Engineering, or related field
  • Minimum of 5 years of hands-on experience in downstream processing and protein purification; including FPLC
  • Experience across multiple modalities (e.g., proteins, enzymes, vaccines, VLPs, gene therapy vectors)
  • Expertise in chromatography method development, including automated/high-throughput systems
  • Strong proficiency with Design of Experiments (DOE) for process optimization
  • Working knowledge of analytical techniques (e.g., purity/impurity analysis, potency, stability assays)
  • Broad scientific understanding spanning separations, protein chemistry, and bioprocessing
  • Strong communication skills with the ability to translate data into clear, actionable insights
  • Self-motivated, collaborative, and effective in a fast-paced, innovation-driven environment

The estimated salary range for this role, based in the United States of America is $115,000/yr. -$145,000/yr.

Compensation decisions are dependent on several factors including, but not limited to an individual's qualifications, location, internal equity, and alignment with market data. Additionally, employees are eligible to participate in one of our variable cash programs (bonus or commission) and eligible roles may receive equity as part of the compensation package. We offer a wide range of benefits such as paid time off, health/dental/vision, retirement benefits and flexible spending accounts. All compensation and benefits information will be confirmed in writing at the time of offer.

About Repligen Corporation

Repligen Corporation is a bioprocessing company headquartered in Waltham, Massachusetts that provides products and services to the biopharmaceutical industry. The company's products are used in the production of monoclonal antibodies, recombinant proteins, and vaccines. Repligen's product portfolio includes chromatography products, filtration products, and protein A ligands. The company also provides bioprocess services, including process development and optimization, analytical testing, and protein characterization. Repligen was founded in 1981 and has grown through a combination of organic growth and acquisitions.
Learn more about Repligen Corporation
Size
1,852 employees
Market Cap
$9.5 billion
Industry
Net Income
$59.9 million
5 Year Trend
+45%
Revenue
$366.2 million
NASDAQ

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