Job DescriptionRole Overview:Legend Biotech is a clinical stage biopharmaceutical company focused on the discovery and development of novel cell therapies for oncology, immunology and infectious disease indications. We are currently seeking talented and motivated individuals to join the group of Cell Biology and Immunology in the R&D Department located at Piscataway of New Jersey. The successful candidate should possess extensive knowledge and hands-on experience in oncology, cell biology and immunology, in particular TCR-T/CAR-T cell biology. The candidate will be able to contribute to the effort for developing T cell therapy platform, building and optimizing cell-based immunoassays to characterize and assess TCR-T/CAR-T cell functions. Experience with TCR-T/CAR-T cells is preferred. As major contributors of pipeline development, the candidates need to demonstrate the ability of planning, designing, executing complicated experiments and delivering scientific results in a cross-functional environment. This position also requires supervision and management skills.
Major Responsibilities: - Independently plan, design, execute experiments to assess the in-vitro functions of TCR-T/CAR-T cells
- Develop T cell therapy platform and optimize cell-based immunoassays, including ex-vivo antigen-specific T cell isolation and expansion. Multi-color flow cytometry, ELISA, ELISPOT, cytotoxic assays
- Deliver scientific results at internal and external meetings
- Supervise associate scientists for routine laboratory work
- Help group leader for general laboratory management
- Serve as the major contributors for pipeline development
QualificationsEducation: - PhD in cell biology/Immunology
Experience: - >3 years' post-graduate experience in human T-cell biology and immunology
- Extensive hands-on experience in TCR-T/CAR-T cell for cancer immunotherapy
- >1 years' supervisory experience
Key Capabilities, Knowledge, and Skills: - Extensive knowledge and hands-on experience in TCR-T/CAR-T field. Experience in immune-oncology preferred
- Expertise in cell biology and immune cell profiling. Extensive experience in multi-color flow-cytometry
- Hands-on experience and troubleshooting proficiency with immune cell isolation from peripheral blood and leukopak, expansion, and cell based immunoassays
- Experience with dendritic cell culture and DC-T cell cocluture for antigen-specific T cell
- Experience with lentivirus/retrovirus preparation, titration and T cell transduction
- Experience in CRISPR/CAS-9 for gene knock-out and knock-in
- Track record of scientific publications and accomplishments
- Demonstrated ability in presenting scientific results
- Excellent oral and written communication skills
- A team player who can work efficiently as an individual
